Zobrazeno 1 - 10 of 89 pro vyhledávání: '"Sean E. Connolly"'
1
Akademický článek
The trajectory of clinical responses in patients with early rheumatoid arthritis who achieve sustained remission in response to abatacept: subanalysis of AVERT-2, a randomized phase IIIb study
Autor: Paul Emery, Yoshiya Tanaka, Vivian P. Bykerk, Clifton O. Bingham, Thomas W. J. Huizinga, Gustavo Citera, Kuan-Hsiang Gary Huang, Chun Wu, Sean E. Connolly, Yedid Elbez, Robert Wong, Karissa Lozenski, Roy Fleischmann
Publikováno v: Arthritis Research & Therapy, Vol 25, Iss 1, Pp 1-13 (2023)
Abstract Background AVERT-2 (a phase IIIb, two-stage study) evaluated abatacept + methotrexate versus methotrexate alone, in methotrexate-naive, anti-citrullinated protein antibody-positive patients with early (≤ 6 months), active RA. This subanaly
Externí odkaz: https://doaj.org/article/6d0a8a1b51f94829ba8345f63f12219d
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2
Akademický článek
Sustained Remission and Outcomes with Abatacept plus Methotrexate Following Stepwise Dose De-escalation in Patients with Early Rheumatoid Arthritis
Autor: Paul Emery, Yoshiya Tanaka, Vivian P. Bykerk, Thomas W. J. Huizinga, Gustavo Citera, Clifton O. Bingham, Subhashis Banerjee, Benjamin P. Soule, Marleen Nys, Sean E. Connolly, Karissa L. Lozenski, Joe Zhuo, Robert Wong, Kuan-Hsiang Gary Huang, Roy Fleischmann
Publikováno v: Rheumatology and Therapy, Vol 10, Iss 3, Pp 707-727 (2023)
Abstract Introduction One target of rheumatoid arthritis (RA) treatment is to achieve early sustained remission; over the long term, patients in sustained remission have less structural joint damage and physical disability. We evaluated Simplified Di
Externí odkaz: https://doaj.org/article/031a80a1de6645ab8805525b4951051a
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3
Akademický článek
Supplementing Claims Data with Electronic Medical Records to Improve Estimation and Classification of Rheumatoid Arthritis Disease Activity: A Machine Learning Approach
Autor: Candace H. Feldman, Kazuki Yoshida, Chang Xu, Michelle L. Frits, Nancy A. Shadick, Michael E. Weinblatt, Sean E. Connolly, Evo Alemao, Daniel H. Solomon
Publikováno v: ACR Open Rheumatology, Vol 1, Iss 9, Pp 552-559 (2019)
Objective Previous attempts to estimate rheumatoid arthritis (RA) disease activity using claims data only did not yield high performance. We aimed to assess whether supplementing claims data with readily available electronic medical record (EMR) data
Externí odkaz: https://doaj.org/article/59c0337c41b74384b59f717579281585
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4
Akademický článek
Comparative Effectiveness of Abatacept Versus Tumor Necrosis Factor Inhibitors in Patients with Rheumatoid Arthritis Who Are Anti-CCP Positive in the United States Corrona Registry
Autor: Leslie R. Harrold, Heather J. Litman, Sean E. Connolly, Evo Alemao, Sheila Kelly, Sabrina Rebello, Winnie Hua, Joel M. Kremer
Publikováno v: Rheumatology and Therapy, Vol 6, Iss 2, Pp 217-230 (2019)
Abstract Introduction Anti-citrullinated protein antibodies (ACPAs) are highly specific serological biomarkers that are indicative of a poor prognosis in patients with rheumatoid arthritis (RA). The effectiveness of biologic disease-modifying antirhe
Externí odkaz: https://doaj.org/article/812cba2a5c4548318fedf2a8c36e6960
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5
Carbonyl Posttranslational Modification Associated With Early-Onset Type 1 Diabetes Autoimmunity
Autor: Mei-Ling Yang, Sean E. Connolly, Renelle J. Gee, TuKiet T. Lam, Jean Kanyo, Jian Peng, Perrin Guyer, Farooq Syed, Hubert M. Tse, Steven G. Clarke, Catherine F. Clarke, Eddie A. James, Cate Speake, Carmella Evans-Molina, Peter Arvan, Kevan C. Herold, Li Wen, Mark J. Mamula
Publikováno v: Diabetes. 71:1979-1993
Inflammation and oxidative stress in pancreatic islets amplify the appearance of various posttranslational modifications to self-proteins. In this study, we identified a select group of carbonylated islet proteins arising before the onset of hypergly
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a67a360622f1aba1f9c3f3e1caa19f49
https://doi.org/10.2337/db21-0989
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7
Differential Changes in ACPA Fine Specificity and Gene Expression in a Randomized Trial of Abatacept and Adalimumab in Rheumatoid Arthritis
Autor: Omar Jabado, Michael A. Maldonado, Michael Schiff, Michael E. Weinblatt, Roy Fleischmann, William H. Robinson, Aiqing He, Vishal Patel, Alex Greenfield, Jasmine Saini, David Galbraith, Sean E. Connolly
Publikováno v: Rheumatology and Therapy. 9:391-409
The biologics abatacept and adalimumab have different mechanisms of action (MoAs). We analyzed data from patients with rheumatoid arthritis treated in AMPLE (NCT00929864) to explore the pharmacodynamic effects of abatacept or adalimumab on anti-citru
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60d1f01993c2ba8d54d343345db6ed80
https://doi.org/10.1007/s40744-021-00404-x
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10
ACPA-negative and ACPA-positive RA patients achieving disease resolution demonstrate distinct patterns of MRI-detected joint-inflammation
Autor: Marloes Verstappen, Xanthe M E Matthijssen, Sean E Connolly, Michael A Maldonado, Tom W J Huizinga, Annette H M van der Helm-van Mil
Publikováno v: Rheumatology, 62(1), 124-134. OXFORD UNIV PRESS
Objectives Although sustained DMARD-free remission (SDFR; sustained absence of clinical-synovitis after DMARD-discontinuation) is increasingly achievable in RA, prevalence differs between ACPA-negative (40%) and ACPA-positive RA (5–10%). Additional
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2141cefce39eba8976be589b72df9ee3
https://hdl.handle.net/1887/3458788
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