Zobrazeno 1 - 10
of 205
pro vyhledávání: '"Sean E Egan"'
Publikováno v:
EMBO Molecular Medicine, Vol 13, Iss 3, Pp n/a-n/a (2021)
Invasive lobular carcinoma (ILC) of the breast is a very common disease. Despite its prevalence, these tumors are relatively understudied. One reason for this is a relative lack of models for ILC. This challenge was addressed by Brisken and colleague
Externí odkaz:
https://doaj.org/article/01c2ba6db773419681ce36782f3d654e
Autor:
Jeff C Liu, Veronique Voisin, Sharon Wang, Dong‐Yu Wang, Robert A Jones, Alessandro Datti, David Uehling, Rima Al‐awar, Sean E Egan, Gary D Bader, Ming Tsao, Tak W Mak, Eldad Zacksenhaus
Publikováno v:
EMBO Molecular Medicine, Vol 6, Iss 12, Pp 1542-1560 (2014)
Abstract The tumor suppressors Pten and p53 are frequently lost in breast cancer, yet the consequences of their combined inactivation are poorly understood. Here, we show that mammary‐specific deletion of Pten via WAP‐Cre, which targets alveolar
Externí odkaz:
https://doaj.org/article/1740747192ac46058246e34663ff888d
Autor:
Tyler J W Robinson, Jeff C Liu, Frederick Vizeacoumar, Thomas Sun, Neil Maclean, Sean E Egan, Aaron D Schimmer, Alessandro Datti, Eldad Zacksenhaus
Publikováno v:
PLoS ONE, Vol 8, Iss 11, p e78641 (2013)
Triple negative breast cancer (TNBC) includes basal-like and claudin-low subtypes for which only chemotherapy and radiation therapy are currently available. The retinoblastoma (RB1) tumor suppressor is frequently lost in human TNBC. Knockdown of RB1
Externí odkaz:
https://doaj.org/article/cf5d10504ba3454fa43bda899d685d0f
Autor:
Sara Suliman, Joanne Tan, Keli Xu, Philaretos C Kousis, Paul E Kowalski, Greg Chang, Sean E Egan, Cynthia Guidos
Publikováno v:
PLoS ONE, Vol 6, Iss 9, p e24937 (2011)
Notch1 (N1) signaling induced by intrathymic Delta-like (DL) ligands is required for T cell lineage commitment as well as self-renewal during "β-selection" of TCRβ⁺CD4⁻CD8⁻ double negative 3 (DN3) T cell progenitors. However, over-expression
Externí odkaz:
https://doaj.org/article/48adf2dfd9d14d038d7d8159b68c0821
Autor:
Daniel Schramek, Geoffrey M. Wahl, Miguel Angel Pujana, Erik S. Knudsen, Agnieszka K. Witkiewicz, Michael D. Wilson, Hartland W. Jackson, Jeffrey L. Wrana, Therese Sørlie, David W. Cescon, Sean E. Egan, Gary D. Bader, Rod Bremner, Sampath K. Loganathan, Seda Barutcu, Thomas Nguyen, Jeff C. Liu, Masahiro Narimatsu, Daniel Trcka, Katelyn J. Kozma, Robin H. Oh, YiQing Lü, Andrew Elia, Sana Alvi, Ricky Tsai, Somaieh Afiuni-Zadeh, Samah El Ghamrasni, Helga Bergholtz, Ahmad Malik, Katie Teng, Roderic Espin, Liis Uuskula-Reimand, Minggao Liang, Zhibo Ma, Khalid N. Al-Zahrani, Ellen Langille
Systematically investigating the scores of genes mutated in cancer and discerning disease drivers from inconsequential bystanders is a prerequisite for precision medicine but remains challenging. Here, we developed a somatic CRISPR/Cas9 mutagenesis s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f3e88720028d1c1acd19d4e081944a9
https://doi.org/10.1158/2159-8290.c.6549708.v1
https://doi.org/10.1158/2159-8290.c.6549708.v1
Autor:
Daniel Schramek, Geoffrey M. Wahl, Miguel Angel Pujana, Erik S. Knudsen, Agnieszka K. Witkiewicz, Michael D. Wilson, Hartland W. Jackson, Jeffrey L. Wrana, Therese Sørlie, David W. Cescon, Sean E. Egan, Gary D. Bader, Rod Bremner, Sampath K. Loganathan, Seda Barutcu, Thomas Nguyen, Jeff C. Liu, Masahiro Narimatsu, Daniel Trcka, Katelyn J. Kozma, Robin H. Oh, YiQing Lü, Andrew Elia, Sana Alvi, Ricky Tsai, Somaieh Afiuni-Zadeh, Samah El Ghamrasni, Helga Bergholtz, Ahmad Malik, Katie Teng, Roderic Espin, Liis Uuskula-Reimand, Minggao Liang, Zhibo Ma, Khalid N. Al-Zahrani, Ellen Langille
Supplementary Data from Loss of Epigenetic Regulation Disrupts Lineage Integrity, Induces Aberrant Alveogenesis, and Promotes Breast Cancer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a0b4da81cbb00416f796f44e9fdd2b9
https://doi.org/10.1158/2159-8290.22541622.v1
https://doi.org/10.1158/2159-8290.22541622.v1
Autor:
Sean E. Egan, Pingzhao Hu, Eldad Zacksenhaus, James R. Woodgett, Susan J. Done, Sergei B. Koralov, Timothy F. Lane, Xue Mei, Laura Weiss, Divya R. Santhanam, Lauren A. Beck, Christine E.B. Jo, Ruth G. Wong, Amanda J. Loch, Jeff C. Liu, Jessica R. Adams, Katherine L. Wright
Supplementary Table 1. Kaplan-Meier survival statistics for control and experimental mice: This table presents results of analysis on tumor assays.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08cb222a500827bc9535012df88ffbd3
https://doi.org/10.1158/0008-5472.22411086
https://doi.org/10.1158/0008-5472.22411086
Autor:
Sean E. Egan, Pingzhao Hu, Eldad Zacksenhaus, James R. Woodgett, Susan J. Done, Sergei B. Koralov, Timothy F. Lane, Xue Mei, Laura Weiss, Divya R. Santhanam, Lauren A. Beck, Christine E.B. Jo, Ruth G. Wong, Amanda J. Loch, Jeff C. Liu, Jessica R. Adams, Katherine L. Wright
Supplementary Figure Legends 1-5
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::afff50d23d4366be0ad032cdd227051c
https://doi.org/10.1158/0008-5472.22411095.v1
https://doi.org/10.1158/0008-5472.22411095.v1
Autor:
Sean E. Egan, Pingzhao Hu, Eldad Zacksenhaus, James R. Woodgett, Susan J. Done, Sergei B. Koralov, Timothy F. Lane, Xue Mei, Laura Weiss, Divya R. Santhanam, Lauren A. Beck, Christine E.B. Jo, Ruth G. Wong, Amanda J. Loch, Jeff C. Liu, Jessica R. Adams, Katherine L. Wright
Supplementary Figures 1-5. Supplementary Fig. 1. Kaplan-Meier overall survival curves and cause of death data for control and experimental female mice. Supplementary Fig. 2. Mammary pathology analysis and estrogen receptor α staining for experimenta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65b0e1778b5234d78b7628406da9c16a
https://doi.org/10.1158/0008-5472.22411092
https://doi.org/10.1158/0008-5472.22411092
Autor:
Eldad Zacksenhaus, Jason Moffat, Rima Al-awar, Sean E. Egan, Robert Rottapel, Nathan F. Schachter, Zhe Jiang, Troy Ketela, Babu Joseph, Ahmed Aman, David Uehling, Philip E.D. Chung, Jeff C. Liu, Tao Deng
PDF file - 753KB, Supplementary Figure S5 shows representative images of HCC1954 and SKBR3 HER2+ BC cells transduced with indicated lenti-shRNA against human Tbk1 or lenti-GFP.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12f251a82557d33c7c6ffe727d92dbac
https://doi.org/10.1158/0008-5472.22401191.v1
https://doi.org/10.1158/0008-5472.22401191.v1