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pro vyhledávání: '"Sean De la O"'
Publikováno v:
Molecular Metabolism, Vol 73, Iss , Pp 101735- (2023)
Numerous studies have characterized the existence of cell subtypes, along with their corresponding transcriptional profiles, within the developing mouse pancreas. The upstream mechanisms that initiate and maintain gene expression programs across cell
Externí odkaz:
https://doaj.org/article/68b654b2bcc940998699d2375d4f1cb9
Autor:
Sophie Patzek, Zhe Liu, Sean de la O, Sean Chang, Lauren E. Byrnes, Xiuqin Zhang, David M. Ornitz, Julie B. Sneddon
Publikováno v:
iScience, Vol 26, Iss 4, Pp 106500- (2023)
Summary: Pancreatic development requires spatially and temporally controlled expression of growth factors derived from mesenchyme. Here, we report that in mice the secreted factor Fgf9 is expressed principally by mesenchyme and then mesothelium durin
Externí odkaz:
https://doaj.org/article/bd0d92840287409786057b307a72e385
Autor:
Haley R. Barlow, Neha Ahuja, Tyler Bierschenk, Yadanar Htike, Luke Fassetta, D. Berfin Azizoglu, Juan Flores, Nan Gao, Sean De la O, Julie B. Sneddon, Denise K. Marciano, Ondine Cleaver
Publikováno v:
Developmental Biology. 499:59-74
Numerous studies have characterized the existence of cell subtypes, along with their corresponding transcriptional profiles, within the developing mouse pancreas. The upstream mechanisms that initiate and maintain gene expression programs across cell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a8d8e94beff185f5a7ade29aee9a72bd
https://doi.org/10.1101/2022.10.01.510484
https://doi.org/10.1101/2022.10.01.510484
Akademický článek
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Publikováno v:
Diabetes. 68
Pancreatic organogenesis is a complex, multistep process whereby multiple cell types must migrate, proliferate, and differentiate in a strict spatiotemporal manner to ultimately form the complete organ. Although pancreatic epithelial organogenesis is
Autor:
Michael C. Bassik, G. B. Taylor, Jie Ding, Jose A. Seoane, Calvin J. Kuo, Zhicheng Ma, Sean de la O, Junjie Zhu, Ameen A. Salahudeen, Kyuho Han, David W. Morgens, Navika D. Shukla, Daniel J. Hart, Kanako Yuki, Christina Curtis
Publikováno v:
Journal of Clinical Oncology. 36:46-46
46 Background: Esophageal squamous cell carcinomas remains a particularly intractable disease due to limited therapeutic options as well as a lack of targeted therapies. The genetic landscape of esophageal squamous cell carcinoma is varied, but a com
Autor:
Chad Sanada, Naveen Ramalingam, Gerald Quon, Melanie Triboulet, Calvin J. Kuo, Ameen A. Salahudeen, Sean de la O, Corinne Renier, Elodie Sollier-Christen, George W. Sledge, Shoshana Levy, Cassandra Greene, Jay A. A. West, Tracy Lu, Vishnu C. Ramani, Lukasz Szpankowski, Ranjani Rajapaksa, Rakhi Gupta, Stefanie S. Jeffrey, Anne A. Leyrat
Publikováno v:
Cancer Research. 77:1847-1847
We report an in-depth characterization of patient-derived orthotopic xenograft (PDOX) models of triple-negative breast cancer (TNBC) regarding their molecular profile at the single cell level, tumor heterogeneity, 3D organoid generation, and ability
Autor:
Daniel J. Hart, Michael C. Bassik, Calvin J. Kuo, Kyuho Han, David W. Morgens, Ameen A. Salahudeen, Sean de la O
Publikováno v:
Journal of Clinical Oncology. 35:77-77
77 Background: Genome scale sequencing efforts have identified chromosomal deletions and non-synonymous mutations as putative drivers of gastro-intestinal cancer. There is a need to rapidly validate these drivers in robust models. The culture of prim