Zobrazeno 1 - 10
of 204
pro vyhledávání: '"Sean D Mooney"'
Publikováno v:
JMIR Formative Research, Vol 8, p e56510 (2024)
BackgroundThe environment shapes health behaviors and outcomes. Studies exploring this influence have been limited to research groups with the geographic information systems expertise required to develop built and social environment measures (eg, gro
Externí odkaz:
https://doaj.org/article/869fcacd6c7743eab5349399d128ce83
Autor:
Doyanne Darnell, Patricia A Areán, Shannon Dorsey, David C Atkins, Michael J Tanana, Tad Hirsch, Sean D Mooney, Edwin D Boudreaux, Katherine Anne Comtois
Publikováno v:
JMIR Research Protocols, Vol 10, Iss 12, p e33695 (2021)
BackgroundSuicide is the 10th leading cause of death in the United States, with >47,000 deaths in 2019. Most people who died by suicide had contact with the health care system in the year before their death. Health care provider training is a top res
Externí odkaz:
https://doaj.org/article/584eceb0e7054ed89284000eeda6eb21
Autor:
Maria-Daniela Cirnaru, Sicheng Song, Kizito-Tshitoko Tshilenge, Chuhyon Corwin, Justyna Mleczko, Carlos Galicia Aguirre, Houda Benlhabib, Jaroslav Bendl, Pasha Apontes, John Fullard, Jordi Creus-Muncunill, Azadeh Reyahi, Ali M Nik, Peter Carlsson, Panos Roussos, Sean D Mooney, Lisa M Ellerby, Michelle E Ehrlich
Publikováno v:
eLife, Vol 10 (2021)
Many diseases are linked to dysregulation of the striatum. Striatal function depends on neuronal compartmentation into striosomes and matrix. Striatal projection neurons are GABAergic medium spiny neurons (MSNs), subtyped by selective expression of r
Externí odkaz:
https://doaj.org/article/301679f6c49048c8a4afba920502c74a
Autor:
Kymberleigh A Pagel, Danny Antaki, AoJie Lian, Matthew Mort, David N Cooper, Jonathan Sebat, Lilia M Iakoucheva, Sean D Mooney, Predrag Radivojac
Publikováno v:
PLoS Computational Biology, Vol 15, Iss 6, p e1007112 (2019)
Differentiation between phenotypically neutral and disease-causing genetic variation remains an open and relevant problem. Among different types of variation, non-frameshifting insertions and deletions (indels) represent an understudied group with wi
Externí odkaz:
https://doaj.org/article/c58743cc8e6943eb9bb3d5caa0495351
Autor:
Jose Lugo-Martinez, Vikas Pejaver, Kymberleigh A Pagel, Shantanu Jain, Matthew Mort, David N Cooper, Sean D Mooney, Predrag Radivojac
Publikováno v:
PLoS Computational Biology, Vol 12, Iss 8, p e1005091 (2016)
Elucidating the precise molecular events altered by disease-causing genetic variants represents a major challenge in translational bioinformatics. To this end, many studies have investigated the structural and functional impact of amino acid substitu
Externí odkaz:
https://doaj.org/article/acea1bac0dcd44de83b76509f777fe37
Publikováno v:
PLoS Computational Biology, Vol 11, Iss 4, p e1004150 (2015)
Externí odkaz:
https://doaj.org/article/da3d31a1a68545dd8f2183ce53d79315
Autor:
John P Miller, Bridget E Yates, Ismael Al-Ramahi, Ari E Berman, Mario Sanhueza, Eugene Kim, Maria de Haro, Francesco DeGiacomo, Cameron Torcassi, Jennifer Holcomb, Juliette Gafni, Sean D Mooney, Juan Botas, Lisa M Ellerby, Robert E Hughes
Publikováno v:
PLoS Genetics, Vol 8, Iss 11, p e1003042 (2012)
A genome-scale RNAi screen was performed in a mammalian cell-based assay to identify modifiers of mutant huntingtin toxicity. Ontology analysis of suppressor data identified processes previously implicated in Huntington's disease, including proteolys
Externí odkaz:
https://doaj.org/article/175b1e0ba3254567b62e13171c7342da
Autor:
Sean D Mooney
Publikováno v:
The Journal of Applied Laboratory Medicine. 8:194-202
Background Artificial intelligence (AI) methods are becoming increasingly commonly implemented in healthcare as decision support, business intelligence tools, or, in some cases, Food and Drug Administration–approved clinical decision-makers. Advanc
Autor:
Vikas Pejaver, Alicia B. Byrne, Bing-Jian Feng, Kymberleigh A. Pagel, Sean D. Mooney, Rachel Karchin, Anne O’Donnell-Luria, Steven M. Harrison, Sean V. Tavtigian, Marc S. Greenblatt, Leslie G. Biesecker, Predrag Radivojac, Steven E. Brenner, Ahmad A. Tayoun, Jonathan S. Berg, Garry R. Cutting, Sian Ellard, Peter Kang, Izabela Karbassi, Jessica Mester, Tina Pesaran, Sharon E. Plon, Heidi L. Rehm, Natasha T. Strande, Scott Topper
Publikováno v:
The American Journal of Human Genetics. 109:2163-2177
Recommendations from the American College of Medical Genetics and Genomics and the Association for Molecular Pathology (ACMG/AMP) for interpreting sequence variants specify the use of computational predictors as "supporting" level of evidence for pat
Autor:
Carlos Galicia Aguirre, Kizito-Tshitoko Tshilenge, Elena Battistoni, Alejandro Lopez-Ramirez, Swati Naphade, Kevin Perez, Sicheng Song, Sean D. Mooney, Simon Melov, Michelle E. Ehrlich, Lisa M. Ellerby
SUMMARYHuntington’s disease (HD) is a neurodegenerative disorder caused by an expansion of CAG repeats in exon 1 of theHTTgene, ultimately resulting in the generation of a mutant HTT (mHTT) protein. Although mHTT is expressed in various tissues, it
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b2bf30d3828038869b311787fb28c25a
https://doi.org/10.1101/2023.04.30.538872
https://doi.org/10.1101/2023.04.30.538872