Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Sean H Lim"'
Autor:
Franziska Heckel, Anna H. Turaj, Hayden Fisher, H. T. Claude Chan, Michael J. E. Marshall, Osman Dadas, Christine A. Penfold, Tatyana Inzhelevskaya, C. Ian Mockridge, Diego Alvarado, Ivo Tews, Tibor Keler, Stephen A. Beers, Mark S. Cragg, Sean H. Lim
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-15 (2022)
Agonistic CD27 monoclonal antibodies can be used to enhance the efficacy of depleting antibodies such as anti-CTLA-4 in a colon adenocarcinoma tumour model. CD27 antibody agonism is dependent on isotype and epitope specificity.
Externí odkaz:
https://doaj.org/article/f7e2de2c168f4f2984754369dc482291
Autor:
Sean H. Lim, Kim M. Linton, Graham P. Collins, Joke Dhondt, Joshua Caddy, Liz Rossiter, Karan Vadher, Keira Fines, Laura E. Rogers, Diana Fernando, Louise Stanton, Andrew J. Davies, Peter W. M. Johnson, Gareth Griffiths
Publikováno v:
Trials, Vol 19, Iss 1, Pp 1-14 (2018)
Abstract Background Over 12,000 new cases of B-cell malignancies are diagnosed in the UK each year, with diffuse large B-cell lymphoma (DLBCL) and follicular lymphoma (FL) being the most common subtypes. Standard frontline therapy consists of immunoc
Externí odkaz:
https://doaj.org/article/aec02f5cc1384a15b0945013d6790d3f
Autor:
Jianzhu Chen, Mark S. Cragg, Stephen M. Thirdborough, Margaret Ashton-Key, Sean H. Lim, Stephen A. Beers, Martin J. Glennie, Heather Huet, Emma Lees, Matthew J. Meyer, Russell B. Foxall, Maneesh Singh, Christopher Fraser, Guangan Hu, Ali Roghanian
Therapy-resistant microenvironments represent a major barrier toward effective elimination of disseminated cancer. Many hematologic and solid tumors are resistant to therapeutic antibodies in the bone marrow (BM), but not in the periphery (e.g., sple
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22d951e86c274b457384ae93f3210f24
https://doi.org/10.1158/2326-6066.c.6549976
https://doi.org/10.1158/2326-6066.c.6549976
Autor:
Fiona A Pearce, Sean H Lim, Mary Bythell, Peter Lanyon, Rachel Hogg, Adam Taylor, Gillian Powter, Graham S Cooke, Helen Ward, Joseph Chilcot, Helen Thomas, Lisa Mumford, Stephen P McAdoo, Gavin J Pettigrew, Liz Lightstone, Michelle Willicombe
ObjectivesTo investigate the prevalence of spike-protein antibodies following at least 3 COVID-19 vaccine doses in immunocompromised individuals.DesignCross-sectional study using UK national disease registries of individuals with solid organ transpla
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::52abb4d0f2c0654b229eae32fd53ba7b
https://doi.org/10.1101/2023.02.09.23285649
https://doi.org/10.1101/2023.02.09.23285649
Autor:
Ratna Wijaya, Sean H. Lim
Publikováno v:
Nature Cancer. 4:5-6
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::195980af93a902324b86481aef18c383
https://doi.org/10.1038/s43018-022-00505-8
https://doi.org/10.1038/s43018-022-00505-8
Autor:
Sean H. Lim, Nicola Campbell, Beth Stuart, Marina Johnson, Debora Joseph-Pietras, Adam Kelly, Danielle Jeffrey, Anna H. Turaj, Kate Rolfvondenbaumen, Celine Galloway, Thomas Wynn, Adam R. Coleman, Benjamin Ward, Karen Long, Andrew T. Bates, Diana Ayres, Robert Lown, Janlyn Falconer, Oliver Brake, James Batchelor, Victoria Willimott, Anna Bowzyk Al-Naeeb, Lisa Robinson, Ann O’Callaghan, Graham P. Collins, Tobias Menne, Saul N. Faust, Christopher P. Fox, Matthew Ahearne, Peter W.M. Johnson, Andrew J. Davies, David Goldblatt
SUMMARYSARS-CoV-2 vaccination protects against COVID-19. Antibodies and antigen-specific T-cell responses against the spike domain can be used to measure vaccine immune response. Individuals with lymphoma have defects in humoral and cellular immunity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::05db81c23d3f376117b26a44fb620057
https://doi.org/10.1101/2021.12.08.21266760
https://doi.org/10.1101/2021.12.08.21266760
Autor:
Sean H. Lim, Beth Stuart, Debora Joseph-Pietras, Marina Johnson, Nicola Campbell, Adam Kelly, Danielle Jeffrey, Anna H. Turaj, Kate Rolfvondenbaumen, Celine Galloway, Thomas Wynn, Adam R. Coleman, Benjamin Ward, Karen Long, Helen Coleman, Carina Mundy, Andrew T. Bates, Diana Ayres, Robert Lown, Janlyn Falconer, Oliver Brake, James Batchelor, Victoria Willimott, Anna Bowzyk Al-Naeeb, Lisa Robinson, Ann O’Callaghan, Graham P. Collins, Tobias Menne, Saul N. Faust, Christopher P. Fox, Matthew Ahearne, Peter W. M. Johnson, Andrew J. Davies, David Goldblatt
Publikováno v:
Nature cancer. 3(5)
Patients with hematological malignancies are at increased risk of severe COVID-19 outcomes due to compromised immune responses, but the insights of these studies have been compromised due to intrinsic limitations in study design. Here we present the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e506cf0e53293f76d17683e1486ea5c1
https://pubmed.ncbi.nlm.nih.gov/35624336
https://pubmed.ncbi.nlm.nih.gov/35624336
Autor:
Franziska, Heckel, Anna H, Turaj, Hayden, Fisher, H T Claude, Chan, Michael J E, Marshall, Osman, Dadas, Christine A, Penfold, Tatyana, Inzhelevskaya, C Ian, Mockridge, Diego, Alvarado, Ivo, Tews, Tibor, Keler, Stephen A, Beers, Mark S, Cragg, Sean H, Lim
Publikováno v:
Communications biology. 5(1)
Agonistic CD27 monoclonal antibodies (mAb) have demonstrated impressive anti-tumour efficacy in multiple preclinical models but modest clinical responses. This might reflect current reagents delivering suboptimal CD27 agonism. Here, using a novel pan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::219a5e95181abdd2dadaf5cdafe03532
https://pubmed.ncbi.nlm.nih.gov/35288635
https://pubmed.ncbi.nlm.nih.gov/35288635
Autor:
Ann O'Callaghan, Andrew Davies, Marina Johnson, Nicola Campbell, Graham P. Collins, Peter Johnson, Sean H. Lim, Matthew J. Ahearne, David Goldblatt, Debora Joseph-Pietras, Christopher P. Fox
Publikováno v:
The Lancet. Haematology
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb3faf044c493add86f929abf52000bf
http://europepmc.org/articles/PMC8253538
http://europepmc.org/articles/PMC8253538
Autor:
Graham P. Collins, C. Mundy, P. Johnson, B. Maynard, A. Bates, David Goldblatt, H. Coleman, Matthew J. Ahearne, S. N. Faust, R. Lown, J. Falconer, Mark H. Johnson, Debora Joseph-Pietras, V. Willimott, Ann O'Callaghan, D. Muller, N. Wetherall, N. Campbell, Andrew Davies, T. Wynn, Christopher P. Fox, Sean H. Lim
Publikováno v:
Hematological Oncology
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f77d99e4277c8e346ccd888e086ac0d
http://europepmc.org/articles/PMC8426672
http://europepmc.org/articles/PMC8426672