Zobrazeno 1 - 10
of 84
pro vyhledávání: '"Sean A. Cullen"'
Autor:
Raghav Ramabadran, Jarey H. Wang, Jaime M. Reyes, Anna G. Guzman, Sinjini Gupta, Carina Rosas, Lorenzo Brunetti, Michael C. Gundry, Ayala Tovy, Hali Long, Tianpeng Gu, Sean M. Cullen, Siddhartha Tyagi, Danielle Rux, Jean J. Kim, Steven M. Kornblau, Michael Kyba, Fabio Stossi, Rachel E. Rau, Koichi Takahashi, Thomas F. Westbrook, Margaret A. Goodell
Publikováno v:
Nature Cell Biology. 25:528-539
Autor:
Tianpeng Gu, Xueqiu Lin, Sean M. Cullen, Min Luo, Mira Jeong, Marcos Estecio, Jianjun Shen, Swanand Hardikar, Deqiang Sun, Jianzhong Su, Danielle Rux, Anna Guzman, Minjung Lee, Lei Stanley Qi, Jia-Jia Chen, Michael Kyba, Yun Huang, Taiping Chen, Wei Li, Margaret A. Goodell
Publikováno v:
Genome Biology, Vol 19, Iss 1, Pp 1-15 (2018)
Abstract Background DNA methylation is a heritable epigenetic mark, enabling stable but reversible gene repression. In mammalian cells, DNA methyltransferases (DNMTs) are responsible for modifying cytosine to 5-methylcytosine (5mC), which can be furt
Externí odkaz:
https://doaj.org/article/6fd2d3e46453433ea4d4e102f933e748
Autor:
Susana L. Orozco, Brian P. Daniels, Nader Yatim, Michelle N. Messmer, Giovanni Quarato, Haiyin Chen-Harris, Sean P. Cullen, Annelise G. Snyder, Pooja Ralli-Jain, Sharon Frase, Stephen W.G. Tait, Douglas R. Green, Matthew L. Albert, Andrew Oberst
Publikováno v:
Cell Reports, Vol 28, Iss 9, Pp 2275-2287.e5 (2019)
Summary: Necroptosis is a form of programmed cell death that is defined by activation of the kinase RIPK3 and subsequent cell membrane permeabilization by the effector MLKL. RIPK3 activation can also promote immune responses via production of cytokin
Externí odkaz:
https://doaj.org/article/7ffc260e505644a99f8c4f409cad4f57
Autor:
Chongyuan Luo, Qian Yi Lee, Orly Wapinski, Rosa Castanon, Joseph R Nery, Moritz Mall, Michael S Kareta, Sean M Cullen, Margaret A Goodell, Howard Y Chang, Marius Wernig, Joseph R Ecker
Publikováno v:
eLife, Vol 8 (2019)
Direct reprogramming of fibroblasts to neurons induces widespread cellular and transcriptional reconfiguration. Here, we characterized global epigenomic changes during the direct reprogramming of mouse fibroblasts to neurons using whole-genome base-r
Externí odkaz:
https://doaj.org/article/9ddb88e6e2a54fc28cfcbc1f3cab0113
Publikováno v:
Cell Reports, Vol 11, Iss 10, Pp 1535-1548 (2015)
The NLRP3 inflammasome is involved in caspase-1-dependent maturation of IL-1β in many contexts. A two-signal model has emerged for IL-1β maturation, with LPS providing “signal I” and diverse agents such as ATP, Nigericin, streptolysin O, uric a
Externí odkaz:
https://doaj.org/article/e5e0a8b11f5141f7bb64529a0f5a3077
Publikováno v:
Biology of Reproduction. 105:747-760
It is well established that environmental exposures can modify the profile of heritable factors in an individual's germ cells, ultimately affecting the inheritance of phenotypes in descendants. Similar to exposures, an ancestor's genotype can also af
Publikováno v:
Pediatrics. 150
OBJECTIVES Liquid medication dosing errors are common in pediatrics. Our outpatient clinic identified gaps in caregiver education based on a 2015 American Academy of Pediatrics policy statement on prescribing liquid medications. This quality improvem
Autor:
Alexander C. Flint, Carol Conell, Jeff G. Klingman, Vivek A. Rao, Sheila L. Chan, Hooman Kamel, Sean P. Cullen, Bonnie S. Faigeles, Steve Sidney, S. Claiborne Johnston
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 5, Iss 8 (2016)
BackgroundStatin administration early in ischemic stroke may influence outcomes. Our aim was to determine the clinical impact of increasing statin administration early in ischemic stroke hospitalization. Methods and ResultsThis is a retrospective ana
Externí odkaz:
https://doaj.org/article/aae9254edbd341acb7bf7fde882ef1b5
Autor:
Daniel P. Hsu, Prasad A. Reddy, Vivek A. Rao, Sean P. Cullen, Abigail Eaton, Jonathan Hartman, Nancy J. Edwards, Jeffrey Klingman, Alexander C. Flint, Mai N. Nguyen-Huynh, Stephen Uong, Patricia A Zrelak, Andrew L. Avins, Sheila L. Chan
Publikováno v:
Stroke. 51:2697-2704
Background and Purpose: In large artery occlusion stroke, both intravenous (IV) tPA (tissue-type plasminogen activator) and endovascular stroke treatment (EST) are standard-of-care. It is unknown how often tPA causes distal embolization, in which a p
Autor:
Michael A. Carpenter, Zhouying Zhao, Nicole M. Briglio, Harold J. Hoops, Matthew Kowalik, Sean P. Cullen, Hyunah Cho, Kazushige Yokoyama
Publikováno v:
International Journal of Molecular Sciences, Vol 10, Iss 5, Pp 2348-2366 (2009)
Aβ1-40 coated 20 nm gold colloidal nanoparticles exhibit a reversible color change as pH is externally altered between pH 4 and 10. This reversible process may contain important information on the initial reversible step reported for the fibrillogen
Externí odkaz:
https://doaj.org/article/0bf28b0306404a78bd0c4d4933cd6707