The Haemonchus contortus LGC-39 subunit is a novel subtype of an acetylcholine-gated chloride channel

Autor: Sarah Habibi, Kristen Nazareth, Jennifer Nichols, Sierra Varley, Sean G. Forrester

Publikováno v: International Journal for Parasitology: Drugs and Drug Resistance, Vol 22, Iss , Pp 20-26 (2023)

The nematode genome exhibits a vast array of Cys-loop receptors that are activated by a diverse set of neurotransmitters and anthelmintic drugs such as ivermectin and levamisole. While many Cys-loop receptors have been functionally and pharmacologica

Externí odkaz: https://doaj.org/article/7f30be9b05084894a4f7eaf10b5f88b6

A mutational and molecular dynamics study of the cys-loop GABA receptor Hco-UNC-49 from Haemonchus contortus: Agonist recognition in the nematode GABA receptor family

Autor: Josh Foster, Everett Cochrane, Mohammad Hassan Khatami, Sarah A. Habibi, Hendrick de Haan, Sean G. Forrester

Publikováno v: International Journal for Parasitology: Drugs and Drug Resistance, Vol 8, Iss 3, Pp 534-539 (2018)

The UNC-49 receptor is a unique nematode γ-aminobutyric acid (GABA)-gated chloride channel that may prove to be a novel target for the development of nematocides. Here we have characterized various charged amino acid residues in and near the agonist

Externí odkaz: https://doaj.org/article/acec6c0167ff4636b3902b68361d8d83

Characterization of adjacent charged residues near the agonist binding site of the nematode UNC-49 GABA receptor

Autor: Everett Cochrane, Joshua Foster, Mohammad Hassan Khatami, Hendrick W. de Haan, Sean G. Forrester

Publikováno v: Molecular and biochemical parasitology. 252

The UNC-49 receptor is a Cys-loop GABA receptor that is unique to the nematode phylum. The receptor differs from mammalian GABA receptors both in amino acid sequence and pharmacology which highlights its potential as a novel anthelmintic target. Sequ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d4950f67e4a579d18b03459f3379324
https://pubmed.ncbi.nlm.nih.gov/36100173

Investigating the function and possible biological role of an acetylcholine-gated chloride channel subunit (ACC-1) from the parasitic nematode Haemonchus contortus

Autor: Kristen Nazareth, Wen Jing Law, Richard L. Komuniecki, Sarah A. Habibi, Micah K. Callanan, Sean G. Forrester

Publikováno v: International Journal for Parasitology: Drugs and Drug Resistance
International Journal for Parasitology: Drugs and Drug Resistance, Vol 8, Iss 3, Pp 526-533 (2018)

The cys-loop superfamily of ligand-gated ion channels are well recognized as important drug targets for many invertebrate specific compounds. With the rise in resistance seen worldwide to existing anthelmintics, novel drug targets must be identified

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46e18d93c6e22f025d7382d8002d3ae9
http://europepmc.org/articles/PMC6287539

Molecular Characterization of Binding Loop E in the Nematode Cys-Loop GABA Receptor

Autor: Ariel Kwaka, Hendrick W. de Haan, Everett Cochrane, Joshua Foster, Sean G. Forrester, Sarah A. Habibi, Mohammad Hassan Khatami

Publikováno v: Molecular pharmacology. 94(5)

Nematodes exhibit a vast array of cys-loop ligand-gated ion channels with unique pharmacologic characteristics. However, many of the structural components that govern the binding of various ligands are unknown. The nematode cys-loop GABA receptor unc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0af169a1c72a11d2dd1285fd85140b7d
https://pubmed.ncbi.nlm.nih.gov/30194106