Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Sean G, Brown"'
Autor:
Zoe C Johnston, Franz S Gruber, Sean G Brown, Neil R Norcross, Jason Swedlow, Ian H Gilbert, Christopher L R Barratt
Publikováno v:
Reproduction. 163:R1-R9
Despite recent advances in male reproductive health research, there remain many elements of male infertility where our understanding is incomplete. Consequently, diagnostic tools and treatments for men with sperm dysfunction, other than medically ass
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7c3cdc8c42bf735f0bf15888dad18ae
https://doi.org/10.1530/rep-21-0372
https://doi.org/10.1530/rep-21-0372
Autor:
Johan M. Campbell, Anne L. Savage, Oladipo Madamidola, Kshitij Tamhane, Renalyn Soriano, Ashok K. Adya, Sean G. Brown
Publikováno v:
BioDiscovery, Vol 9, Iss , Pp 1-7 (2013)
Progesterone released from the cumulus cells of the oocyte causes a number of physiological responses in human sperm cells including hyperactivation, acrosome reaction and chemotaxis. We employed a validated sperm mobility assay, which involves measu
Externí odkaz:
https://doaj.org/article/388125e8d80d48cc9a416375b97b96fe
Autor:
Richard Sawatzky, Marilyn Mulldoon, Nitya Suryaprakash, Stirling Bryan, Mary M. Doyle-Waters, Sean G. Brown, Moira Le Mercier, Rajiv Gandhi, Linda C. Li, Satwinder Kaur Bains, Laurie J. Goldsmith, David Moorthy
Publikováno v:
CMAJ Open. 8:E226-E233
Background Up to 1 in 5 patients who undergo total knee arthroplasty (TKA) express dissatisfaction with their surgery. Our goal was to understand the experiences of patients of South Asian origin who undergo TKA and to identify a research agenda for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f519d8a1170fbf1859e36242874eb763
https://doi.org/10.9778/cmajo.20190128
https://doi.org/10.9778/cmajo.20190128
Autor:
Sarah Martins da Silva, David W. Gray, Joanna Fraser, Sean G. Brown, Rachel C. McBrinn, Anthony G. Hope, Christopher L.R. Barratt
Publikováno v:
British Journal of Pharmacology
Background and purpose Asthenozoospermia is a leading cause of male infertility, but development of pharmacological agents to improve sperm motility is hindered by the lack of effective screening platforms and knowledge of suitable molecular targets.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e174bd91283380fd79d7f3128f4ff7d4
http://europepmc.org/articles/PMC6932944
http://europepmc.org/articles/PMC6932944
Publikováno v:
Human Reproduction Update
BACKGROUNDIntensive research on sperm ion channels has identified members of several ion channel families in both mouse and human sperm. Gene knock-out studies have unequivocally demonstrated the importance of the calcium and potassium conductances i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4f70f8bf53cbcb94cbca876ba8e52fd
http://europepmc.org/articles/PMC6847974
http://europepmc.org/articles/PMC6847974
Autor:
Priyanka Prajapati, Shruti Kane, Rachel C. McBrinn, Morven S. Dean, Sarah J. Martins da Silva, Sean G. Brown
Publikováno v:
International Journal of Molecular Sciences; Volume 23; Issue 19; Pages: 11253
Progesterone and prostaglandin E1 are postulated to trigger the human sperm acrosome reaction (AR). However, their reported efficacy is very variable which likely, in part, reflects the plethora of experimental conditions and methodologies used to de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f77307690829bf773b7b6bf5e67f251
https://doi.org/10.3390/ijms231911253
https://doi.org/10.3390/ijms231911253
Autor:
Christopher L.R. Barratt, Sean G. Brown, S. M. Martins da Silva, S. J. Publicover, P. V. Lishko
Publikováno v:
XIIIth International Symposium on Spermatology ISBN: 9783030662912
Background: CatSper is a multi-subunit sperm-specific calcium channel that mediates the progesterone-induced increase in intracellular calcium. Evidence from CatSper subunit knock-out mouse models implicates it as essential for sperm fertilisation co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c4863d8dd01e0a2791ed944aa98c0814
https://doi.org/10.1007/978-3-030-66292-9_46
https://doi.org/10.1007/978-3-030-66292-9_46
Autor:
Claudia L. Treviño, Christopher L.R. Barratt, Sean G. Brown, Elis Torrezan-Nitao, Esperanza Mata-Martínez, Stephen J. Publicover
Publikováno v:
Human reproduction (Oxford, England). 36(2)
STUDY QUESTION How are progesterone (P4)-induced repetitive intracellular Ca2+ concentration ([Ca2+]i) signals (oscillations) in human sperm generated? SUMMARY ANSWER P4-induced [Ca2+]i oscillations are generated in the flagellum by membrane potentia
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd24d6daa9c8e145bc059aa218445bdc
https://pubmed.ncbi.nlm.nih.gov/33305795
https://pubmed.ncbi.nlm.nih.gov/33305795
Autor:
Satoshi Tasumi, Chiguang Feng, Lai-Xi Wang, Brina Smith, Gerardo R. Vasta, Sean G. Brown, Muddasar Iqbal, Mario A. Bianchet, Aren Vista, Katharina Paschinger, Kelsey Abernathy, Iain B. H. Wilson, Anita Ghosh, Mohammed N. Amin
Publikováno v:
Frontiers in Chemistry, Vol 8 (2020)
Frontiers in Chemistry
Frontiers in Chemistry
Both vertebrates and invertebrates display active innate immune mechanisms for defense against microbial infection, including diversified repertoires of soluble and cell-associated lectins that can effect recognition and binding to potential pathogen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fea5fd251d3d94cc7ccd63f1a023769a
https://www.frontiersin.org/article/10.3389/fchem.2020.00098/full
https://www.frontiersin.org/article/10.3389/fchem.2020.00098/full
Autor:
Sean G, Brown, Melissa R, Miller, Polina V, Lishko, Douglas H, Lester, Stephen J, Publicover, Christopher L R, Barratt, Sarah, Martins Da Silva
Publikováno v:
Human Reproduction (Oxford, England)
STUDY QUESTION Does a man (patient 1) with a previously described deficiency in principle cation channel of sperm (CatSper) function have a mutation in the CatSper-epsilon (CATSPERE) and/or CatSper-zeta (CATSPERZ) gene? SUMMARY ANSWER Patient 1 has a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::12927d5ddb8dd6f4483f3dfe2e6260ba
https://pubmed.ncbi.nlm.nih.gov/30239785
https://pubmed.ncbi.nlm.nih.gov/30239785