Zobrazeno 1 - 10
of 155
pro vyhledávání: '"Sean F. Brady"'
Autor:
Vincent Libis, Logan W. MacIntyre, Rabia Mehmood, Liliana Guerrero, Melinda A. Ternei, Niv Antonovsky, Ján Burian, Zongqiang Wang, Sean F. Brady
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-10 (2022)
Efficient mobilization and expression of biosynthetic gene clusters (BGCs) into heterologous hosts is needed for microbial natural products discovery. Here, the authors improve the CONKAT-seq strategy by simultaneously capturing the BCGs into a singl
Externí odkaz:
https://doaj.org/article/bf50f0e3f20d48b3a29e45a4676ef6ac
Autor:
Louis J. Cohen, Sun M. Han, Pearson Lau, Daniela Guisado, Yupu Liang, Toshiki G. Nakashige, Thamina Ali, David Chiang, Adeeb Rahman, Sean F. Brady
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-12 (2022)
Lectins are non-enzymatic carbohydrate binding proteins important to human cellular functions. Here, the authors characterize a lectin produced by a human associated bacterium, and show that interacts with myeloid cells in the blood and intestine, su
Externí odkaz:
https://doaj.org/article/1df5145a09fe429d8021a79dc2379add
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-9 (2022)
Chemical synthesis of secondary metabolites isolated from nature, and derivatives thereof, is still a paradigm of significance to drug development. Here the authors instead use bioinformatics to analyze a biosynthetic gene cluster found in the soil m
Externí odkaz:
https://doaj.org/article/907f3ef3a9824f6891e0f4fae08900a7
Autor:
Frank J. Piscotta, Hans-Heinrich Hoffmann, Young Joo Choi, Gabriel I. Small, Alison W. Ashbrook, Bimal Koirala, Elizabeth A. Campbell, Seth A. Darst, Charles M. Rice, Sean F. Brady
Publikováno v:
mSphere, Vol 6, Iss 6 (2021)
ABSTRACT The COVID-19 pandemic has highlighted the need to identify additional antiviral small molecules to complement existing therapies. Although increasing evidence suggests that metabolites produced by the human microbiome have diverse biological
Externí odkaz:
https://doaj.org/article/b1866295b89c43e5b7d805cf12594bc0
Autor:
Frank J. Piscotta, Shawn T. Whitfield, Toshiki G. Nakashige, Andreia B. Estrela, Thahmina Ali, Sean F. Brady
Publikováno v:
Cell Reports, Vol 36, Iss 12, Pp 109746- (2021)
Summary: The human microbiota plays a critical role in host health. Proper development of the infant microbiome is particularly important. Its dysbiosis leads to both short-term health issues and long-term disorders lasting into adulthood. A central
Externí odkaz:
https://doaj.org/article/4f332560ce144da4821cde24d9a701af
Autor:
Vincent Libis, Niv Antonovsky, Mengyin Zhang, Zhuo Shang, Daniel Montiel, Jeffrey Maniko, Melinda A. Ternei, Paula Y. Calle, Christophe Lemetre, Jeremy G. Owen, Sean F. Brady
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-9 (2019)
Soil microorganisms are a rich source of bioactive molecules. Here, the authors present a targeted sequencing workflow that reconstructs the clustered organization of biosynthetic domains in metagenomic libraries from amplicon data, thus guiding the
Externí odkaz:
https://doaj.org/article/2be2b1b1e1544062afa735e20fcd1c7b
Publikováno v:
mSystems, Vol 5, Iss 6 (2020)
ABSTRACT Polyketides (PKs) and nonribosomal peptides (NRPs) are two microbial secondary metabolite (SM) families known for their variety of functions, including antimicrobials, siderophores, and others. Despite their involvement in bacterium-bacteriu
Externí odkaz:
https://doaj.org/article/982dd7d256ca474c85fc630549087465
Autor:
James Peek, Mirjana Lilic, Daniel Montiel, Aleksandr Milshteyn, Ian Woodworth, John B. Biggins, Melinda A. Ternei, Paula Y. Calle, Michael Danziger, Thulasi Warrier, Kohta Saito, Nathaniel Braffman, Allison Fay, Michael S. Glickman, Seth A. Darst, Elizabeth A. Campbell, Sean F. Brady
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
Resistance to rifamycin antibiotics, which target bacterial RNA polymerases, is a growing problem. Here, the authors identify gene clusters from soil metagenomes encoding production of rifamycin analogues that are active against rifampicin-resistant
Externí odkaz:
https://doaj.org/article/9a2754d11dc34b7e92b8fd4db1a27cbf
Autor:
Andreia B. Estrela, Toshiki G. Nakashige, Christophe Lemetre, Ian D. Woodworth, Jazz L. Weisman, Louis J. Cohen, Sean F. Brady
Publikováno v:
mBio, Vol 10, Iss 6 (2019)
ABSTRACT The effect of the microbiota on its human host is driven, at least in part, by small-molecule and protein effectors it produces. Here, we report on the use of functional multigenomic screening to identify microbiota-encoded effectors. In thi
Externí odkaz:
https://doaj.org/article/c30310d16176471586d2970fd4e6b38e
Autor:
Ján Burian, Vincent K. Libis, Yozen A. Hernandez, Liliana Guerrero-Porras, Melinda A. Ternei, Sean F. Brady
Publikováno v:
Nature Biotechnology. 41:626-630
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e8860072fce4c000d7f8d9b7f932f363
https://doi.org/10.1038/s41587-022-01531-8
https://doi.org/10.1038/s41587-022-01531-8