Zobrazeno 1 - 10
of 80
pro vyhledávání: '"Sean Harrison"'
Autor:
Teri-Louise North, Sean Harrison, Deborah C Bishop, Robyn E Wootton, Alice R Carter, Tom G Richardson, Rupert A Payne, Chris Salisbury, Laura D Howe
Publikováno v:
BMC Public Health, Vol 23, Iss 1, Pp 1-11 (2023)
Abstract Background Multimorbidity, typically defined as having two or more long-term health conditions, is associated with reduced wellbeing and life expectancy. Understanding the determinants of multimorbidity, including whether they are causal, ma
Externí odkaz:
https://doaj.org/article/995b2b9d434d4c2399d8ef82085605cd
Autor:
Ben Brumpton, Eleanor Sanderson, Karl Heilbron, Fernando Pires Hartwig, Sean Harrison, Gunnhild Åberge Vie, Yoonsu Cho, Laura D. Howe, Amanda Hughes, Dorret I. Boomsma, Alexandra Havdahl, John Hopper, Michael Neale, Michel G. Nivard, Nancy L. Pedersen, Chandra A. Reynolds, Elliot M. Tucker-Drob, Andrew Grotzinger, Laurence Howe, Tim Morris, Shuai Li, The Within-family Consortium, The 23andMe Research Team, Adam Auton, Frank Windmeijer, Wei-Min Chen, Johan Håkon Bjørngaard, Kristian Hveem, Cristen Willer, David M. Evans, Jaakko Kaprio, George Davey Smith, Bjørn Olav Åsvold, Gibran Hemani, Neil M. Davies
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
Family-based study designs have been applied to resolve confounding by population stratification, dynastic effects and assortative mating in genetic association analyses. Here, Brumpton et al. describe theory and simulations for overcoming such biase
Externí odkaz:
https://doaj.org/article/85accda5604c471488ab1aecb46cd352
Publikováno v:
PLoS Medicine, Vol 18, Iss 8, p e1003725 (2021)
BackgroundThe prevalence of obesity has increased in the United Kingdom, and reliably measuring the impact on quality of life and the total healthcare cost from obesity is key to informing the cost-effectiveness of interventions that target obesity,
Externí odkaz:
https://doaj.org/article/506409e247414196b7a7b8c31d0f49ef
Autor:
Lucy J Goudswaard, Sean Harrison, Daniel Van De Klee, Nishi Chaturvedi, Debbie A Lawlor, George Davey Smith, Alun D Hughes, Laura D Howe
Publikováno v:
PLoS ONE, Vol 16, Iss 6, p e0253196 (2021)
Greater blood pressure (BP) is associated with greater left ventricular mass indexed to height2.7 (LVMi2.7) in adolescents. This study examined whether greater BP variability and reduced night-time dipping are associated with cardiac remodeling in a
Externí odkaz:
https://doaj.org/article/6c1a3bbc67b2454fb9be9bb20f2247cb
Publikováno v:
eLife, Vol 8 (2019)
The age of large-scale genome-wide association studies (GWAS) has provided us with an unprecedented opportunity to evaluate the genetic liability of complex disease using polygenic risk scores (PRS). In this study, we have analysed 162 PRS (p
Externí odkaz:
https://doaj.org/article/5169542c83ac48be8f4f819bdcdd6adb
Publikováno v:
PLoS ONE, Vol 12, Iss 3, p e0173068 (2017)
BACKGROUND:Cash transfers and vouchers are forms of 'demand-side financing' that have been widely used to promote maternal and newborn health in low- and middle-income countries during the last 15 years. METHODS:This systematic review consolidates ev
Externí odkaz:
https://doaj.org/article/519300c4c3424da8ac15d0dae8042d8a
Autor:
Stian Kogler, Aleksandra Aizenshtadt, Sean Harrison, Frøydis Sved Skottvoll, Henriette Engen Berg, Shadab Abadpour, Hanne Scholz, Gareth Sullivan, Bernd Thiede, Elsa Lundanes, Inger Lise Bogen, Stefan Krauss, Hanne Røberg-Larsen, Steven Ray Wilson
Publikováno v:
Analytical Chemistry. 94:17677-17684
Organoids, i.e. laboratory-grown organ models developed from stem cells, are emerging tools for studying organ physiology, disease modeling and drug development. On-line analysis of organoids with mass spectrometry would provide analytical versatilit
Autor:
Richard M. Martin, Rachel Thompson, Martin Wiseman, Giota Mitrou, Kate Northstone, Mona Jeffreys, Pauline Emmett, Cath Borwick, Vanessa Tan, Rosie J. Lennon, Sean Harrison, Steve Thomas, Sabina Rinaldi, Suzanne D. Turner, Claire M. Perks, Tom R. Gaunt, Jeff M.P. Holly, Julian Higgins, Mike Gardner, Sarah J. Lewis
Background: Human, animal, and cell experimental studies; human biomarker studies; and genetic studies complement epidemiologic findings and can offer insights into biological plausibility and pathways between exposure and disease, but methods for sy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::375fe0ed0c53137f94ed2a45051fb99d
https://doi.org/10.1158/1055-9965.c.6515535.v1
https://doi.org/10.1158/1055-9965.c.6515535.v1
Autor:
Richard M. Martin, Rachel Thompson, Martin Wiseman, Giota Mitrou, Kate Northstone, Mona Jeffreys, Pauline Emmett, Cath Borwick, Vanessa Tan, Rosie J. Lennon, Sean Harrison, Steve Thomas, Sabina Rinaldi, Suzanne D. Turner, Claire M. Perks, Tom R. Gaunt, Jeff M.P. Holly, Julian Higgins, Mike Gardner, Sarah J. Lewis
A guide to using the methodology
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc7ce2c4b8416abf5e21f9d9305ea811
https://doi.org/10.1158/1055-9965.22436694.v1
https://doi.org/10.1158/1055-9965.22436694.v1
BACKGROUNDCancer is associated with significant economic impacts. Quantifying the scale of these impacts is challenged by confounding variables that jointly influence both cancer status and economic outcomes such as healthcare costs and quality of li
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::42f7ca5ad759d504e5badacd31b77cb3
https://doi.org/10.1101/2023.02.06.23285521
https://doi.org/10.1101/2023.02.06.23285521