Zobrazeno 1 - 10
of 44
pro vyhledávání: '"Sean G Rudd"'
Autor:
Sean G Rudd, Nikolaos Tsesmetzis, Kumar Sanjiv, Cynthia BJ Paulin, Lakshmi Sandhow, Juliane Kutzner, Ida Hed Myrberg, Sarah S Bunten, Hanna Axelsson, Si Min Zhang, Azita Rasti, Petri Mäkelä, Si'Ana A Coggins, Sijia Tao, Sharda Suman, Rui M Branca, Georgios Mermelekas, Elisée Wiita, Sun Lee, Julian Walfridsson, Raymond F Schinazi, Baek Kim, Janne Lehtiö, Georgios Z Rassidakis, Katja Pokrovskaja Tamm, Ulrika Warpman‐Berglund, Mats Heyman, Dan Grandér, Sören Lehmann, Thomas Lundbäck, Hong Qian, Jan‐Inge Henter, Torsten Schaller, Thomas Helleday, Nikolas Herold
Publikováno v:
EMBO Molecular Medicine, Vol 12, Iss 3, Pp 1-20 (2020)
Abstract The deoxycytidine analogue cytarabine (ara‐C) remains the backbone treatment of acute myeloid leukaemia (AML) as well as other haematological and lymphoid malignancies, but must be combined with other chemotherapeutics to achieve cure. Yet
Externí odkaz:
https://doaj.org/article/ee94cd1a0d794c99b66c9335300d2f1e
Autor:
Miriam Yagüe-Capilla, Sean G. Rudd
Publikováno v:
Disease Models & Mechanisms, Vol 17, Iss 8 (2024)
Externí odkaz:
https://doaj.org/article/a9e5c8a9c2f34d0ea04b807185845130
Autor:
Si Min Zhang, Cynthia B.J. Paulin, Huazhang Shu, Miriam Yagüe-Capilla, Maurice Michel, Petra Marttila, Florian Ortis, Henri Colyn Bwanika, Christopher Dirks, Rajagopal Papagudi Venkatram, Elisée Wiita, Ann-Sofie Jemth, Ingrid Almlöf, Olga Loseva, Femke M. Hormann, Tobias Koolmeister, Erika Linde, Sun Lee, Sabin Llona-Minguez, Martin Haraldsson, Hanna Axelsson, Kia Strömberg, Evert J. Homan, Martin Scobie, Thomas Lundbäck, Thomas Helleday, Sean G. Rudd
Publikováno v:
iScience, Vol 27, Iss 2, Pp 108907- (2024)
Summary: SAMHD1 is a dNTP triphosphohydrolase governing nucleotide pool homeostasis and can detoxify chemotherapy metabolites controlling their clinical responses. To understand SAMHD1 biology and investigate the potential of targeting SAMHD1 as neoa
Externí odkaz:
https://doaj.org/article/62a8b016c8c04843b50875f18c4706f6
Publikováno v:
PeerJ, Vol 10, p e13141 (2022)
Objective The survival and clinicopathological significance of desmoglein 2 (DSG2) in various cancers is controversial. Thus, we performed this systematic review and meta-analysis to explore the preliminary prognostic value of DSG2. Methods Eligible
Externí odkaz:
https://doaj.org/article/5f05ff14158e45748c4273fa07e6ea64
Autor:
Si Min Zhang, Cynthia B.J. Paulin, Maurice Michel, Petra Marttila, Miriam Yagüe-Capilla, Henri Colyn Bwanika, Huazhang Shu, Rajagopal Papagudi Vekatram, Elisée Wiita, Ann-Sofie Jemth, Ingrid Almlöf, Olga Loseva, Florian Ortis, Christopher Dirks, Tobias Koolmeister, Erika Linde, Sun Lee, Sabin Llona-Minguez, Martin Haraldsson, Kia Strömberg, Evert J. Homan, Martin Scobie, Thomas Lundbäck, Thomas Helleday, Sean G. Rudd
Sterile alpha motif and histidine-aspartic acid domain containing protein-1 (SAMHD1) is a deoxynucleoside triphosphate (dNTP) triphosphohydrolase central to cellular nucleotide pool homeostasis. Recent literature has also demonstrated how SAMHD1 can
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d18528c03f820b941db5dd13e66d5a66
https://doi.org/10.1101/2023.01.17.524275
https://doi.org/10.1101/2023.01.17.524275
Publikováno v:
Molecular & Cellular Oncology, Vol 4, Iss 2 (2017)
The outcome of acute myelogenous leukemia (AML) therapy depends on the propensity of leukemic blasts to accumulate ara-CTP, the active triphosphate of cytarabine (ara-C). We identified sterile α motif and HD domain-containing protein 1 (SAMHD1) as a
Externí odkaz:
https://doaj.org/article/68a26a83d155424f8eda9c36528bae5a
Autor:
Sophia Ceder, Sofi E. Eriksson, Ying Yu Liang, Emarndeena H. Cheteh, Si Min Zhang, Kenji M. Fujihara, Julie Bianchi, Vladimir J. N. Bykov, Lars Abrahmsen, Nicholas J. Clemons, Pär Nordlund, Sean G. Rudd, Klas G. Wiman
Publikováno v:
Cell Death & Disease. 13
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::864e0f2c7cd79cb906343833affbfc11
https://doi.org/10.1038/s41419-022-05130-y
https://doi.org/10.1038/s41419-022-05130-y
Autor:
Saeed Eshtad, Ingrid Almlöf, Pål Stenmark, Matthieu Desroses, Armando Cázares-Körner, Evert Homan, Mikael Altun, Azita Rasti, Si Min Zhang, Torsten Schaller, Lars Bräutigam, Hanna Axelsson, Megan Carter, Adam Throup, Rosa Krimpenfort, Tobias Koolmeister, Daniel Rehling, Ann-Sofie Jemth, Thomas Lundbäck, Elisee Wiita, Thomas Helleday, Anna Hagenkort, Brent D. G. Page, Martin Scobie, Ulrika Warpman Berglund, Linda Pudelko, Antonio Sarno, Andreas Krämer, Christina Kalderén, Juliane Kutzner, Olov A. Wallner, Shruti Regmi, Mona Göttmann, Sean G. Rudd, Nicholas C.K. Valerie, Stefan Knapp, Olga Loseva
Publikováno v:
Nature chemical biology
Nature Chemical Biology
Nature Chemical Biology
The NUDIX hydrolase NUDT15 was originally implicated in sanitizing oxidized nucleotides but was later shown to hydrolyze the active thiopurine metabolites, 6-thio-(d)GTP, thereby dictating the clinical response of this standard-of-care treatment for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56c67aef4c81a65cb8722945b628f211
http://europepmc.org/articles/PMC7610571
http://europepmc.org/articles/PMC7610571
Autor:
Miriam, Yagüe-Capilla, Sean G, Rudd
Publikováno v:
Journal of visualized experiments : JoVE. (170)
Sterile alpha motif and HD domain-containing protein 1 (SAMHD1) is a pivotal regulator of intracellular deoxynucleoside triphosphate (dNTP) pools, as this enzyme can hydrolyze dNTPs into their corresponding nucleosides and inorganic triphosphates. Du
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::3d795aa73df3cab66423591275917892
https://pubmed.ncbi.nlm.nih.gov/33938897
https://pubmed.ncbi.nlm.nih.gov/33938897
Autor:
Daniel, Rehling, Si Min, Zhang, Ann-Sofie, Jemth, Tobias, Koolmeister, Adam, Throup, Olov, Wallner, Emma, Scaletti, Takaya, Moriyama, Rina, Nishii, Jonathan, Davies, Matthieu, Desroses, Sean G, Rudd, Martin, Scobie, Evert, Homan, Ulrika Warpman, Berglund, Jun J, Yang, Thomas, Helleday, Pål, Stenmark
Publikováno v:
The Journal of Biological Chemistry
The enzyme NUDT15 efficiently hydrolyzes the active metabolites of thiopurine drugs, which are routinely used for treating cancer and inflammatory diseases. Loss-of-function variants in NUDT15 are strongly associated with thiopurine intolerance, such
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::130f97052116c35583832066329748df
https://pubmed.ncbi.nlm.nih.gov/33753169
https://pubmed.ncbi.nlm.nih.gov/33753169