Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Sean C Hensley"'
Autor:
Matthew J Yousefzadeh, David W Wyatt, Kei-Ichi Takata, Yunxiang Mu, Sean C Hensley, Junya Tomida, Göran O Bylund, Sylvie Doublié, Erik Johansson, Dale A Ramsden, Kevin M McBride, Richard D Wood
Publikováno v:
PLoS Genetics, Vol 10, Iss 10, p e1004654 (2014)
Although a defect in the DNA polymerase POLQ leads to ionizing radiation sensitivity in mammalian cells, the relevant enzymatic pathway has not been identified. Here we define the specific mechanism by which POLQ restricts harmful DNA instability. Ou
Externí odkaz:
https://doaj.org/article/4231e2dcb1ae482db01a1c9297868d19
Autor:
Tammy S. Wehr, Jianjun Shen, Ashby J. Morrison, Xuetong Shen, Sean C. Hensley, Yunhe Bao, Sean R. Collins, Jung-Ae Kim, Nevan J. Krogan, Jeff Delrow, Jessica Highland, Maria D. Person, James E. Haber, Jing Xiao, Jonathan S. Weissman
Publikováno v:
Cell. 130(3):499-511
SummaryThe yeast Mec1/Tel1 kinases, ATM/ATR in mammals, coordinate the DNA damage response by phosphorylating proteins involved in DNA repair and checkpoint pathways. Recently, ATP-dependent chromatin remodeling complexes, such as the INO80 complex,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1818fd4d2d2e9e4bff59ba66c3c249e6
Autor:
Sylvie Doublié, David W. Wyatt, Sean C. Hensley, Richard D. Wood, Kevin M. McBride, Göran O. Bylund, Junya Tomida, Yunxiang Mu, Erik Johansson, Kei Ichi Takata, Matthew J. Yousefzadeh, Dale A. Ramsden
Publikováno v:
PLoS Genetics
PLoS Genetics, Vol 10, Iss 10, p e1004654 (2014)
PLoS Genetics, Vol 10, Iss 10, p e1004654 (2014)
Although a defect in the DNA polymerase POLQ leads to ionizing radiation sensitivity in mammalian cells, the relevant enzymatic pathway has not been identified. Here we define the specific mechanism by which POLQ restricts harmful DNA instability. Ou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1bf2555b82a994f1999f0c480814d63
https://pubmed.ncbi.nlm.nih.gov/25275444
https://pubmed.ncbi.nlm.nih.gov/25275444
Publikováno v:
Molecular cell, vol 53, iss 3
Tudor domain containing protein 3 (TDRD3) is a major methyl-arginine effector molecule that “reads” methyl-histone marks and facilitates gene transcription. However, the underlying mechanism by which TDRD3 functions as a transcriptional coactivat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c13d9d357cb915cb1ae2d7a28b68bf85
https://europepmc.org/articles/PMC3959860/
https://europepmc.org/articles/PMC3959860/
Autor:
Maria D. Person, Okkyung Rho, Kaoru Kiguchi, Jianjun Shen, O. John Semmes, John DiGiovanni, Sean C. Hensley, Michael D. Ward, S. Alex McClellan, Joe M. Angel, Alexander Chau, Erika L. Abel, John Repass, Lisa J. Schroeder, Penny K. Riggs, Angelina Temple
Publikováno v:
Carcinogenesis. 33(11)
Genetic susceptibility to two-stage skin carcinogenesis is known to vary significantly among different stocks and strains of mice. In an effort to identify specific protein changes or altered signaling pathways associated with skin tumor promotion su
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb78e66e3d763652738a954bf2aeab22
https://pubmed.ncbi.nlm.nih.gov/22782996
https://pubmed.ncbi.nlm.nih.gov/22782996
Autor:
Maria D. Person, Sean C. Hensley, Kelli J. Kochan, Jianjun Shen, Penny K. Riggs, John DiGiovanni, Angelina Traner, Lisa J. Schroeder
Publikováno v:
Molecular carcinogenesis. 46(5)
Overexpression of insulin-like growth factor-1 (IGF-1) has been associated with a number of human tumors, including breast, colon, lung, and prostate cancers. In previous studies, we found that mice overexpressing human IGF-1 in the basal layer of th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a267f2e5ea17b51fe2082138763568c5
https://pubmed.ncbi.nlm.nih.gov/17330866
https://pubmed.ncbi.nlm.nih.gov/17330866
Autor:
Amy Pavone, Thom K. Chang, Jianjun Shen, Maria D. Person, Angelina Traner, Susan M. Fischer, Sean C. Hensley, Carol Mikulec
Publikováno v:
Journal of proteome research. 6(1)
Exposure of murine skin to tumor-promoting agents such as 12-O-tetradecanoyl-phorbol-13-acetate (TPA) causes up-regulation of cyclooxygenase-2 (COX-2) and increased prostaglandin (PG) synthesis. Pharmacological inhibition of COX-2 significantly reduc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5501b9284ba9d4c8eddf13b449a49e39
https://pubmed.ncbi.nlm.nih.gov/17203971
https://pubmed.ncbi.nlm.nih.gov/17203971
Autor:
Maria D, Person, Jianjun, Shen, Angelina, Traner, Sean C, Hensley, Herng-Hsiang, Lo, James L, Abbruzzese, Donghui, Li
Publikováno v:
Journal of biomolecular techniques : JBT. 17(2)
We previously reported a protein expression profiling experiment conducted on human pancreatic tissues using 2D gel electrophoresis and mass spectrometry. Here, 18 spots that were identified in the gel at molecular weights more than 10 kDa lower than
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::2211086f9fb2578ac045f487a1c915c9
https://pubmed.ncbi.nlm.nih.gov/16741242
https://pubmed.ncbi.nlm.nih.gov/16741242
Autor:
Jianjun Shen, Serrine S. Lau, Jing Dong, James L. Stevens, Terrence J. Monks, Zhe Jia, Maria D. Person, Sean C. Hensley
Publikováno v:
American journal of physiology. Renal physiology. 287(6)
11-Deoxy-16,16-dimethyl PGE2(DDM-PGE2) protects renal proximal tubule epithelial cells (LLC-PK1) against the toxicity induced by 2,3,5- tris(glutathion- S-yl)hydroquinone (TGHQ), a potent nephrotoxic and nephrocarcinogenic metabolite of hydroquinone.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7b8afcfc83ca8ee4be3ae6a7e99bc91
https://pubmed.ncbi.nlm.nih.gov/15522989
https://pubmed.ncbi.nlm.nih.gov/15522989
Autor:
Alexander Chau, Maria D. Person, Sean C. Hensley, John Repass, Erika L. Abel, Lisa J. Schroeder, Michael D. Ward, O. John Semmes, Joe M. Angel, Jianjun Shen, Penny K. Riggs, John DiGiovanni, Angelina Traner
Publikováno v:
Cancer Research. 71:2729-2729
Genetic susceptibility to two-stage skin carcinogenesis is known to vary significantly among different stocks and strains of mice. In an effort to identify specific protein changes or altered signaling pathways associated with tumor promotion suscept
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5b276ffad373aa30ba3597aa2271b749
https://doi.org/10.1158/1538-7445.am2011-2729
https://doi.org/10.1158/1538-7445.am2011-2729