Výsledky vyhledávání - "Sean C. Barron"

An Allosteric Modulator of α7 Nicotinic Receptors, N-(5-Chloro-2,4-dimethoxyphenyl)-N′-(5-methyl-3-isoxazolyl)-urea (PNU-120596), Causes Conformational Changes in the Extracellular Ligand Binding Domain Similar to Those Caused by Acetylcholine

Autor: Vanessa L. Richards, Jennifer A. See, James T. McLaughlin, Sean C. Barron, Robert L. Rosenberg

Publikováno v: Molecular Pharmacology. 76:253-263

Nicotinic acetylcholine receptors are implicated in several neuropsychiatric disorders, including nicotine addiction, Alzheimer's, schizophrenia, and depression. Therefore, they represent a critical molecular target for drug development and targeted

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1734eea8817a323184bac60044f67fdc
https://doi.org/10.1124/mol.109.056226

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Dual origins of functionally distinct O-LM interneurons revealed by differential 5-HT3AR expression

Autor: Sean C Barron, Ashley McFarland, Michael T. Craig, Xiaoqing Yuan, Brian E. Erkkila, Barry J. Liang, Ramesh Chittajallu, Ludovic Tricoire, Kenneth A. Pelkey, Scott Gerfen, Chris J. McBain, Brian W Jeffries, Carla M. Lopez

Publikováno v: Nature Neuroscience
Nature Neuroscience, Nature Publishing Group, 2013, 16 (11), pp.1598-1607. ⟨10.1038/nn.3538⟩
Nature Neuroscience, 2013, 16 (11), pp.1598-1607. ⟨10.1038/nn.3538⟩

International audience; Forebrain circuits rely upon a relatively small but remarkably diverse population of GABAergic interneurons to bind and entrain large principal cell assemblies for network synchronization and rhythmogenesis. Despite the high d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30b318dab29153865c274da3a5613dbb
https://hal.archives-ouvertes.fr/hal-01541370

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Conformational changes in alpha 7 acetylcholine receptors underlying allosteric modulation by divalent cations

Autor: Robert L. Rosenberg, James T. McLaughlin, Jennifer A. See, Sean C. Barron

Publikováno v: BMC Pharmacology

Allosteric modulation of membrane receptors is a widespread mechanism by which endogenous and exogenous agents regulate receptor function. For example, several members of the nicotinic receptor family are modulated by physiological concentrations of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2fab99b4697865da07cc892ac2a1705d

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Homology models of the alpha7 acetylcholine receptor based upon bacterial receptors: Comparison of experimental and in silico derived data

Autor: Sean C. Barron, James T. McLaughlin, Jennifer A. See, Robert L. Rosenberg, Brenda Temple

Publikováno v: Biochemical Pharmacology. 78:907-908

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ec0b4db6d47c49c530cfd13289aa7f1e
https://doi.org/10.1016/j.bcp.2009.06.050

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