Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Sean C. Godar"'
Autor:
Laura J. Mosher, Sean C. Godar, Marianela Nelson, Stephen C. Fowler, Graziano Pinna, Marco Bortolato
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-9 (2017)
Abstract Tourette syndrome (TS) is a neuropsychiatric disorder characterized by multiple tics and sensorimotor abnormalities, the severity of which is typically increased by stress. The neurobiological underpinnings of this exacerbation, however, rem
Externí odkaz:
https://doaj.org/article/3ab4a6989ba3454dac75b5a92be0ee11
Autor:
Sean C. Godar, Roberto Cadeddu, Gabriele Floris, Laura J. Mosher, Zhen Mi, David P. Jarmolowicz, Simona Scheggi, Alicia A. Walf, Carolyn J. Koonce, Cheryl A. Frye, Nancy A. Muma, Marco Bortolato
Publikováno v:
Biomolecules, Vol 9, Iss 11, p 749 (2019)
Finasteride (FIN) is the prototypical inhibitor of steroid 5α-reductase (5αR), the enzyme that catalyzes the rate-limiting step of the conversion of progesterone and testosterone into their main neuroactive metabolites. FIN is clinically approved f
Externí odkaz:
https://doaj.org/article/baf95fecf4604756a46e4525aef8e736
Autor:
Marco Bortolato, Sean C. Godar
Publikováno v:
Interdisciplinary Perspectives on Infectious Diseases, Vol 2010 (2010)
Converging lines of clinical and epidemiological evidence suggest that viral infections in early developmental stages may be a causal factor in neuropsychiatric disorders such as schizophrenia, bipolar disorder, and autism-spectrum disorders. This et
Externí odkaz:
https://doaj.org/article/142a1eb1f56e4202b0a249b5c16e8cb8
Autor:
Tara A. Lavelle, David A. Adler, Debra Lerner, Hong Chang, Sean C Godar, Wing Chow, William H. Rogers
Publikováno v:
Journal of Occupational and Environmental Medicine
Objective To describe caregiving work outcomes and related indirect (ie, productivity) and direct (ie, caregiving hours and expenses) costs. Methods A national, population-based survey to identify employed caregivers assisting a person with treatment
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::302a599c481412d3d07519e3444b25e7
https://doi.org/10.1097/jom.0000000000001957
https://doi.org/10.1097/jom.0000000000001957
Autor:
Brock R. Pluimer, Yijie Geng, Devin L. Harrison, Anjali K. Nath, Randall T. Peterson, Iain A. Drummond, Sean C. Godar, Jing-Ruey J. Yeh, Marco Bortolato, Tejia Zhang
Human infants exhibit innate social behaviors at birth, yet little is understood about the embryonic development of sociality. We screened 1120 known drugs and found that embryonic inhibition of topoisomerase IIα (Top2a) resulted in lasting social d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::176b82ef78ae6e81a80d7544af21c4de
https://doi.org/10.1101/2021.09.20.461107
https://doi.org/10.1101/2021.09.20.461107
Autor:
Marco Bortolato, Sean C. Godar, Simona Scheggi, Kenneth M. McFarlin, Laura J. Mosher, Marc Morissette, Carla Gambarana, Stephen C. Fowler, Thérèse Di Paolo
Publikováno v:
Psychoneuroendocrinology. 91:95-104
The enzyme steroid 5α-reductase 2 (5αR2) catalyzes the conversion of testosterone into the potent androgen 5α-dihydrotestosterone. Previous investigations showed that 5αR2 is expressed in key brain areas for emotional and socio-affective reactivi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f248500f62dd7dee3d65ee22f0ddac3
https://doi.org/10.1016/j.psyneuen.2018.02.007
https://doi.org/10.1016/j.psyneuen.2018.02.007
Autor:
Marco Bortolato, Sean C. Godar
Publikováno v:
Neuroscience & Biobehavioral Reviews. 76:123-133
Tourette syndrome (TS) is a neurodevelopmental condition characterized by multiple, recurring motor and phonic tics. Rich empirical evidence shows that the severity of tics and associated manifestations is increased by several stressors and contextua
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04f2d7363f0c1f698df843927b4eb043
https://doi.org/10.1016/j.neubiorev.2016.10.003
https://doi.org/10.1016/j.neubiorev.2016.10.003
Autor:
Zhen Mi, Sean C. Godar, Roberto Cadeddu, Alicia A. Walf, Nancy A. Muma, Gabriele Floris, Marco Bortolato, Simona Scheggi, Carolyn J. Koonce, Cheryl A. Frye, David P. Jarmolowicz, Laura J. Mosher
Publikováno v:
Biomolecules
Volume 9
Issue 11
Biomolecules, Vol 9, Iss 11, p 749 (2019)
Volume 9
Issue 11
Biomolecules, Vol 9, Iss 11, p 749 (2019)
Finasteride (FIN) is the prototypical inhibitor of steroid 5&alpha
reductase (5&alpha
R), the enzyme that catalyzes the rate-limiting step of the conversion of progesterone and testosterone into their main neuroactive metabolites. FIN is cl
reductase (5&alpha
R), the enzyme that catalyzes the rate-limiting step of the conversion of progesterone and testosterone into their main neuroactive metabolites. FIN is cl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1058cdd0a870b62730671a25a0b5a538
Autor:
Miriam Melis, Paola Devoto, Sean C. Godar, Valeria Serra, Nicola Simola, Francesco Traccis, Silvia Fanni, Marco Bortolato, Roberto Frau
Publikováno v:
Neuropharmacology. 159
Aggressive behavior (AB) is a multifaceted disorder based on the interaction between genetic and environmental factors whose underlying mechanisms remain elusive. The best-characterized gene by environment (GxE) interaction for AB is the relationship
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62b6466dc878dc4981a25601ec5ef23e
https://pubmed.ncbi.nlm.nih.gov/30738037
https://pubmed.ncbi.nlm.nih.gov/30738037
Autor:
Marco Bortolato, Andrea M Gochi, Laura J. Mosher, Hunter J. Strathman, Sean C. Godar, Cori M. Jones, Stephen C. Fowler
Publikováno v:
British Journal of Pharmacology. 173:2111-2121
Background and purpose The D1CT-7 mouse is one of the best known animal models of Tourette syndrome (TS), featuring spontaneous tic-like behaviours sensitive to standard TS therapies; these characteristics ensure a high face and predictive validity o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5b87ddcdfbab657b0411c533e181ce40
https://doi.org/10.1111/bph.13243
https://doi.org/10.1111/bph.13243