Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Sean Gardner"'
Autor:
Anrieta Karapetyan, Sean Gardner
Publikováno v:
Banber Erevani Hamalsarani. Sots'iologia, Vol 14, Iss 2 (38) (2023)
Online is one of the main types of communication and relationship building. Social networking site users are increasing day by day, not only in Armenia but worldwide. Currently, debates are actively underway about the impact of online communication o
Externí odkaz:
https://doaj.org/article/5c9775e564bf4c098f55cc50a634ddc7
Publikováno v:
Organic Letters. 19:3680-3683
Boron-hydrogen bond insertion reactions of N-heterocyclic carbene (NHC) boranes and diazoesters can be catalyzed by NHC-boryl iodides and produce stable α-NHC-boryl esters. The conditions of the reaction resemble the previous rhodium-catalyzed trans
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fbbf558ffc38026fc742827c61d0cfa9
https://doi.org/10.1021/acs.orglett.7b01777
https://doi.org/10.1021/acs.orglett.7b01777
Publikováno v:
Organic Syntheses
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e7da4cbe40a1a5aabe7079a1adc74f92
https://doi.org/10.1002/0471264229.os092.26
https://doi.org/10.1002/0471264229.os092.26
Autor:
Jay Moon, Franklyn Ngundam, Erin Milner, Erin Harris, Sandi Parriott, Richard J. Sciotti, Brittney Potter, Qigui Li, Patricia J. Lee, Michael T. O’Neil, Michael P. Kozar, Sean Gardner, Diana Caridha, Jennifer M. Auschwitz, Anchalee Tangteung, Kristina Grauer, Mark Hickman, Geoffrey S. Dow, Susan E. Leed, Jason C. Sousa, Brandon S. Pybus, Victor Melendez
Publikováno v:
European Journal of Drug Metabolism and Pharmacokinetics. 37:17-22
Ketotifen is known to exhibit antimalarial activity in mouse and monkey malaria models. However, the low plasma levels and short half life of the drug do not adequately explain its in vivo efficacy. We synthesized most of the known metabolites of ket
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fff844de657e2fb34fa0cd6b909b0398
https://doi.org/10.1007/s13318-012-0080-2
https://doi.org/10.1007/s13318-012-0080-2
Publikováno v:
The Journal of organic chemistry. 80(19)
1,3-Dialkylimidazol-2-ylidene boranes have been made in moderate yields (typically 23–53%) from the corresponding N-alkyl imidazole, an alkylating agent (usually MeI), and sodium borohydride (NaBH4). The two-step, one-pot reaction sequence takes ab
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb16b87272182a87540584e10e73a1b5
https://pubmed.ncbi.nlm.nih.gov/26334670
https://pubmed.ncbi.nlm.nih.gov/26334670
Autor:
Geoffrey S. Dow, Diana Caridha, Sean Reyes, Anchalee Tungteung, Jacob D. Johnson, William McCalmont, Bryan Smith, Norma Roncal, Qiang Zeng, Patricia J. Lee, Sean Gardner, Erin Milner, Victor Melendez, Jennifer M. Auschwitz, Jay Moon, Jason C. Sousa, Dustin Carroll, Michael P. Kozar, Qigui Li
Publikováno v:
European journal of drug metabolism and pharmacokinetics. 39(4)
The use of mefloquine (MQ) for antimalarial treatment and prophylaxis has diminished largely in response to concerns about its neurologic side effects. An analog campaign designed to maintain the efficacy of MQ while minimizing blood–brain barrier
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52f5be18393e415a9a6e6fed9c6bee93
https://pubmed.ncbi.nlm.nih.gov/24705994
https://pubmed.ncbi.nlm.nih.gov/24705994
Autor:
Lucia Gerena, Richard J. Sciotti, Qigui Li, Bryan Smith, Erin Milner, Victor Melendez, Norma Roncal, Ian Bathurst, Jennifer M. Auschwitz, Jason C. Sousa, Geoffrey S. Dow, Susan E. Leed, Michael P. Kozar, Jacob D. Johnson, William McCalmont, Sean Gardner, Anchalee Tungtaeng, Jay Moon, Peter Wipf, Montip Gettayacamin, Patricia J. Lee, Diana Caridha, Kristina Grauer
Publikováno v:
Journal of medicinal chemistry. 54(18)
A library of diamine quinoline methanols were designed based on the mefloquine scaffold. The systematic variation of the 4-position amino alcohol side chain led to analogues that maintained potency while reducing accumulation in the central nervous s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b74ea79cbda2595143e6bda57a4d0a1
https://pubmed.ncbi.nlm.nih.gov/21854078
https://pubmed.ncbi.nlm.nih.gov/21854078
Autor:
Anne Mannila, Jayendra B. Bhonsle, William McCalmont, Michael P. Kozar, Qiang Zeng, Erin Milner, Ian Bathurst, Geoffrey S. Dow, Charlotte A. Lanteri, Kevin D. Read, Jessica Anne Steuten, Suzanne Norval, Jay Moon, Sean Gardner, Karen L. White, Jason C. Sousa, Norma Roncal, David M. Shackleford, Lucia Gerena, Susan A. Charman, Diana Caridha
Publikováno v:
Malaria Journal, Vol 10, Iss 1, p 150 (2011)
Malaria Journal
Malaria Journal
Background The clinical use of mefloquine (MQ) has declined due to dose-related neurological events. Next generation quinoline methanols (NGQMs) that do not accumulate in the central nervous system (CNS) to the same extent may have utility. In this s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::026f0d8ebf2a9c4bd476d4f8f9194cdc
https://doi.org/10.1186/1475-2875-10-150
https://doi.org/10.1186/1475-2875-10-150
Autor:
Jason C. Sousa, William McCalmont, Qiang Zeng, Erin Milner, Dustin Carroll, Jennifer M. Auschwitz, Patricia J. Lee, Michael P. Kozar, Sean Gardner, Jay Moon, Brandon S. Pybus, Anchalee Tungtaeng, Kevin D. Read, Qigui Li, Victor Melendez, Montip Gettayacamin, Kristina Grauer, Suzanne Norval, Geoffrey S. Dow, Susan E. Leed
Publikováno v:
European journal of drug metabolism and pharmacokinetics. 36(3)
WR319691 has been shown to exhibit reasonable Plasmodium falciparum potency in vitro and exhibits reduced permeability across MDCK cell monolayers, which as part of our screening cascade led to further in vivo analysis. Single-dose pharmacokinetics w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f50feabf923bd8c6c22d2b6e3148b31
https://pubmed.ncbi.nlm.nih.gov/21751074
https://pubmed.ncbi.nlm.nih.gov/21751074