Zobrazeno 1 - 10
of 42
pro vyhledávání: '"Sean A. Misek"'
Autor:
Sean A. Misek, Aaron Fultineer, Jeremie Kalfon, Javad Noorbakhsh, Isabella Boyle, Priyanka Roy, Joshua Dempster, Lia Petronio, Katherine Huang, Alham Saadat, Thomas Green, Adam Brown, John G. Doench, David E. Root, James M. McFarland, Rameen Beroukhim, Jesse S. Boehm
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-11 (2024)
Abstract Reducing disparities is vital for equitable access to precision treatments in cancer. Socioenvironmental factors are a major driver of disparities, but differences in genetic variation likely also contribute. The impact of genetic ancestry o
Externí odkaz:
https://doaj.org/article/f5fc9a4be68842a79c2275a29dc90764
Autor:
Sean A. Misek, Bardees M. Foda, Thomas S. Dexheimer, Maisah Akram, Susan E. Conrad, Jens C. Schmidt, Richard R. Neubig, Kathleen A. Gallo
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
Single agent and combination therapy with BRAFV600E/K and MEK inhibitors have remarkable efficacy against melanoma tumors with activating BRAF mutations, but in most cases BRAF inhibitor (BRAFi) resistance eventually develops. One resistance mechanis
Externí odkaz:
https://doaj.org/article/13e3b3bcb52f4731ab7a41e5e5dd7d41
Autor:
Kathleen A. Gallo, Jann N. Sarkaria, Ashley Sample, Chotirat Rattanasinchai, Laura Schroeder, Jian Chen, Sean A. Misek
A hallmark of glioblastoma (GBM) tumors is their highly invasive behavior. Tumor dissemination into surrounding brain tissue is responsible for incomplete surgical resection, and subsequent tumor recurrence. Identification of targets that control GBM
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::eca6295ebcd2a5b1e9658534925cfba6
https://doi.org/10.1158/1541-7786.c.6540109.v1
https://doi.org/10.1158/1541-7786.c.6540109.v1
Autor:
Richard R. Neubig, Elizabeth R. Lawlor, Monique Verhaegen, Scott D. Larsen, Melanie A. Krook, Merlin Airik, Cheryl E. Rockwell, Jessica L. Bell, Susan M. Wade, Yajing Ji, Sean A. Misek, Erika M. Lisabeth, Kathryn M. Appleton, Andrew J. Haak
To show that MRTF-A localization was dependent on F-actin dynamics, we stimulated SK-Mel-19 cells with 20% FBS to induce stress fiber formation which induced MRTF-A nuclear localization. We also treated SK-Mel-147 cells with latrunculin B which inhib
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1117c9e2a1495f7253941a73c0d5452d
https://doi.org/10.1158/1535-7163.22508319
https://doi.org/10.1158/1535-7163.22508319
Autor:
Kathleen A. Gallo, Jann N. Sarkaria, Ashley Sample, Chotirat Rattanasinchai, Laura Schroeder, Jian Chen, Sean A. Misek
The effect of CEP-1347 on glioblastoma cell line viability.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::437508a7cf59649cbe9f5b16cd3c4c6a
https://doi.org/10.1158/1541-7786.22512046
https://doi.org/10.1158/1541-7786.22512046
Autor:
Richard R. Neubig, Elizabeth R. Lawlor, Monique Verhaegen, Scott D. Larsen, Melanie A. Krook, Merlin Airik, Cheryl E. Rockwell, Jessica L. Bell, Susan M. Wade, Yajing Ji, Sean A. Misek, Erika M. Lisabeth, Kathryn M. Appleton, Andrew J. Haak
The Cancer Genome Atlas (TCGA) cutaneous melanoma dataset was stratified into quartiles based upon expression of indicated genes. Kaplan-Meier plots were generated from the highest (grey) and lowest (black) expressing quartiles. Survival curves were
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::412fad174ba69ff2635cf96a88d4e660
https://doi.org/10.1158/1535-7163.22508322.v1
https://doi.org/10.1158/1535-7163.22508322.v1
Autor:
Evgenii Chekalin, Bin Chen, Kathleen A. Gallo, Patrick A. Newbury, Shreya Paithankar, Richard R. Neubig, Sean A. Misek, Andrea I. Doseff
Publikováno v:
Molecular Pharmacology. 101:1-12
Most B-Raf proto-oncogene (BRAF)-mutant melanoma tumors respond initially to BRAF inhibitor (BRAFi)/mitogen-activated protein kinase kinase 1 inhibitor (MEKi) therapy, although few patients have durable long-term responses to these agents. The goal o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd5384dd1695e88dfb134f36cfe76da9
https://doi.org/10.1124/molpharm.121.000331
https://doi.org/10.1124/molpharm.121.000331
Autor:
Sean A. Misek, Aaron Fultineer, Jeremie Kalfon, Javad Noorbakhsh, Isabella Boyle, Joshua Dempster, Lia Petronio, Katherine Huang, Alham Saadat, Thomas Green, Adam Brown, John G. Doench, David Root, James McFarland, Rameen Beroukhim, Jesse S. Boehm
Reducing disparities is critical to promote equity of access to precision treatments for all patients with cancer. While socioenvironmental factors are a major driver behind such disparities, biological differences also are likely to contribute. The
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f0df55af9b2b0a3fe1d1e8632f4f48ec
https://doi.org/10.1101/2022.11.18.517155
https://doi.org/10.1101/2022.11.18.517155
Autor:
Sean Alexander Misek, Aaron Fultineer, Jeremie Kalfon, Javad Noorbakhsh, Isabella Boyle, Joshua Dempster, Lia Petronio, Katherine Huang, James McFarland, Rameen Beroukhim, Jesse Boehm
Publikováno v:
Cancer Research. 82:2173-2173
Socioeconomic factors and discrimination play major roles in variable cancer treatment outcomes across individuals from different ancestral backgrounds. Tumors from patients of different ancestry groups also have divergent patterns of somatic and ger
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::41a4a8dbb1e6c8eed5b30bc5a86e4194
https://doi.org/10.1158/1538-7445.am2022-2173
https://doi.org/10.1158/1538-7445.am2022-2173
Autor:
Erika M. Lisabeth, Dylan Kahl, Indiwari Gopallawa, Sarah E. Haynes, Sean A. Misek, Phillip L. Campbell, Thomas S. Dexheimer, Dinesh Khanna, David A. Fox, Xiangshu Jin, Brent R. Martin, Scott D. Larsen, Richard R. Neubig
Publikováno v:
ACS Pharmacology & Translational Science. 2:92-100
A series of compounds (including CCG-1423 and CCG-203971) discovered through an MRTF/SRF-dependent luciferase screen has shown remarkable efficacy in a variety of in vitro and in vivo models, including significant reduction of melanoma metastasis and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e04156d0c2d45fc9015adba97c002eb
https://doi.org/10.1021/acsptsci.8b00048
https://doi.org/10.1021/acsptsci.8b00048