Zobrazeno 1 - 10
of 39
pro vyhledávání: '"Sean A. Newmister"'
Autor:
Colleen E. Yancey, Lauren Hart, Sierra Hefferan, Osama G. Mohamed, Sean A. Newmister, Ashootosh Tripathi, David H. Sherman, Gregory J. Dick
Publikováno v:
mSystems, Vol 9, Iss 7 (2024)
ABSTRACT Microcystis spp. are renowned for producing the hepatotoxin microcystin in freshwater cyanobacterial harmful algal blooms around the world, threatening drinking water supplies and public and environmental health. However, Microcystis genomes
Externí odkaz:
https://doaj.org/article/5b73efee23e84b3990a0d2dfb261fac0
Autor:
Zhiwen Liu, Sebastian Rivera, Sean A. Newmister, Jacob N. Sanders, Qiuyue Nie, Shuai Liu, Fanglong Zhao, Joseph D. Ferrara, Hao-Wei Shih, Siddhant Patil, Weijun Xu, Mitchell D. Miller, George N. Phillips, K. N. Houk, David H. Sherman, Xue Gao
Publikováno v:
Nature chemistry, vol 15, iss 4
Nat Chem
Nat Chem
The Diels-Alder cycloaddition is one of the most powerful approaches in organic synthesis and is often used in the synthesis of important pharmaceuticals. Yet, strictly controlling the stereoselectivity of the Diels-Alder reactions is challenging, an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4ae8a668ab7aa5c190edded534be744
https://doi.org/10.1038/s41557-022-01117-6
https://doi.org/10.1038/s41557-022-01117-6
Autor:
Vikram V. Shende, Natalia R. Harris, Jacob N. Sanders, Sean A. Newmister, Yogan Khatri, Mohammad Movassaghi, Kendall N. Houk, David H. Sherman
Publikováno v:
Angewandte Chemie (International ed. in English).
In the biosynthesis of the tryptophan-linked dimeric diketopiperazines (DKPs), cytochromes P450 selectively couple DKP monomers to generate a variety of intricate and isomeric frameworks. To determine the molecular basis for selectivity of these bioc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65b0c070158731747ee63384f1cc8c4a
https://pubmed.ncbi.nlm.nih.gov/36610039
https://pubmed.ncbi.nlm.nih.gov/36610039
Autor:
Justin Kim, Sean A. Newmister, Mohammad Movassaghi, Tyler J. Doyon, K. N. Houk, Vikram V. Shende, Petra Lindovska, Jacob N. Sanders, Yogan Khatri, Fengan Yu, David H. Sherman
Publikováno v:
J Am Chem Soc
The dimeric diketopiperazine (DKPs) alkaloids are a diverse family of natural products (NPs) whose unique structural architectures and biological activities have inspired the development of new synthetic methodology to access these molecules. However
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c717247ce2d2a8b67ec603f907d00923
https://doi.org/10.1021/jacs.0c06312
https://doi.org/10.1021/jacs.0c06312
Autor:
Shengying Li, Sachiko Tsukamoto, Sean A. Newmister, David H. Sherman, Robert M. Williams, Hong T. Tran, Samantha P. Kelly, Hikaru Kato, Lei Du, Ashootosh Tripathi, Amy E. Fraley
Publikováno v:
Chembiochem
The fungal indole alkaloids are a unique class of complex molecules that have a characteristic bicyclo[2.2.2]diazaoctane ring and frequently contain a spiro-oxindole moiety. While various strains produce these compounds, an intriguing case involves t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62696e54c61bfe3d41c50bcb070e4995
https://doi.org/10.1002/cbic.202000004
https://doi.org/10.1002/cbic.202000004
Autor:
Shasha Li, Sean A. Newmister, Andrew N. Lowell, Jiachen Zi, Callie R. Chappell, Fengan Yu, Robert M. Hohlman, Jimmy Orjala, Robert M. Williams, David H. Sherman
Publikováno v:
Angewandte Chemie. 132:8243-8249
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c167b1f2f9da53ca6242e34c6418a247
https://doi.org/10.1002/ange.201913686
https://doi.org/10.1002/ange.201913686
Autor:
Ying Ye, Kersti Caddell Haatveit, Janet L. Smith, Sean A. Newmister, Robert M. Williams, Samantha P. Kelly, Amy E. Fraley, David H. Sherman, K. N. Houk, Fengan Yu
Publikováno v:
Journal of the American Chemical Society, vol 142, iss 5
J Am Chem Soc
J Am Chem Soc
The paraherquamides are potent anthelmintic natural products with complex heptacyclic scaffolds. One key feature of these molecules is the spiro-oxindole moiety that lends a strained three-dimensional architecture to these structures. The flavin mono
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e731711f0f2bf97d8ee13af929848ae
https://doi.org/10.1021/jacs.9b09070
https://doi.org/10.1021/jacs.9b09070
Autor:
Sean A. Newmister, S. Wald Grossman, Rosa V. Espinoza, John Montgomery, Yogan Khatri, Caylie A. McGlade, David H. Sherman, Marc Garcia-Borràs, Kersti Caddell Haatveit, Jin Yi Tan, K. N. Houk, Jennifer J. Schmidt
Publikováno v:
ACS Catal
ACS catalysis, vol 11, iss 13
ACS catalysis, vol 11, iss 13
Iterative P450 enzymes are powerful biocatalysts for selective late-stage C-H oxidation of complex natural product scaffolds. These enzymes represent new tools for selectivity and cascade reactions, facilitating direct access to core structure divers
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74a5b77bfadbdceadc34c4b2d4af0813
https://europepmc.org/articles/PMC8739753/
https://europepmc.org/articles/PMC8739753/
Autor:
Sean A. Newmister, Yogan Khatri, Robert M. Hohlman, Kendall N. Houk, David H. Sherman, Andrew N. Lowell, Shasha Li, Nikki R. Keramati, Jacob N. Sanders
Publikováno v:
ACS catalysis, vol 11, iss 8
ACS Catal
ACS Catal
Hapalindoles and related compounds (ambiguines, fischerindoles, welwitindolinones) are a diverse class of indole alkaloid natural products. They are typically isolated from the Stigonemataceae order of cyanobacteria and possess a broad scope of biolo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a746262a84047f4382b698f0a0cb5aed
https://escholarship.org/uc/item/1q46f7xd
https://escholarship.org/uc/item/1q46f7xd
Autor:
Sean A. Newmister, Shengying Li, Shuai Mu, Maria L. Adrover-Castellano, Atsushi Minami, Robert S. Paton, Amy E. Fraley, David H. Sherman, Juan V. Alegre-Requena, Xingwang Zhang, Robert M. Williams, Wei Zhang, Nolan Carney, Hideaki Oikawa, Feifei Qi, Hikaru Kato, Ying Ye, Lei Du, Sachiko Tsukamoto, Morgan McCauley, Vikram V. Shende
Publikováno v:
Nat Catal
Fungal bicyclo[2.2.2]diazaoctane indole alkaloids represent an important family of natural products with a wide spectrum of biological activities. Although biomimetic total syntheses of representative compounds have been reported, the details of thei
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d3f7f070ad3996aa80b101a1916a6b2
https://ora.ox.ac.uk/objects/uuid:33ef88b5-8728-48b0-a406-713479debd08
https://ora.ox.ac.uk/objects/uuid:33ef88b5-8728-48b0-a406-713479debd08