Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Sean D Speese"'
Autor:
Maria D Purice, Arpita Ray, Eva Jolanda Münzel, Bernard J Pope, Daniel J Park, Sean D Speese, Mary A Logan
Publikováno v:
eLife, Vol 6 (2017)
Neural injury triggers swift responses from glia, including glial migration and phagocytic clearance of damaged neurons. The transcriptional programs governing these complex innate glial immune responses are still unclear. Here, we describe a novel i
Externí odkaz:
https://doaj.org/article/d95a75fdb09148988460fa78e711fb10
Autor:
Danielle S.K. Brasino, Sean D. Speese, Kevin Schilling, Carolyn E. Schutt, Michelle C. Barton
Publikováno v:
Advanced Science, Vol 11, Iss 35, Pp n/a-n/a (2024)
Abstract Gut microbiome composition is tied to diseases ranging from arthritis to cancer to depression. However, mechanisms of action are poorly understood, limiting development of relevant therapeutics. Organ‐on‐chip platforms, which model minim
Externí odkaz:
https://doaj.org/article/aa8ea7bcb771466fa068ae65ec76cfa8
Autor:
Katharina S. Keuenhof, Verena Kohler, Filomena Broeskamp, Dimitra Panagaki, Sean D. Speese, Sabrina Büttner, Johanna L. Höög
Publikováno v:
Nucleus, Vol 14, Iss 1 (2023)
ABSTRACTThe nuclear pore complex (NPC) has long been assumed to be the sole route across the nuclear envelope, and under normal homeostatic conditions it is indeed the main mechanism of nucleo-cytoplasmic transport. However, it has also been known th
Externí odkaz:
https://doaj.org/article/4b7bb68c77f04a0bb213452995631ac2
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
Glial engulfment declines with age, but the mechanism is unclear. Here authors show that in the Drosophilaolfactory system, glial phagocytosis of injury-induced degenerating axons decreases with age due to reduced PI3K/Draper activity, and restoring
Externí odkaz:
https://doaj.org/article/f6b672af42684873a638cdf9f9fd3158
Autor:
Bruce P. Branchaud, Sean D. Speese, Sinan Sabuncu, Emma Olson, Sarah A. Barnhill, Adem Yildirim, Corey M. Dambacher, Srivathsan V. Ranganathan, Justin S. Plaut
Publikováno v:
ACS Applied Nano Materials. 4:7800-7810
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fc59391e388a4a48d821483edeab261b
https://doi.org/10.1021/acsanm.1c01098
https://doi.org/10.1021/acsanm.1c01098
Neural injury triggers striking immune reactions from glial cells, including significant transcriptional and morphological changes, but it is unclear how these events are coordinated to mount an effective immune response. Here, we present a new varia
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c95d048759354f978f95404fc9743a5f
https://doi.org/10.1101/2021.08.13.456301
https://doi.org/10.1101/2021.08.13.456301
Publikováno v:
Cancer Research. 82:196-196
Gut microbiota are recognized as an integral part in maintaining health, with disturbances in composition linked to disease states ranging from cancer to depression. Breast cancer patient microbiome analysis has demonstrated a correlation between dys
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2458fa03d8cbf6a0d5c838eed33cae73
https://doi.org/10.1158/1538-7445.am2022-196
https://doi.org/10.1158/1538-7445.am2022-196
Autor:
Mary A, Logan, Sean D, Speese
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 2143
Axon degeneration elicits a range of immune responses from local glial cells, including striking changes in glial gene expression, morphology, and phagocytic activity. Here, we describe a detailed set of protocols to assess discrete components of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::23cdfb8749397aa21ba60afc9d92f5b3
https://pubmed.ncbi.nlm.nih.gov/32524491
https://pubmed.ncbi.nlm.nih.gov/32524491
Autor:
Sean D. Speese, Mary A. Logan
Publikováno v:
Methods in Molecular Biology ISBN: 9781071605844
Axon degeneration elicits a range of immune responses from local glial cells, including striking changes in glial gene expression, morphology, and phagocytic activity. Here, we describe a detailed set of protocols to assess discrete components of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0623e93ed01e52be0d21568890af79b1
https://doi.org/10.1007/978-1-0716-0585-1_24
https://doi.org/10.1007/978-1-0716-0585-1_24
Publikováno v:
The Journal of Neuroscience. 37:11881-11893
Pathological hallmarks of Alzheimer's disease (AD) include amyloid-β (Aβ) plaques, neurofibrillary tangles, and reactive gliosis. Glial cells offer protection against AD by engulfing extracellular Aβ peptides, but the repertoire of molecules requi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b71fc04c00a75c65aa43eb09869c3032
https://doi.org/10.1523/jneurosci.0862-17.2017
https://doi.org/10.1523/jneurosci.0862-17.2017