Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Sean C. Tompkins"'
Autor:
Sean C. Tompkins, Ryan D. Sheldon, Adam J. Rauckhorst, Maria F. Noterman, Shane R. Solst, Jane L. Buchanan, Kranti A. Mapuskar, Alvin D. Pewa, Lawrence R. Gray, Lalita Oonthonpan, Arpit Sharma, Diego A. Scerbo, Adam J. Dupuy, Douglas R. Spitz, Eric B. Taylor
Publikováno v:
Cell Reports, Vol 28, Iss 10, Pp 2608-2619.e6 (2019)
Summary: Hepatocellular carcinoma (HCC) is a devastating cancer increasingly caused by non-alcoholic fatty liver disease (NAFLD). Disrupting the liver Mitochondrial Pyruvate Carrier (MPC) in mice attenuates NAFLD. Thus, we considered whether liver MP
Externí odkaz:
https://doaj.org/article/29feff27e7dd4d07ab314d89da837088
Autor:
Arpit Sharma, Lalita Oonthonpan, Ryan D Sheldon, Adam J Rauckhorst, Zhiyong Zhu, Sean C Tompkins, Kevin Cho, Wojciech J Grzesik, Lawrence R Gray, Diego A Scerbo, Alvin D Pewa, Emily M Cushing, Michael C Dyle, James E Cox, Chris Adams, Brandon S Davies, Richard K Shields, Andrew W Norris, Gary Patti, Leonid V Zingman, Eric B Taylor
Publikováno v:
eLife, Vol 8 (2019)
Metabolic cycles are a fundamental element of cellular and organismal function. Among the most critical in higher organisms is the Cori Cycle, the systemic cycling between lactate and glucose. Here, skeletal muscle-specific Mitochondrial Pyruvate Car
Externí odkaz:
https://doaj.org/article/13cd1adfdce945bdbb60969f1404d117
Autor:
Eric B. Taylor, Kevin Cho, Emily M. Cushing, Christopher M. Adams, Brandon S.J. Davies, Gary J. Patti, James E. Cox, Diego A Scerbo, Zhiyong Zhu, Lawrence R. Gray, Adam J. Rauckhorst, Wojciech J. Grzesik, Richard K. Shields, Michael C. Dyle, Arpit Sharma, Lalita Oonthonpan, Sean C. Tompkins, Andrew W. Norris, Leonid V. Zingman, Ryan D. Sheldon, Alvin D. Pewa
Publikováno v:
eLife, Vol 8 (2019)
eLife
eLife
Metabolic cycles are a fundamental element of cellular and organismal function. Among the most critical in higher organisms is the Cori Cycle, the systemic cycling between lactate and glucose. Here, skeletal muscle-specific Mitochondrial Pyruvate Car
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2177ec19b7bfb3092c484e6534c92ae6
https://doi.org/10.7554/elife.45873
https://doi.org/10.7554/elife.45873
Autor:
Lawrence R. Gray, Michael C. Dyle, Kevin Cho, Andrew W. Norris, Arpit Sharma, Alvin D. Pewa, Eric B. Taylor, Emily M. Cushing, Christopher M. Adams, Adam J. Rauckhorst, Leonid V. Zingman, Zhiyong Zhu, Sean C. Tompkins, Lalita Oonthonpan, Richard K. Shields, Ryan D. Sheldon, Wojciech J. Grzesik, Diego A Scerbo, Brandon S.J. Davies, James E. Cox, Gary J. Patti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d6fd7c09a9ed6c3c31f52227e1340afa
https://doi.org/10.7554/elife.45873.027
https://doi.org/10.7554/elife.45873.027
Autor:
Erin E. Lane, Lalita Oonthonpan, James E. Cox, Shawn C. Burgess, Jared Rutter, Ashley Dohlman, Matthew J. Potthoff, Lawrence R. Gray, Sean C. Tompkins, Adam J. Rauckhorst, Jianxin Xie, Arpit Sharma, Ren Miao, Kathryn S. Brown, Andrew W. Norris, Alvin D. Pewa, Eric B. Taylor, Diana Zepeda-Orozco, Xiaorong Fu, Mst Rasheda Sultana
Publikováno v:
Cell Metabolism. 22(4):669-681
SummaryGluconeogenesis is critical for maintenance of euglycemia during fasting. Elevated gluconeogenesis during type 2 diabetes (T2D) contributes to chronic hyperglycemia. Pyruvate is a major gluconeogenic substrate and requires import into the mito
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8539d20edf7ac7da737f89bf45f6aa62
Publikováno v:
Cellular and Molecular Life Sciences
Pyruvate is a keystone molecule critical for numerous aspects of eukaryotic and human metabolism. Pyruvate is the end-product of glycolysis, is derived from additional sources in the cellular cytoplasm, and is ultimately destined for transport into m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb6e2512046f4078f0f18cb38ca8c11b
https://doi.org/10.1007/s00018-013-1539-2
https://doi.org/10.1007/s00018-013-1539-2