Zobrazeno 1 - 10
of 39
pro vyhledávání: '"Sean C. Little"'
Autor:
Brian R. Anderson, Marianne L. Jensen, Peter H. Hagedorn, Sean C. Little, Richard E. Olson, Ron Ammar, Bernadette Kienzle, John Thompson, Ivar McDonald, Stephen Mercer, Jonas Vikesaa, Bettina Nordbo, Larry Iben, Yang Cao, Joanne Natale, Greg Dalton-Kay, Angela Cacace, Bo R. Hansen, Maj Hedtjärn, Troels Koch, Linda J. Bristow
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 19, Iss , Pp 1290-1298 (2020)
Hundreds of dominant-negative myosin mutations have been identified that lead to hypertrophic cardiomyopathy, and the biomechanical link between mutation and disease is heterogeneous across this patient population. To increase the therapeutic feasibi
Externí odkaz:
https://doaj.org/article/ebaf673f331045b1903490834433fa8c
Autor:
Jennifer M. Peterson, David J. Wang, Vikram Shettigar, Steve R. Roof, Benjamin D. Canan, Nadine Bakkar, Jonathan Shintaku, Jin-Mo Gu, Sean C. Little, Nivedita M. Ratnam, Priya Londhe, Leina Lu, Christopher E. Gaw, Jennifer M. Petrosino, Sandya Liyanarachchi, Huating Wang, Paul M. L. Janssen, Jonathan P. Davis, Mark T. Ziolo, Sudarshana M. Sharma, Denis C. Guttridge
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
The molecular mechanisms leading to heart failure in patients with Duchenne muscular dystrophy are unclear. Here the authors show that NF-κB is activated in the heart of dystrophin-deficient mice and that its ablation rescues cardiac function throug
Externí odkaz:
https://doaj.org/article/aa724b3e4c7b4ada9b67a708841b1195
Autor:
Xiaoping Liu, Mohamed A. El-Mahdy, James Boslett, Saradhadevi Varadharaj, Craig Hemann, Tamer M. Abdelghany, Raed S. Ismail, Sean C. Little, Danlei Zhou, Le Thi Thanh Thuy, Norifumi Kawada, Jay L. Zweier
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
The gaseous signalling molecule nitric oxide regulates vascular tone. Here, the authors show that nitric oxide is degraded by the enzyme cytoglobin in the vascular wall, and that mice lacking cytoglobin have reduced blood pressure and are less sensit
Externí odkaz:
https://doaj.org/article/7c48b88ebe1f45628a4d604983c1bc11
Autor:
Vikram Shettigar, Bo Zhang, Sean C. Little, Hussam E. Salhi, Brian J. Hansen, Ning Li, Jianchao Zhang, Steve R. Roof, Hsiang-Ting Ho, Lucia Brunello, Jessica K. Lerch, Noah Weisleder, Vadim V. Fedorov, Federica Accornero, Jill A. Rafael-Fortney, Sandor Gyorke, Paul M. L. Janssen, Brandon J. Biesiadecki, Mark T. Ziolo, Jonathan P. Davis
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
Heart contraction, which is decreased in disease, is determined by Ca2+binding to troponin C. Here, the authors combine a protein engineering approach with gene therapy to modulate heart contractility in mice with the use of rationally designed Tropo
Externí odkaz:
https://doaj.org/article/9828c585327046c3b5306a0cb5e0d215
Autor:
Bo Hansen, Brian R. Anderson, Linda J. Bristow, Jonas Vikesaa, Sean C. Little, JoAnne E Natale, Maj Hedtjarn, Greg Dalton-Kay, John Ryan Thompson, Yang Cao, Peter Hagedorn, Marianne Lerbech Jensen, Ivar M. McDonald, Bernadette Kienzle, Larry Iben, Stephen E. Mercer, Bettina Nordbo, Angela Cacace, Troels Koch, Richard E. Olson, Ron Ammar
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 19, Iss, Pp 1290-1298 (2020)
Molecular Therapy. Nucleic Acids
Molecular Therapy. Nucleic Acids
Hundreds of dominant-negative myosin mutations have been identified that lead to hypertrophic cardiomyopathy, and the biomechanical link between mutation and disease is heterogeneous across this patient population. To increase the therapeutic feasibi
Autor:
Danlei Zhou, Sean C. Little, Jay L. Zweier, Craig Hemann, Norifumi Kawada, James Boslett, Mohamed A. El-Mahdy, Raed S. Ismail, Xiaoping Liu, Saradhadevi Varadharaj, Le Thi Thanh Thuy, Tamer M. Abdelghany
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
Nature Communications
Nature Communications
The identity of the specific nitric oxide dioxygenase (NOD) that serves as the main in vivo regulator of O2-dependent NO degradation in smooth muscle remains elusive. Cytoglobin (Cygb) is a recently discovered globin expressed in fibroblasts and smoo
Autor:
Svetlana B. Tikunova, Vikram Shettigar, Paul M.L. Janssen, Jonathan P. Davis, Bin Liu, Sean C. Little, Shane D. Walton, Mark T. Ziolo, Jalal K. Siddiqui
Publikováno v:
Archives of Biochemistry and Biophysics. 601:4-10
Throughout history, muscle research has led to numerous scientific breakthroughs that have brought insight to a more general understanding of all biological processes. Potentially one of the most influential discoveries was the role of the second mes
Autor:
Huating Wang, Jin Mo Gu, Jennifer M. Peterson, Sandya Liyanarachchi, Christopher E. Gaw, Vikram Shettigar, Mark T. Ziolo, Benjamin D. Canan, Jennifer M. Petrosino, Steve R. Roof, Sudarshana M. Sharma, Denis C. Guttridge, Nadine Bakkar, David J. Wang, Leina Lu, Paul M.L. Janssen, Jonathan P. Davis, Sean C. Little, Priya Londhe, Jonathan Shintaku, Nivedita M. Ratnam
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
Nature Communications
Nature Communications
Duchenne muscular dystrophy (DMD) is a neuromuscular disorder causing progressive muscle degeneration. Although cardiomyopathy is a leading mortality cause in DMD patients, the mechanisms underlying heart failure are not well understood. Previously,
Autor:
Elisa A. Bradley, Thomas J. Hund, Paul M.L. Janssen, Jerry Curran, Penelope A. Boyden, Sathya D. Unudurthi, Hassan Musa, Michael A. Makara, Murugesan V. S. Rajaram, Nathaniel P. Murphy, Peter J. Mohler, Sakima A. Smith, Sean C. Little, Ellen R. Lubbers
Publikováno v:
JACC: Basic to Translational Science
Visual Abstract
Highlights • The pathogenesis of human heart failure is complex, and the creation of new therapeutic strategies for human heart failure is critical. • Identifying the molecular pathways underlying heart failure is important t
Highlights • The pathogenesis of human heart failure is complex, and the creation of new therapeutic strategies for human heart failure is critical. • Identifying the molecular pathways underlying heart failure is important t
Autor:
Crystal F. Kline, Thomas J. Hund, Sean C. Little, Hassan Musa, Hamid Band, Michael A. Makara, Peter J. Mohler, John D. Higgins, Jerry Curran
Publikováno v:
Journal of Biological Chemistry. 290:12210-12221
Proper trafficking of membrane-bound ion channels and transporters is requisite for normal cardiac function. Endosome-based protein trafficking of membrane-bound ion channels and transporters in the heart is poorly understood, particularly in vivo. I