Zobrazeno 1 - 10
of 86
pro vyhledávání: '"Sean F Monaghan"'
Autor:
Christy L Rhine, Kamil J Cygan, Rachel Soemedi, Samantha Maguire, Michael F Murray, Sean F Monaghan, William G Fairbrother
Publikováno v:
PLoS Genetics, Vol 14, Iss 3, p e1007231 (2018)
Substitutions that disrupt pre-mRNA splicing are a common cause of genetic disease. On average, 13.4% of all hereditary disease alleles are classified as splicing mutations mapping to the canonical 5' and 3' splice sites. However, splicing mutations
Externí odkaz:
https://doaj.org/article/9045e7911a7344f29ae0d2cd685a1647
Autor:
Chaorui Duan, Truman Mooney, Luke Buerer, Cory Bowers, Stephen Rong, Seong Won Kim, Alger M. Fredericks, Sean F. Monaghan, William G. Fairbrother
Publikováno v:
Genome Biology, Vol 25, Iss 1, Pp 1-18 (2024)
Abstract Background The removal of introns occurs through the splicing of a 5′ splice site (5′ss) with a 3′ splice site (3′ss). These two elements are recognized by distinct components of the spliceosome. However, introns in higher eukaryotes
Externí odkaz:
https://doaj.org/article/6f2d53f327de41ca8b4d2eea6922bcd8
Autor:
Navneet Singh, Carsten Eickhoff, Augusto Garcia-Agundez, Paul Bertone, Sunita S. Paudel, Dhananjay T. Tambe, Leslie A. Litzky, Katherine Cox-Flaherty, James R. Klinger, Sean F. Monaghan, Christopher J. Mullin, Mandy Pereira, Thomas Walsh, Mary Whittenhall, Troy Stevens, Elizabeth O. Harrington, Corey E. Ventetuolo
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-15 (2023)
Abstract Pulmonary arterial hypertension (PAH) is characterized by endothelial cell (EC) dysfunction. There are no data from living patients to inform whether differential gene expression of pulmonary artery ECs (PAECs) can discern disease subtypes,
Externí odkaz:
https://doaj.org/article/fe02a15d8bc348fbaf794a7a71a2d29c
Autor:
Alger M. Fredericks, Maximilian S. Jentzsch, William G. Cioffi, Maya Cohen, William G. Fairbrother, Shivam J. Gandhi, Elizabeth O. Harrington, Gerard J. Nau, Jonathan S. Reichner, Corey E. Ventetuolo, Mitchell M. Levy, Alfred Ayala, Sean F. Monaghan
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-10 (2022)
Abstract COVID-19 has impacted millions of patients across the world. Molecular testing occurring now identifies the presence of the virus at the sampling site: nasopharynx, nares, or oral cavity. RNA sequencing has the potential to establish both th
Externí odkaz:
https://doaj.org/article/1ccc936206f04b79ba48126968de0b36
Autor:
Brandon E. Armstead, Chung Sunny Lee, Yaping Chen, Runping Zhao, Chun-Shiang Chung, Alger M. Fredericks, Sean F. Monaghan, Alfred Ayala
Publikováno v:
Frontiers in Medicine, Vol 10 (2023)
IntroductionAcute lung injury (ALI)/acute respiratory distress syndrome (ARDS) is a commonly occurring sequelae of traumatic injury resulting from indirect insults like hypovolemic shock and/or extrapulmonary sepsis. The high lethality rate associate
Externí odkaz:
https://doaj.org/article/7fece90e9ecb4d859d4993a667f6ee9f
Autor:
Alger M. Fredericks, Kyle W. East, Yuanjun Shi, Jinchan Liu, Federica Maschietto, Alfred Ayala, William G. Cioffi, Maya Cohen, William G. Fairbrother, Craig T. Lefort, Gerard J. Nau, Mitchell M. Levy, Jimin Wang, Victor S. Batista, George P. Lisi, Sean F. Monaghan
Publikováno v:
Frontiers in Molecular Biosciences, Vol 9 (2022)
Variants of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) continue to cause disease and impair the effectiveness of treatments. The therapeutic potential of convergent neutralizing antibodies (NAbs) from fully recovered patients has be
Externí odkaz:
https://doaj.org/article/4d572fd4d5154c16ba5a156cd43dae53
Autor:
Maya Cohen, Sean F. Monaghan
Publikováno v:
Physiological Reports, Vol 9, Iss 6, Pp n/a-n/a (2021)
Externí odkaz:
https://doaj.org/article/7acdee6dd36349a6a221228b025348ed
Autor:
Sean F. Monaghan, Chun-Shiang Chung, Yaping Chen, Joanne Lomas-Neira, William G. Fairbrother, Daithi S. Heffernan, William G. Cioffi, Alfred Ayala
Publikováno v:
Journal of Translational Medicine, Vol 14, Iss 1, Pp 1-9 (2016)
Abstract Background Acute respiratory distress syndrome (ARDS) remains a common organ dysfunction in the critically ill patient. Mechanisms for its development have focused on immune mediated causes, aspects of our understanding are not complete, and
Externí odkaz:
https://doaj.org/article/8a973265c5124adf9eb6c8b74e1e4442
Publikováno v:
Expert Opin Ther Targets
INTRODUCTION: Sepsis is characterized by a dysregulated host response to infection. Sepsis-associated morbidity/mortality demands concerted research efforts toward therapeutic interventions which are reliable, broadly effective, and etiologically bas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::feb1d5868f0443644f97ed8e8f92c8fb
https://doi.org/10.1080/14728222.2021.1897107
https://doi.org/10.1080/14728222.2021.1897107
Autor:
Sean F. Monaghan, Brett Murray, Neil Jikaria, Thomas Martin, Charles A. Adams, Andrew H. Stephen, Tareq Kheirbek, Stephanie N. Lueckel
Publikováno v:
Journal of Surgical Research. 258:125-131
Early administration of tranexamic acid (TXA) has been widely implemented for the treatment of presumed hyperfibrinolysis in hemorrhagic shock. We aimed to characterize the liberal use of TXA and whether unjustified administration was associated with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ab15a2f0541816ebfa7ae7b66dcb31b
https://doi.org/10.1016/j.jss.2020.08.045
https://doi.org/10.1016/j.jss.2020.08.045