Contextual fear memory retrieval by correlated ensembles of ventral CA1 neurons

Autor: Jessica C. Jimenez, Jack E. Berry, Sean C. Lim, Samantha K. Ong, Mazen A. Kheirbek, Rene Hen

Publikováno v: Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020)

The vCA1-BA projection is enriched in shock responsive neurons, which are necessary for fear memory encoding and become correlated with a network of neurons during retrieval. Here the authors show that the magnitude of vCA1 correlated activity is pro

Externí odkaz: https://doaj.org/article/b1ae9cbb452a4a1cb40c60fdbc9c5b59

Distinct hippocampal engrams control extinction and relapse of fear memory

Autor: Michael R. Drew, Kevin P. Sattler, Chelsea R. Crovetti, Francis Shue, Christine A. Denny, Anthony F. Lacagnina, Sean C. Lim, Meredith J. McCarty, Sofia Leal Santos, Emma T. Brockway

Publikováno v: Nature neuroscience
Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP

Learned fear often relapses after extinction, suggesting that extinction training generates a new memory that coexists with the original fear memory; however, the mechanisms governing the expression of competing fear and extinction memories remain un

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::056cd67c575ca32c383e31cad03e4710
https://hdl.handle.net/1822/67217

Ketamine as a Prophylactic Against Stress-Induced Depressive-like Behavior

Autor: Josephine C. McGowan, Alain M. Gardier, Sean C. Lim, Jennifer N. Perusini, Christine A. Denny, Thu Ha Pham, René Hen, Denis J. David, Charlène Faye, Indira Mendez-David, Rebecca A. Brachman

Publikováno v: ResearcherID

Background Stress exposure is one of the greatest risk factors for psychiatric illnesses like major depressive disorder and posttraumatic stress disorder. However, not all individuals exposed to stress develop affective disorders. Stress resilience,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a044cfd85a1d7d3015347b6447e990b
https://doi.org/10.1016/j.biopsych.2015.04.022

A Social Network Approach Reveals Associations between Mouse Social Dominance and Brain Gene Expression

Autor: Sean C. Lim, James P. Curley, Nina So, Becca Franks

Publikováno v: PLoS ONE, Vol 10, Iss 7, p e0134509 (2015)
PLoS ONE

Modelling complex social behavior in the laboratory is challenging and requires analyses of dyadic interactions occurring over time in a physically and socially complex environment. In the current study, we approached the analyses of complex social i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b86442df73ad2b3120cd3f4c374553b
http://europepmc.org/articles/PMC4520683?pdf=render