Setting International Standards in Analyzing Patient-Reported Outcomes and Quality of Life Endpoints in Cancer Clinical Trials-Innovative Medicines Initiative (SISAQOL-IMI): stakeholder views, objectives, and procedures

Autor: Madeline Pe, Ahu Alanya, Ragnhild Sorum Falk, Cecilie Delphin Amdal, Kristin Bjordal, Jane Chang, Paul Cislo, Corneel Coens, Linda Dirven, Rebecca M Speck, Kristina Fitzgerald, Jayne Galinsky, Johannes M Giesinger, Bernhard Holzner, Saskia Le Cessie, Daniel O'Connor, Kathy Oliver, Vivek Pawar, Chantal Quinten, Michael Schlichting, Jinma Ren, Satrajit Roychoudhury, Martin J B Taphoorn, Galina Velikova, Lisa M Wintner, Ingolf Griebsch, Andrew Bottomley, Cat Bui, Nnadozie Emechebe, Rajesh Kamalakar, Elektra Papadopoulos, Kavita Sail, Rohini Sen, Sean C Turner, Kim Cocks, Jaap Reijneveld, Christoph Gerlinger, Karen Keating, Yun Su, Birgit Wolf, Miaomiao Ge, Anders Ingelgaard, Barbara Peil, Maarten Voorhaar, Brendon Wong, Gracia Dekanic Arbanas, Karin Kuljanic, Duska Petranovic, Ivana Rede, Juan Arraras, Stephen Joel Coons, Sonya Eremenco, Lindsey Murray, Bryce Reeve, Corinne De Vries, Ralf Herold, Francesco Pignatti, Abigirl Machingura, Francesca Martinelli, Jammbe Musoro, Martine Piccart, Jorge Barriuso, Nathan Cherny, Ourania Dafni, Elisabeth De Vries, Bishal Gyawali, Barbara Kiesewetter, Sjoukje Oosting, Felipe Roitberg, Gerhard Rumpold, Felix Schoepf, Michael Tschuggnall, Jennifer Black, Maxime Sasseville, Katherine Soltys, Montserrat Ferrer, Olatz Garin, Gemma Vilagut, Christoph Schürmann, Stefanie Thomas, Beate Wieseler, Claire Snyder, Ariel Alonso Abad, Kris Bogaerts, Febe Brackx, Geert Molenberghs, Geert Verbeke, Cristián Frigolett Catalan, Jan Choi, Doranne Thomassen, Jan Geissler, Willi Sauerbrei, Franziska Gross, Micha Johannes Pilz, Yolanda Barbachano, Lisa Campbell, Khadija Rantell, Gregoire Desplanques, Antoine Regnault, Kate Morgan, Ananda Plate, Silene ten Seldam, Mitsumi Terada, Junki Mizusawa, Sandra Mitchell, Ashley Wilder Smith, Tove Ragna Reksten, Anja Schiel, Kenth Louis Hansen Joseph, Alicyn Campbell, Joseph Cappelleri, Patrizia de Besi, Alexander Russell-Smith, Rickard Sandin, Carla Mamolo, Michael Brundage, Dongsheng Tu, Mogens Groenvold, Morten Petersen, Charlie Cleeland, Lori Williams, Xin Shelley Wang, Jolie Ringash, Melanie Calvert, Samantha Cruz Rivera, Olalekan Lee Aiyegbusi, Els Goetghebeur, Limin Liu, Kelly Van Lancker, Florien Boele, Alexandra Gilbert, Rosemary Peacock, Ethan Basch, Madeleine King, Claudia Rutherford, Vishal Bhatnagar, Mallorie Fiero, Erica Horodniceanu, Laura Lee Johnson, Paul Kluetz, Lisa Rodriguez

Publikováno v: SISAQOL-IMI Consortium & et al. 2023, ' Setting International Standards in Analyzing Patient-Reported Outcomes and Quality of Life Endpoints in Cancer Clinical Trials-Innovative Medicines Initiative (SISAQOL-IMI): stakeholder views, objectives, and procedures ', Lancet Oncology, vol. 24, no. 6, pp. e270-e283 . https://doi.org/10.1016/S1470-2045(23)00157-2

Patient-reported outcomes (PROs), such as symptoms, functioning, and other health-related quality-of-life concepts are gaining a more prominent role in the benefit–risk assessment of cancer therapies. However, varying ways of analysing, presenting,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c9c09b5d5b8e72fb9e0a912f8763409
https://research.manchester.ac.uk/en/publications/0a737d16-9496-4acc-8a64-8e7eca001879

Microwave-Assisted Synthesis of Nitro-Substituted Tetrahydropyrido­azepines

Autor: Wilfried M. Braje, Thomas Schultz, Sean C. Turner

Publikováno v: Synthesis. 2010:1339-1343

The microwave-assisted condensation of azepan-4-ones with 3,5-dinitro-1-methylpyridin-2-one in the presence of ammonia was found to be a highly efficient method for the synthesis of nitro-substituted tetrahydropyridoazepines. Variation of the substit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::955f7dad21fc8042e607ef51d1842a4b
https://doi.org/10.1055/s-0029-1218678

A-272651, a nonpeptidic blocker of large-conductance Ca2+ -activated K+ channels, modulates bladder smooth muscle contractility and neuronal action potentials

Autor: Ivan Milicic, Steven A. Buckner, A Parihar, Murali Gopalakrishnan, X.-F Zhang, Sean C. Turner, J Wilkins, Char-Chang Shieh, Jinkerson T

Publikováno v: British Journal of Pharmacology. 151:798-806

Background and Purpose: The large-conductance Ca2+-activated K+ channel (BKCa, KCa1.1) links membrane excitability with intracellular Ca2+ signaling and plays important roles in smooth muscle contraction, neuronal firing, and neuroendocrine secretion

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e19b7f6e179b97773dd91e7971064c04
https://doi.org/10.1038/sj.bjp.0707278

Anticonvulsant effects of structurally diverse GABA(B) positive allosteric modulators in the DBA/2J audiogenic seizure test: Comparison to baclofen and utility as a pharmacodynamic screening model

Autor: Lynne E. Rueter, Achim Moeller, Martin Schmidt, Volker Nimmrich, Min Zhang, Elizabeth van der Kam, Sean C. Turner, Junli Ma, Jordan W. Brown

Publikováno v: Neuropharmacology. 101

The GABA(B) receptor has been indicated as a promising target for multiple CNS-related disorders. Baclofen, a prototypical orthosteric agonist, is used clinically for the treatment of spastic movement disorders, but is associated with unwanted side-e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b1200a95eb1a41649098d370a55c118
https://pubmed.ncbi.nlm.nih.gov/26471422

Medicinal Chemistry of Ca 2+ ‐activated K + Channel Modulators

Autor: Sean C. Turner, Char-Chang Shieh

Publikováno v: Voltage-Gated Ion Channels as Drug Targets, Volume 29

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1aec5490c229676782739f110a4da8db
https://doi.org/10.1002/3527608141.ch7d