Zobrazeno 1 - 10
of 239
pro vyhledávání: '"Sean A McKenna"'
Autor:
Edis Dzananovic, Astha, Grzegorz Chojnowski, Soumya Deo, Evan P Booy, Pauline Padilla-Meier, Kevin McEleney, Janusz M Bujnicki, Trushar R Patel, Sean A McKenna
Publikováno v:
PLoS ONE, Vol 12, Iss 10, p e0186849 (2017)
Highly structured RNA derived from viral genomes is a key cellular indicator of viral infection. In response, cells produce the interferon inducible RNA-dependent protein kinase (PKR) that, when bound to viral dsRNA, phosphorylates eukaryotic initiat
Externí odkaz:
https://doaj.org/article/84fd847862b04e2c823b1f4366e567eb
Autor:
Emmanuel O Ariyo, Evan P Booy, Trushar R Patel, Edis Dzananovic, Ewan K McRae, Markus Meier, Kevin McEleney, Jorg Stetefeld, Sean A McKenna
Publikováno v:
PLoS ONE, Vol 10, Iss 12, p e0144510 (2015)
Nucleic acids rich in guanine are able to fold into unique structures known as G-quadruplexes. G-quadruplexes consist of four tracts of guanylates arranged in parallel or antiparallel strands that are aligned in stacked G-quartet planes. The structur
Externí odkaz:
https://doaj.org/article/09bafcf3bcda4fa283619b50b11332a5
Autor:
Soumya Deo, Trushar R Patel, Edis Dzananovic, Evan P Booy, Khalid Zeid, Kevin McEleney, Stephen E Harding, Sean A McKenna
Publikováno v:
PLoS ONE, Vol 9, Iss 3, p e92545 (2014)
West Nile virus (WNV) has a positive sense RNA genome with conserved structural elements in the 5' and 3' -untranslated regions required for polyprotein production. Antiviral immunity to WNV is partially mediated through the production of a cluster o
Externí odkaz:
https://doaj.org/article/c340459956e04d00b0b3f472c7a1ecaf
Publikováno v:
AIMS Mathematics, Vol 6, Iss 6, Pp 5924-5941 (2021)
The activation of 2'-5'-oligoadenylate synthetase (OAS) enzymes by direct interaction with viral double-stranded RNA (dsRNA) is a key part of the innate immune response to viral infection. A downstream effect of the OAS-dsRNA interaction is to degrad
Externí odkaz:
https://doaj.org/article/5f3765fce04c4fca89c3112669a1e913
Autor:
Thomas C. Chamberlain, Sylvia T. Cheung, Jeff S.J. Yoon, Andrew Ming-Lum, Bernd R. Gardill, Soroush Shakibakho, Edis Dzananovic, Fuqiang Ban, Abrar Samiea, Kamaldeep Jawanda, John Priatel, Gerald Krystal, Christopher J. Ong, Artem Cherkasov, Raymond J. Andersen, Sean A. McKenna, Filip Van Petegem, Alice L-F. Mui
Publikováno v:
iScience, Vol 23, Iss 8, Pp 101433- (2020)
Summary: The anti-inflammatory actions of interleukin-10 (IL10) are thought to be mediated primarily by the STAT3 transcription factor, but pro-inflammatory cytokines such as interleukin-6 (IL6) also act through STAT3. We now report that IL10, but no
Externí odkaz:
https://doaj.org/article/6d1dc8ece1fe49e58498e3b24c40bfc5
Advances in wildfire modeling have focused on refining atmospheric interactions for obvious links between local airflows, combustion dynamics, fire line advance and smoke plume transport. Yet, lasting impacts of wildfires on landscapes are linked pri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e17cbac91212697e52fa1ef05a9a3193
https://doi.org/10.5194/egusphere-egu23-10389
https://doi.org/10.5194/egusphere-egu23-10389
Publikováno v:
ACS Chemical Biology
Over the past two decades, activity-based probes have enabled a range of discoveries, including the characterization of new enzymes and drug targets. However, their suitability in some labeling experiments can be limited by nonspecific reactivity, po
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5f147067d28c7fa333076982f2bbe9e
http://europepmc.org/articles/PMC8689647
http://europepmc.org/articles/PMC8689647
Autor:
Sean A. McKenna, Daniel Gussakovsky
Publikováno v:
RNA Biol
Alu RNA are implicated in the poor prognosis of several human disease states. These RNA are transcription products of primate specific transposable elements called Alu elements. These elements are extremely abundant, comprising over 10% of the human
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24a1fabc45c8eb3bf22460f2647c6ea0
https://doi.org/10.1080/15476286.2021.1989201
https://doi.org/10.1080/15476286.2021.1989201
Publikováno v:
Journal of Nucleic Acids, Vol 2017 (2017)
Guanine quadruplexes (G4s) are four-stranded secondary structures of nucleic acids which are stabilized by noncanonical hydrogen bonding systems between the nitrogenous bases as well as extensive base stacking, or pi-pi, interactions. Formation of th
Externí odkaz:
https://doaj.org/article/662a9fbabf7b4efc8bedde280078f228