Zobrazeno 1 - 10
of 179
pro vyhledávání: '"Sean C. Bendall"'
Autor:
YeEun Kim, Ariel A. Calderon, Patricia Favaro, David R. Glass, Albert G. Tsai, Daniel Ho, Luciene Borges, William J. Greenleaf, Sean C. Bendall
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract Lymphoid specification in human hematopoietic progenitors is not fully understood. To better associate lymphoid identity with protein-level cell features, we conduct a highly multiplexed single-cell proteomic screen on human bone marrow prog
Externí odkaz:
https://doaj.org/article/051d1acc4a3e494b86aac1b487e294fc
Autor:
Loukia G. Karacosta, Danny Pancirer, Jordan S. Preiss, Jalen A. Benson, Winston Trope, Joseph B. Shrager, Arthur Wai Sung, Joel W. Neal, Sean C. Bendall, Heather Wakelee, Sylvia K. Plevritis
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-11 (2023)
Abstract Malignant pleural effusions (MPEs) can be utilized as liquid biopsy for phenotyping malignant cells and for precision immunotherapy, yet MPEs are inadequately studied at the single-cell proteomic level. Here we leverage mass cytometry to int
Externí odkaz:
https://doaj.org/article/d8612f1f48db4c5a98c79cd070079b2b
Autor:
Juraj Adamik, Paul V. Munson, Deena M. Maurer, Felix J. Hartmann, Sean C. Bendall, Rafael J. Argüello, Lisa H. Butterfield
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-19 (2023)
Abstract Efficacy of cancer vaccines remains low and mechanistic understanding of antigen presenting cell function in cancer may improve vaccine design and outcomes. Here, we analyze the transcriptomic and immune-metabolic profiles of Dendritic Cells
Externí odkaz:
https://doaj.org/article/2aded29557e34daa92edbec323f7a483
Autor:
Eloïse Berson, Chandresh R. Gajera, Thanaphong Phongpreecha, Amalia Perna, Syed A. Bukhari, Martin Becker, Alan L. Chang, Davide De Francesco, Camilo Espinosa, Neal G. Ravindra, Nadia Postupna, Caitlin S. Latimer, Carol A. Shively, Thomas C. Register, Suzanne Craft, Kathleen S. Montine, Edward J. Fox, C. Dirk Keene, Sean C. Bendall, Nima Aghaeepour, Thomas J. Montine
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-12 (2023)
Abstract Comparing brain structure across species and regions enables key functional insights. Leveraging publicly available data from a novel mass cytometry-based method, synaptometry by time of flight (SynTOF), we applied an unsupervised machine le
Externí odkaz:
https://doaj.org/article/e5e3833350304b12a691ca6d66566e5f
Autor:
Yunhao Bai, Bokai Zhu, John-Paul Oliveria, Bryan J. Cannon, Dorien Feyaerts, Marc Bosse, Kausalia Vijayaragavan, Noah F. Greenwald, Darci Phillips, Christian M. Schürch, Samuel M. Naik, Edward A. Ganio, Brice Gaudilliere, Scott J. Rodig, Michael B. Miller, Michael Angelo, Sean C. Bendall, Xavier Rovira-Clavé, Garry P. Nolan, Sizun Jiang
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-18 (2023)
Abstract Cellular organization and functions encompass multiple scales in vivo. Emerging high-plex imaging technologies are limited in resolving subcellular biomolecular features. Expansion Microscopy (ExM) and related techniques physically expand sa
Externí odkaz:
https://doaj.org/article/1aaa853ff55a4176b7b32d00970f18f6
Autor:
Jolanda Sarno, Pablo Domizi, Yuxuan Liu, Milton Merchant, Christina Bligaard Pedersen, Dorra Jedoui, Astraea Jager, Garry P. Nolan, Giuseppe Gaipa, Sean C. Bendall, Felice-Alessio Bava, Kara L. Davis
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
Abstract Resistance to glucocorticoids (GC) is associated with an increased risk of relapse in B-cell progenitor acute lymphoblastic leukemia (BCP-ALL). Performing transcriptomic and single-cell proteomic studies in healthy B-cell progenitors, we her
Externí odkaz:
https://doaj.org/article/72794963275b43be963a12304dd22407
Autor:
Kausalia Vijayaragavan, Bryan J. Cannon, Dmitry Tebaykin, Marc Bossé, Alex Baranski, J. P. Oliveria, Syed A. Bukhari, Dunja Mrdjen, M. Ryan Corces, Erin F. McCaffrey, Noah F. Greenwald, Yari Sigal, Diana Marquez, Zumana Khair, Trevor Bruce, Mako Goldston, Anusha Bharadwaj, Kathleen S. Montine, R. Michael Angelo, Thomas J. Montine, Sean C. Bendall
Publikováno v:
Acta Neuropathologica Communications, Vol 10, Iss 1, Pp 1-22 (2022)
Abstract Neurodegenerative disorders are characterized by phenotypic changes and hallmark proteopathies. Quantifying these in archival human brain tissues remains indispensable for validating animal models and understanding disease mechanisms. We pre
Externí odkaz:
https://doaj.org/article/634355137dcd41ebab2eb6ab532fbf74
Autor:
Juraj Adamik, Paul V. Munson, Felix J. Hartmann, Alexis J. Combes, Philippe Pierre, Matthew F. Krummel, Sean C. Bendall, Rafael J. Argüello, Lisa H. Butterfield
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-19 (2022)
Assessing metabolic activity within single cells rather than at a population level has a number of advantages. Here, the authors use a flow and mass cytometry based approach that assess the metabolic differences between populations of human immune st
Externí odkaz:
https://doaj.org/article/27aa97b7359c4151be4e81d25e5af2d2
Autor:
Yu-Chen Lo, Timothy J. Keyes, Astraea Jager, Jolanda Sarno, Pablo Domizi, Ravindra Majeti, Kathleen M. Sakamoto, Norman Lacayo, Charles G. Mullighan, Jeffrey Waters, Bita Sahaf, Sean C. Bendall, Kara L. Davis
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
Challenges in batch normalization and data integration limit the comparison of existing mass cytometry datasets. Here, the authors report CytofIn that can integrate mass cytometry datasets from the public domain and reveal cellular features associate
Externí odkaz:
https://doaj.org/article/62feaf98a89e4b25a5f743a4912683d7
Autor:
Nora Vivanco Gonzalez, John-Paul Oliveria, Dmitry Tebaykin, Geoffrey T. Ivison, Kaori Mukai, Mindy M. Tsai, Luciene Borges, Kari C. Nadeau, Stephen J. Galli, Albert G. Tsai, Sean C. Bendall
Publikováno v:
STAR Protocols, Vol 3, Iss 2, Pp 101280- (2022)
Summary: Granulocytes encompass diverse roles, from fighting off pathogens to regulating inflammatory processes in allergies. These roles are represented by distinct cellular phenotypes that we captured with mass cytometry (CyTOF). Our protocol enabl
Externí odkaz:
https://doaj.org/article/8d36587891204e8cbabdf68a3ab50efb