Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Sean Germain"'
Autor:
Ravneet S Vohra, Donovan Lott, Sunita Mathur, Claudia Senesac, Jasjit Deol, Sean Germain, Roxanna Bendixen, Sean C Forbes, H Lee Sweeney, Glenn A Walter, Krista Vandenborne
Publikováno v:
PLoS ONE, Vol 10, Iss 6, p e0128915 (2015)
The primary objectives of this study were to evaluate contractile and non-contractile content of lower leg muscles of boys with Duchenne muscular dystrophy (DMD) and determine the relationships between non-contractile content and functional abilities
Externí odkaz:
https://doaj.org/article/210c26c8c71943639cef82550d3f0f20
Autor:
Holly Cossette, Harvey E Ramirez, Karl Andrutis, Thomas J. Conlon, Barry J. Byrne, Laurie M. Fiske, Sean Germain, Janice Y. Chou, Martha Campbell-Thompson, Karine Onclin-Verstegen, Gurmeet Dhaliwal, Stacy Porvasnik, Juan Jordan, Catherine E. Correia, Cathryn Mah, Andrew Specht, Maggie B. Struck, Darin J. Falk, Layla Mirian, J.P. Verstegen, Nathalie Clement, David A. Weinstein
Publikováno v:
Human Gene Therapy. 21:903-910
Glycogen storage disease type Ia (GSDIa; von Gierke disease; MIM 232200) is caused by a deficiency in glucose-6-phosphatase-alpha. Patients with GSDIa are unable to maintain glucose homeostasis and suffer from severe hypoglycemia, hepatomegaly, hyper
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e6cbc09b07f419b66b03ea1a59c17d7
https://doi.org/10.1089/hum.2009.157
https://doi.org/10.1089/hum.2009.157
Autor:
Donovan J. Lott, Sunita Mathur, Ravneet Vohra, Claudia R. Senesac, Glenn A. Walter, Sean Germain, Krista Vandenborne, H. Lee Sweeney
Publikováno v:
Archives of Physical Medicine and Rehabilitation. 91:1051-1058
Mathur S, Lott DJ, Senesac C, Germain SA, Vohra RS, Sweeney HL, Walter GA, Vandenborne K. Age-related differences in lower-limb muscle cross-sectional area and torque production in boys with Duchenne muscular dystrophy. Objective To examine the relat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49936cd3fb008066a11c79897db6b5cc
https://doi.org/10.1016/j.apmr.2010.03.024
https://doi.org/10.1016/j.apmr.2010.03.024
Autor:
Kerry O. Cresawn, Melissa A. Lewis, Martha Campbell-Thompson, Barry J. Byrne, Jeffry S. Kelley, Sean Germain, Denise A. Cloutier, Thomas J. Conlon, Darin J. Falk, David D. Fuller, Cathryn Mah, Thomas J. Fraites, Lara R. DeRuisseau
Publikováno v:
Molecular Therapy. 18:502-510
Pompe disease is a muscular dystrophy that results in respiratory insufficiency. We characterized the outcomes of targeted delivery of recombinant adeno-associated virus serotype 1 (rAAV2/1) vector to diaphragms of Pompe mice with varying stages of d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1da3eb92682c30bef5a153ecc148f70e
https://doi.org/10.1038/mt.2009.305
https://doi.org/10.1038/mt.2009.305
Autor:
Glenn A. Walter, Krista Vandenborne, Sean Germain, H. Lee Sweeney, Sean C. Forbes, Donovan J. Lott, Sunita Mathur, Claudia R. Senesac
The purpose of this study was to use proton magnetic resonance spectroscopy to assess intramuscular lipid and metabolites of lower leg muscles in boys with Duchenne muscular dystrophy (DMD) and determine its relationship with strength and functional
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ba3ffe9a2dae79e56878de47e08bab7
https://europepmc.org/articles/PMC4142654/
https://europepmc.org/articles/PMC4142654/
Autor:
Krista Vandenborne, Hiroshi Akima, H. Lee Sweeney, Roxanna M. Bendixen, Glenn A. Walter, Sean Germain, Claudia R. Senesac, Ishu Arpan, Donovan J. Lott, Jasjit Deol
The purpose of this study was to assess the contractile and non-contractile content in thigh muscles of patients with Duchenne muscular dystrophy (DMD) and determine the relationship with functional abilities. Magnetic resonance images of the thigh w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb61df009aa87c1d60ff8a21cadbbca9
https://europepmc.org/articles/PMC3215817/
https://europepmc.org/articles/PMC3215817/
Autor:
Nathan Bryant, Krista Vandenborne, Glenn A. Walter, Ravneet Vohra, Sean C. Forbes, Sunita Mathur, Sean Germain
Publikováno v:
Musclenerve. 43(6)
Introduction—This study compared the effects of downhill or horizontal treadmill running on the magnetic resonance imaging (MRI) transverse relaxation time constant (T2) in mdx mice. Methods—Mice underwent either downhill (n=11 mdx, n=6 controls)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e488fbe1b7eb677f2af73395d0b062e
https://pubmed.ncbi.nlm.nih.gov/21488051
https://pubmed.ncbi.nlm.nih.gov/21488051
Autor:
Stacy Porvasnik, Faris M Al-Mousily, Vincent Jacques, Jennifer E. Embury, Gannon Kimberley S, Barry J. Byrne, Sean Germain, Sharon Shacham, Justin Murray
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 334(2)
Pulmonary arterial hypertension (PAH) is a life-threatening disease that results in right ventricular failure. 5-((4-(6-Chlorothieno[2,3-d]pyrimidin-4-ylamino)piperidin-1-yl)methyl)-2-fluorobenzonitrile monofumarate (PRX-08066) is a selective 5-hydro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9544765fd5bd2ae8a21ef648654784ab
https://pubmed.ncbi.nlm.nih.gov/20430844
https://pubmed.ncbi.nlm.nih.gov/20430844
Autor:
Ronald G. Haller, Sean Germain, M. Anthony Verity, Krista Vandenborne, Elena Kudryashova, Nadine Romain, Irina Kramerova, Melissa J. Spencer, Benjamin G. Wu
Publikováno v:
Human molecular genetics. 18(17)
Mutations in the non-lysosomal cysteine protease calpain-3 cause autosomal recessive limb girdle muscular dystrophy. Pathological mechanisms occurring in this disease have not yet been elucidated. Here, we report both morphological and biochemical ev
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60477e07ac6c1c7b9b88a01fd4c50e08
https://pubmed.ncbi.nlm.nih.gov/19483197
https://pubmed.ncbi.nlm.nih.gov/19483197
Autor:
Martha Campbell-Thompson, Thomas J. Conlon, Eric S. Goetzman, Dietrich Matern, Terence R. Flotte, Stuart G. Beattie, Jerry Vockley, Sean Germain, Glenn A. Walter
Recombinant adeno-associated viral vectors pseudotyped with serotype 5 and 8 capsids (AAV5 and AAV8) have been shown to be efficient gene transfer reagents for the liver. We have produced AAV5 and AAV8 vectors that express mouse short-chain acyl-CoA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f37c98014bad0cf5164e53442b10e115
https://europepmc.org/articles/PMC2940548/
https://europepmc.org/articles/PMC2940548/