Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Sean E. Doyle"'
Autor:
Sebastian A. Stifter, Nayan Bhattacharyya, Andrew J. Sawyer, Taylor A. Cootes, John Stambas, Sean E. Doyle, Lionel Feigenbaum, William E. Paul, Warwick J. Britton, Alan Sher, Carl G. Feng
Publikováno v:
Cell Reports, Vol 29, Iss 11, Pp 3539-3550.e4 (2019)
Summary: Interferons (IFN) are pleiotropic cytokines essential for defense against infection, but the identity and tissue distribution of IFN-responsive cells in vivo are poorly defined. In this study, we generate a mouse strain capable of reporting
Externí odkaz:
https://doaj.org/article/15e874e4ab5a493a85ab24a4dd2c911b
Publikováno v:
FEBS Letters. 553:403-407
Previous studies suggest that localization of tumor necrosis factor receptor (TNFR)-associated factor (TRAF) family members is important for regulating their signal transduction. During a screen for TRAF3-associated proteins that potentially alter TR
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::919668b8ce8f951d0176d93e245d99eb
https://doi.org/10.1016/s0014-5793(03)01072-x
https://doi.org/10.1016/s0014-5793(03)01072-x
Autor:
Edward Kai-Hua Chow, Kathleen Yee, Ryan M. O'Connell, Genhong Cheng, Sean E. Doyle, Sagar A. Vaidya
Publikováno v:
The Journal of Immunology. 170:3565-3571
We have recently described an IFN regulatory factor 3-mediated antiviral gene program that is induced by both Toll-like receptor (TLR)3 and TLR4 ligands. In our current study, we show that activation of IFN/viral response gene expression in primary m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c552a212549806687c7f83463ec24f8
https://doi.org/10.4049/jimmunol.170.7.3565
https://doi.org/10.4049/jimmunol.170.7.3565
Autor:
Hajir Dadgostar, Robert L. Modlin, Ren Sun, Ting-Ting Wu, M E Haberland, Govinda Rao, Sean E. Doyle, Paul W. Dempsey, Sagar A. Vaidya, Genhong Cheng, Ryan M. O'Connell
Publikováno v:
Immunity. 17:251-263
We have identified a subset of genes that is specifically induced by stimulation of TLR3 or TLR4 but not by TLR2 or TLR9. Further gene expression analyses established that upregulation of several primary response genes was dependent on NF-kappaB, com
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b41333cf17cbe91f0113da8cbdb3590
https://doi.org/10.1016/s1074-7613(02)00390-4
https://doi.org/10.1016/s1074-7613(02)00390-4
Autor:
Judith C. Gasson, Sean E. Doyle
Publikováno v:
Blood. 92:867-876
The high-affinity human granulocyte-macrophage colony-stimulating factor (GM-CSF) receptor (GMR) consists of an alpha (GMRα) and a common beta (βc) subunit. The intracellular domain of βc has been extensively characterized and has been shown to be
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8226dc76d1182a200fdeb63b4b1d9955
https://doi.org/10.1182/blood.v92.3.867
https://doi.org/10.1182/blood.v92.3.867
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 178(11)
Macrophages respond to LPS by the rapid activation of proinflammatory cytokines that serve to initiate host defense against microbial invasion. To prevent injury to the host from excess production of these cytokines, IL-10 is up-regulated to feedback
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f65d300db801e25059e886d42e4124ca
https://pubmed.ncbi.nlm.nih.gov/17513714
https://pubmed.ncbi.nlm.nih.gov/17513714
Autor:
Genhong Cheng, Soh Yamazaki, Sean E. Doyle, Gagik Oganesyan, Paul W. Dempsey, Jeannie Q. He, Brian Zarnegar, Supriya K. Saha
Publikováno v:
The Journal of Experimental Medicine
Proper activation of nuclear factor (NF)-kappaB transcription factors is critical in regulating fundamental biological processes such as cell survival and proliferation, as well as in inflammatory and immune responses. Recently, the NF-kappaB signali
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::240310fdf158e731ca427dc0a1cb5898
https://pubmed.ncbi.nlm.nih.gov/17015635
https://pubmed.ncbi.nlm.nih.gov/17015635
Autor:
Robert L. Modlin, Shinobu Suzuki, Gustavo A. Miranda, Sagar A. Vaidya, Genhong Cheng, Timothy F. Lane, Nobutaka Suzuki, Sean E. Doyle, Philip T. Liu, Wen Chen Yeh, Ryan M. O'Connell, Edward Kai-Hua Chow
Publikováno v:
The Journal of experimental medicine, vol 199, iss 1
The Journal of Experimental Medicine
The Journal of Experimental Medicine
Toll-like receptor (TLR) signaling and phagocytosis are hallmarks of macrophage-mediated innate immune responses to bacterial infection. However, the relationship between these two processes is not well established. Our data indicate that TLR ligands
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ea186269f9a3cbea8903faa0aa978f3
https://escholarship.org/uc/item/1v9026g1
https://escholarship.org/uc/item/1v9026g1
Publikováno v:
Cytokinegrowth factor reviews. 14(3-4)
Members of the TNF receptor superfamily play pivotal roles in numerous biological events in metazoan organisms. Ligand-mediated trimerization by corresponding homo- or heterotrimeric ligands, the TNF family ligands, causes recruitment of several intr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::757e1ebf993965e1f6995734f84ad28d
https://pubmed.ncbi.nlm.nih.gov/12787559
https://pubmed.ncbi.nlm.nih.gov/12787559