Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Sean D. Monahan"'
Autor:
Michael E. Houston, Jean-Rene E. Ella-Menye, Anna Galperin, Matt Waldheim, Teri Blevins, Mary G. Prieve, Eric Bell, Sean D. Monahan, Amber Paschal, Pierrot Harvie, Allen Li, Debashish Roy
Publikováno v:
Molecular Therapy. 26:801-813
We describe a novel, two-nanoparticle mRNA delivery system and show that it is highly effective as a means of intracellular enzyme replacement therapy (i-ERT) using a murine model of ornithine transcarbamylase deficiency (OTCD). Our Hybrid mRNA Techn
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ed8529dd870758e7cdf6db80d17d3c4
https://doi.org/10.1016/j.ymthe.2017.12.024
https://doi.org/10.1016/j.ymthe.2017.12.024
Publikováno v:
Drug Discovery Today. 19:1855-1870
Insufficient drug uptake by solid tumors remains the major problem for systemic chemotherapy. Many studies have demonstrated anticancer drug effects to be dose-dependent, although dose-escalation studies have resulted in limited survival benefit with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cbfa520c5ae62577479a139d634189c1
https://doi.org/10.1016/j.drudis.2014.08.009
https://doi.org/10.1016/j.drudis.2014.08.009
Autor:
Sean D. Monahan, Jon A. Wolff, Hans Herweijer, Paul M. Slattum, Zane C. Neal, Vladimir M. Subbotin, Vladimir G. Budker
Publikováno v:
Chemistry & Biology. 14:1065-1077
SummaryWe have investigated a rapidly reversible hydrophobization of therapeutic agents for improving first-pass uptake in locoregional drug therapy. This approach involves the attachment of a hydrophobic moiety to the drug by highly labile chemical
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7f14d78540b4a030b3ff495843196f3
https://doi.org/10.1016/j.chembiol.2007.08.011
https://doi.org/10.1016/j.chembiol.2007.08.011
Autor:
Jason Klein, Darren H. Wakefield, and Alex V. Sokoloff, Sean D. Monahan, Jon A. Wolff, David B. Rozema, Lori Higgs, James J. Ludtke, David L. Lewis, So C. Wong
Publikováno v:
Molecular Pharmaceutics. 3:386-397
A critical step for liver-directed gene therapy is the selective targeting of nucleic acids to hepatocytes. We have previously discovered that the proximal half of the T7 phage tail fiber protein (p17) targeted intact T7 phage and recombinant protein
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98eda459ef51a3ee01e2580ebf63745a
https://doi.org/10.1021/mp050108r
https://doi.org/10.1021/mp050108r
Autor:
Debashish Roy, Matt Waldheim, Allen Li, Pierrot Harvie, Sean D. Monahan, Amber Paschal, Gordon Brandt, Michael E. Houston, Jean-Rene Ella Menye, Eric Bell, Teri Blevins, Mary G. Prieve, Anna Galperin
Publikováno v:
Molecular Genetics and Metabolism. 120:S31
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::92e9eff305471abc5a3128cffd7f476f
https://doi.org/10.1016/j.ymgme.2016.11.050
https://doi.org/10.1016/j.ymgme.2016.11.050
Autor:
Edwin Vedejs, Sean D. Monahan
Publikováno v:
The Journal of Organic Chemistry. 62:4763-4769
Azomethine ylide generation from the oxazolium salt 22 and PhSiH3/CsF affords complex products derived from the initial cycloadduct 23 via three competing pathways. Colorless intermediates 24−27 have been detected, and their oxidation products 10,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::48f5a8968faa926cde4718c4f98b75c5
https://doi.org/10.1021/jo9702195
https://doi.org/10.1021/jo9702195
Autor:
Jean-Rene Ella Menye, Amber Paschal, Mary G. Prieve, Sean D. Monahan, Maher Qabar, Michael E. Houston, Allen Li, Alex Baturevych, Pierrot Harvie, Eric Bell, Matt Waldheim, Teri Blevins, Anna Galperin, Debashish Roy
Publikováno v:
Molecular Therapy. 24:S66
Messenger RNA (mRNA) is a promising alternative in both the viral and non-viral DNA-based gene delivery fields. Current viral vectors for gene therapy are associated with serious safety concerns and nonviral vectors are limited by low gene transfer e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e7116dbc72e6ccce376fb78c89af74cb
https://doi.org/10.1016/s1525-0016(16)32979-3
https://doi.org/10.1016/s1525-0016(16)32979-3
Autor:
Edwin Vedejs, Sean D. Monahan
Publikováno v:
ChemInform. 27
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1173d3d6f5c3da5eb3fc5899229d4138
https://doi.org/10.1002/chin.199651115
https://doi.org/10.1002/chin.199651115
Autor:
Sean D. Monahan, Edwin Vedejs
Publikováno v:
ChemInform. 28
Azomethine ylide generation from the oxazolium salt 22 and PhSiH3/CsF affords complex products derived from the initial cycloadduct 23 via three competing pathways. Colorless intermediates 24−27 have been detected, and their oxidation products 10,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::652f63a72aa7173bb11e0db9982c12d1
https://doi.org/10.1002/chin.199749142
https://doi.org/10.1002/chin.199749142
Autor:
So C. Wong, Guofeng Zhang, James E. Hagstrom, Jon A. Wolff, Vladimir G. Budker, David L. Lewis, Tatiana Budker, Sean D. Monahan, Magdolna G. Sebestyén, Vladimir M. Subbotin
Publikováno v:
The journal of gene medicine. 8(7)
Background The hydrodynamic tail vein (HTV) injection of naked plasmid DNA is a simple yet effective in vivo gene delivery method into hepatocytes. It is increasingly being used as a research tool to elucidate mechanisms of gene expression and the ro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3aa8f15935375e9906ccf4122a053254
https://pubmed.ncbi.nlm.nih.gov/16724360
https://pubmed.ncbi.nlm.nih.gov/16724360