Výsledky vyhledávání - "Sean D. Hurley"

Interleaved Carbon Minibeams: An Experimental Radiosurgery Method With Clinical Potential

Autor: Giovanna R. Fois, Nicolle R. Desnoyers, John A. Olschowka, Ruiliang Wang, Allen G. Meek, Adam Rusek, Dardo Tomasi, I. Dioszegi, Hedok Lee, F. Avraham Dilmanian, Bari Dane, Jane Y. Park, Patricia K. Coyle, Sean D. Hurley, M. Kerry O'Banion

Publikováno v: International Journal of Radiation Oncology*Biology*Physics. 84:514-519

Purpose To evaluate the efficacy of "interleaved carbon minibeams" for ablating a 6.5-mm target in a rabbit brain with little damage to the surrounding brain. The method is based on the well-established tissue-sparing effect of arrays of thin planes

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57578eaa2031411810d55dfeaeb915e4
https://doi.org/10.1016/j.ijrobp.2011.12.025

Zobrazit plný text záznamu

Cytosolic prostaglandin E2 synthase (cPGES) expression is decreased in discrete cortical regions in psychiatric disease

Autor: Mary E. Maida, Sean D. Hurley, Jo Anna Daeschner, Amy H. Moore, M. Kerry O'Banion

Publikováno v: Brain Research. 1103:164-172

The number of adults in the US affected by bipolar disorder, depression, or schizophrenia is approaching 15 million. Despite decades of research, etiologies of these illnesses remain elusive. Theories of aberrant brain morphology, neurotransmission,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::705a13d72e300544fc798de6df5177d9
https://doi.org/10.1016/j.brainres.2006.05.048

Zobrazit plný text záznamu

Acute morphine exposure potentiates the development of HSV-1-induced encephalitis

Autor: Jan A. Moynihan, Amy M. Martin, James R. Walton, Sean D. Hurley, Patricia A. Sheridan, John A. Olschowka, Daniel T. Lioy

Publikováno v: Journal of Neuroimmunology. 172:9-17

A devastating consequence of HSV-1 infection is development of HSV-1-induced encephalitis (HSVE). While only a minority of individuals infected with HSV-1 experiences HSVE, clearly defined variables that consistently predict development of the diseas

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6fd30728154a351f5a45b542e3deda62
https://doi.org/10.1016/j.jneuroim.2005.10.007

Zobrazit plný text záznamu

Infection with an Endemic Human Herpesvirus Disrupts Critical Glial Precursor Cell Properties

Autor: Mikhail Roshal, David J. Mock, Jeffrey V Baker, Joerg Dietrich, Benjamin M. Blumberg, Margot Mayer-Pröschel, Sean D. Hurley

Publikováno v: The Journal of Neuroscience. 24:4875-4883

Human herpesvirus 6 (HHV-6), a common resident virus of the human CNS, has been implicated in both acute and chronic inflammatory–demyelinating diseases. Although HHV-6 persists within the human CNS and has been described to infect mature oligodend

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c45b294a2d29bb5d7fb56c9f46614e49
https://doi.org/10.1523/jneurosci.5584-03.2004

Zobrazit plný text záznamu

Helper-free HSV-1 amplicons elicit a markedly less robust innate immune response in the CNS

Autor: William J. Bowers, Sean D. Hurley, Michael A. Mastrangelo, John A. Olschowka, Howard J. Federoff

Publikováno v: Molecular Therapy. 7:218-227

The development and implementation of direct gene transfer technologies for the study and treatment of chronic CNS disorders inherently requires consideration of vector safety. Virus-based vectors represent the most efficient modalities but harbor th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4fee5e54179d930f8bafd8dbc5a71279
https://doi.org/10.1016/s1525-0016(02)00036-9

Zobrazit plný text záznamu

Cyclooxygenase Inhibition as a Strategy to Ameliorate Brain Injury

Autor: M. Kerry O'Banion, Sean D. Hurley, John A. Olschowka

Publikováno v: Journal of Neurotrauma. 19:1-15

Cyclooxygenase (COX) is the obligate, rate-limiting enzyme for the conversion of arachidonic acid into prostaglandins. Two COX enzymes have been identified: a constitutively expressed COX-1 and an inducible, highly regulated COX-2. Widely used to tre

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef69fb2410d827515deee0cb826f2d95
https://doi.org/10.1089/089771502753460196

Zobrazit plný text záznamu

Comparative evaluation of cytokine profiles and reactive gliosis supports a critical role for interleukin-6 in neuron-glia signaling during regeneration

Autor: Sean D. Hurley, Wolfgang J. Streit, Susan L. Semple-Rowland, Tanya S. McGraw

Publikováno v: Journal of Neuroscience Research. 61:10-20

Using reverse transcription polymerase chain reaction (RT-PCR), we have studied the temporal expression of interleukin-1beta (IL-1beta), interleukin-6 (IL-6), transforming growth factor-beta 1 (TGF-beta 1), and tumor necrosis factor-alpha (TNF-alpha)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ccac79c3248d80bbae284c11f71ecefd
https://doi.org/10.1002/1097-4547(20000701)61:1<10::aid-jnr2>3.0.co

Zobrazit plný text záznamu

Cytokine transcripts expressed by microglia in vitro are not expressed by ameboid microglia of the developing rat central nervous system

Autor: Susan L. Semple-Rowland, Sean D. Hurley, Wolfgang J. Streit, Sharon A. Walter

Publikováno v: Glia. 25:304-309

Because of morphological similarities between ameboid microglia in the developing central nervous system (CNS), brain macrophages in the injured CNS, and cultured microglia in vitro, it is thought that these cell types are functionally equivalent. To

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::522c4f6ea4a66729b9e26371e3455025
https://doi.org/10.1002/(sici)1098-1136(19990201)25:3<304::aid-glia10>3.0.co

Zobrazit plný text záznamu

Cytokine mRNA Profiles in Contused Spinal Cord and Axotomized Facial Nucleus Suggest a Beneficial Role for Inflammation and Gliosis

Autor: Sean D. Hurley, Phillip G. Popovich, Rehae Miller, Susan L. Semple-Rowland, Bradford T. Stokes, Wolfgang J. Streit

Publikováno v: Experimental Neurology. 152:74-87

We have studied temporal mRNA expression patterns for interleukin-1beta (IL-1beta), tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), macrophage colony stimulating factor (M-CSF), and transforming growth factor-beta1 (TGF-beta1) in two r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87604995ffc56123f3b55be770829326
https://doi.org/10.1006/exnr.1998.6835

Zobrazit plný text záznamu

X-ray microbeam irradiation of the contusion-injured rat spinal cord temporarily improves hind-limb function

Autor: F. Avraham Dilmanian, Arthur L. Jenkins, Saffa Ahmad, Catherine R. Messina, Allen G. Meek, LeeAnn Trojanczyk, Stanislaw Sobotka, Nicolle R. Desnoyers, Patricia K. Coyle, Marjorie Morales, John A. Olschowka, Sean D. Hurley, Neda Shahrabi, Giovanna R. Fois, Zhong Zhong, Jane Y. Park, M. Kerry O'Banion

Publikováno v: Radiation research. 179(1)

Spinal cord injury is a devastating condition with no effective treatment. The physiological processes that impede recovery include potentially detrimental immune responses and the production of reactive astrocytes. Previous work suggested that radia

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89cfe6884be8ffa6b881dda262ce946a
https://pubmed.ncbi.nlm.nih.gov/23216524

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání