Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Sean Austin O. Lim"'
Autor:
Sean Austin O. Lim, D. James Surmeier
Publikováno v:
Frontiers in Systems Neuroscience, Vol 14 (2021)
Huntington's disease (HD) is an autosomal dominant neurodegenerative disorder that initially manifests itself in the striatum. How intrastriatal circuitry is altered by the disease is poorly understood. To help fill this gap, the circuitry linking sp
Externí odkaz:
https://doaj.org/article/0346e9cee8f744ae832ad3db6326cbe6
Autor:
Sean Austin O. Lim, Rong Xia, Yunmin Ding, Lisa Won, William J. Ray, Stephen A. Hitchcock, Daniel S. McGehee, Un Jung Kang
Publikováno v:
Neurobiology of Disease, Vol 76, Iss , Pp 67-76 (2015)
Levodopa is the most effective therapy for the motor deficits of Parkinson's disease (PD), but long term treatment leads to the development of l-DOPA-induced dyskinesia (LID). Our previous studies indicate enhanced excitability of striatal cholinergi
Externí odkaz:
https://doaj.org/article/250b8769fd3246af8e7899fcd8c6a4bb
Publikováno v:
Frontiers Research Topics ISBN: 9782832518762
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::408bb5a4fa5f198b6b9bc45e0ea343c2
https://doi.org/10.3389/978-2-83251-876-2
https://doi.org/10.3389/978-2-83251-876-2
Autor:
Sean Austin O, Lim
Publikováno v:
J Undergrad Neurosci Educ
The steadily-rising cost of higher education is a tremendous financial burden, and the purchasing of textbooks represents a significant cost of higher education. Financial hardship exaggerates wealth disparities, decreasing the diversity of learners.
Autor:
Sean Austin O, Lim, D James, Surmeier
Publikováno v:
Frontiers in Systems Neuroscience
Huntington's disease (HD) is an autosomal dominant neurodegenerative disorder that initially manifests itself in the striatum. How intrastriatal circuitry is altered by the disease is poorly understood. To help fill this gap, the circuitry linking sp
Autor:
Sean Austin O. Lim, Asami Tanimura, Tristano Pancani, Weixing Shen, Cecilia Tubert, Dalton James Surmeier, Alexandra E. Melendez
Publikováno v:
European Journal of Neuroscience. 47:1148-1158
Giant, aspiny cholinergic interneurons (ChIs) have long been known to be key nodes in the striatal circuitry controlling goal-directed actions and habits. In recent years, new experimental approaches, like optogenetics and monosynaptic rabies virus m
Autor:
D. James Surmeier, Jose de Jesus Aceves Buendia, Joshua A. Goldberg, Asami Tanimura, Sean Austin O. Lim
Publikováno v:
Frontiers in Systems Neuroscience
Frontiers in Systems Neuroscience, Vol 10 (2016)
Frontiers in Systems Neuroscience, Vol 10 (2016)
Huntington’s disease (HD) is a neurodegenerative disorder characterized by deficits in movement control that are widely viewed as stemming from pathophysiological changes in the striatum. Giant, aspiny cholinergic interneurons (ChIs) are key elemen
Autor:
Lisa Won, Yunmin Ding, Un Jung Kang, Sean Austin O. Lim, Jonathan P. Britt, Daniel S. McGehee
Publikováno v:
Proceedings of the National Academy of Sciences. 108:840-845
Treatment of Parkinson disease (PD) with l -3,4-dihydroxyphenylalanine ( l -DOPA) dramatically relieves associated motor deficits, but l -DOPA–induced dyskinesias (LID) limit the therapeutic benefit over time. Previous investigations have noted cha
Publikováno v:
Frontiers in Synaptic Neuroscience, Vol 6 (2014)
Frontiers in Synaptic Neuroscience
Frontiers in Synaptic Neuroscience
The striatum plays a central role in motor control and motor learning. Appropriate responses to environmental stimuli, including pursuit of reward or avoidance of aversive experience all require functional striatal circuits. These pathways integrate
Autor:
Kristina E. Hoque, Anthony R. West, John Linardakis, Golta Rasouli, Brian Klika, Sean Austin O. Lim, Stephen Sammut, Sawrav Josh Mukherji, Sarah Threlfell, Janie M. Ondracek, Migena Burnazi, Alexander M. Dec, Raksha P. Indorkar
Publikováno v:
The European journal of neuroscience. 27(7)
The gaseous neurotransmitter nitric oxide plays an important role in the modulation of corticostriatal synaptic transmission. This study examined the impact of frontal cortex stimulation on striatal nitric oxide efflux and neuron activity in urethane