Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Sean D. Geddes"'
Autor:
Faranak Vahid-Ansari, Christine Luckhart, René Hen, Valérie Turcotte-Cardin, Sean D. Geddes, Zul Merali, Jean-Claude Béïque, Mireille Daigle, Kenji F. Tanaka, Paul R. Albert, Jonathan S. James
Selective serotonin (5-HT) reuptake inhibitors (SSRIs) are first-line antidepressants but require several weeks to elicit their actions. Chronic SSRI treatment induces desensitization of 5-HT1A autoreceptors to enhance 5-HT neurotransmission. Mice (b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9a81dcb1bccd26e32f3d620336e7a63
https://europepmc.org/articles/PMC6381250/
https://europepmc.org/articles/PMC6381250/
Autor:
Saleha Assadzada, Alexandra Sokolovski, Sean D. Geddes, Samir Haj-Dahmane, Jean-Claude Béïque, David Lemelin, Richard Bergeron
Publikováno v:
Proceedings of the National Academy of Sciences. 113:5429-5434
Serotonin (5-HT) neurons located in the raphe nuclei modulate a wide range of behaviors by means of an expansive innervation pattern. In turn, the raphe receives a vast array of synaptic inputs, and a remaining challenge lies in understanding how the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74f4447aa7362c58405d658cef7ffde0
https://doi.org/10.1073/pnas.1522754113
https://doi.org/10.1073/pnas.1522754113
Autor:
Zul Merali, Mireille Daigle, Faranak Vahid-Ansari, Jean-Claude Béïque, Kenji F. Tanaka, Sean D. Geddes, Paul R. Albert, Jonathan S. James, M. Chiara Manzini, René Hen
Freud-1/Cc2d1a represses the gene transcription of serotonin-1A (5-HT1A) autoreceptors, which negatively regulate 5-HT tone. To test the role of Freud-1in vivo, we generated mice with adulthood conditional knock-out of Freud-1 in 5-HT neurons (cF1ko)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5dc9b304ac040787c3beb59246051c7b
https://europepmc.org/articles/PMC5722640/
https://europepmc.org/articles/PMC5722640/
Autor:
Faranak Vahid-Ansari, Mireille Daigle, Diane C. Lagace, Jean-Claude Béïque, Brice Le François, Tristan J. Philippe, Christine Luckhart, Sean D. Geddes, Paul R. Albert
Publikováno v:
Molecular Brain
The C (-1019) G rs6295 promoter polymorphism of the serotonin-1A (5-HT1A) receptor gene is associated with major depression in several but not all studies, suggesting that compensatory mechanisms mediate resilience. The rs6295 risk allele prevents bi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ac5d972a902bbee889123758b346e34
https://pubmed.ncbi.nlm.nih.gov/27488351
https://pubmed.ncbi.nlm.nih.gov/27488351
Autor:
Samir Haj-Dahmane, Jean-Claude Béïque, Richard Bergeron, Sean D. Geddes, Alexandra Sokolovski, Saleha Assadzada
Publikováno v:
Neuropharmacology. 95
Antidepressants, including the selective serotonin reuptake inhibitors (SSRIs), are thought to exert their clinical effects by enhancing serotonin (5-HT) transmission. However, animal studies show that the full magnitude of this enhancement is reache
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8603761bdb268bd1706828f15f83e334
https://pubmed.ncbi.nlm.nih.gov/25747603
https://pubmed.ncbi.nlm.nih.gov/25747603