Zobrazeno 1 - 10
of 580
pro vyhledávání: '"Sean, Murphy"'
Protocol for quantifying stem-cell-derived cardiomyocyte maturity using transcriptomic entropy score
Publikováno v:
STAR Protocols, Vol 5, Iss 2, Pp 103083- (2024)
Summary: The inability to quantify cardiomyocyte (CM) maturation remains a significant barrier to evaluating the effects of ongoing efforts to produce adult-like CMs from pluripotent stem cells (PSCs). Here, we present a protocol to quantify stem-cel
Externí odkaz:
https://doaj.org/article/9ec055b7fb8e4258817b1af75cbb551f
Autor:
James H. Schofield, Joseph Longo, Ryan D. Sheldon, Emma Albano, Abigail E. Ellis, Mark A. Hawk, Sean Murphy, Loan Duong, Sharif Rahmy, Xin Lu, Russell G. Jones, Zachary T. Schafer
Publikováno v:
Cell Reports, Vol 43, Iss 4, Pp 113984- (2024)
Summary: Targeting programmed cell death protein 1 (PD-1) is an important component of many immune checkpoint blockade (ICB) therapeutic approaches. However, ICB is not an efficacious strategy in a variety of cancer types, in part due to immunosuppre
Externí odkaz:
https://doaj.org/article/4c7f2836a59b4a5691fa9a3f93e654d9
Autor:
Maria A. Missinato, Sean Murphy, Michaela Lynott, Michael S. Yu, Anaïs Kervadec, Yu-Ling Chang, Suraj Kannan, Mafalda Loreti, Christopher Lee, Prashila Amatya, Hiroshi Tanaka, Chun-Teng Huang, Pier Lorenzo Puri, Chulan Kwon, Peter D. Adams, Li Qian, Alessandra Sacco, Peter Andersen, Alexandre R. Colas
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)
Transdifferentiation has been proposed as an approach for regenerative medicine, but the mechanisms that safeguard cell identity are not well established. Here they identify transcription factors that oppose transdifferentiation and show that knockdo
Externí odkaz:
https://doaj.org/article/20fe073154364337abcffbba8fef58fe
Autor:
Emily Neu, Cora Sears, Timothy Brandon, Melanie Kohlheim, Jenny Leal, Kweli Archie, English Holland, Miles Holland, Aamena Hameed, Asad Khan, Lynn Murphy, Sean Murphy, Antoinette Neu, Jerome Neu, Justin Neu, Rachel Richmond, Dylan Suplee, Theresa Suplee, Christopher B. Forrest, Pamela F. Weiss
Publikováno v:
Health Expectations, Vol 26, Iss 1, Pp 290-296 (2023)
Abstract Background The Biologic Abatement and Capturing Kids’ Outcomes and Flare Frequency in Juvenile Spondyloarthritis (BACK‐OFF JSpA) study is a randomized, pragmatic trial investigating different tumour necrosis factor inhibitor de‐escalat
Externí odkaz:
https://doaj.org/article/9a741fbfd6f645b48acb5f4ebe14e8e3
Autor:
Reza Mohebi, Sean Murphy, Laurel Jackson, Cian McCarthy, Andrew Abboud, Gillian Murtagh, Susan Gawel, Hannah Miksenas, Hanna Gaggin, James L. Januzzi Jr
Publikováno v:
ESC Heart Failure, Vol 9, Iss 6, Pp 3876-3887 (2022)
Abstract Aim The Universal Definition of Heart Failure (UDHF) provides a framework for staging risk for HF events. It is not clear whether prognostic biomarkers have different meaning across UDHF stages. We sought to evaluate performance of biomarker
Externí odkaz:
https://doaj.org/article/9cb368b32ea640adbfe241ac6e5ebdef
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-9 (2022)
Abstract Robotic-assisted gait training (RAGT) devices allow intensive high repetition of the gait cycle in individuals with locomotor disability, with reduced therapist effort. In addition to usual rehabilitation, RAGT post-stroke improves the likel
Externí odkaz:
https://doaj.org/article/4253a8507e0549e5888f040a9da8feff
Autor:
Fiona J. Desmond, MB BCh, BAO, Alina Buture, MD, PhD, Eoin C. Kavanagh, FFR, RCSI, Sean Murphy, MD, FRCPI
Publikováno v:
Radiology Case Reports, Vol 17, Iss 9, Pp 3370-3372 (2022)
Neurofibromatosis type 1 is an autosomal dominant genetic disorder with multisystem manifestations including vascular abnormalities. The condition is also associated with an increased risk of both ischemic and hemorrhagic stroke. Here we report a cas
Externí odkaz:
https://doaj.org/article/de1df93217f74f2e8c435beb47e21292
Autor:
Caitlyn B. Dagenet, Mitchell S. Davis, Sean Murphy, Rebecca Thiede, Keliegh S. Culpepper, Mohammad Fazel
Publikováno v:
Emerging Infectious Diseases, Vol 29, Iss 6, Pp 1268-1269 (2023)
We report a 34-year-old man who had a nonhealing, verrucous plaque with central ulceration on the lower leg. This case-patient is a rare example of endemic limited cutaneous leishmaniasis in Tucson, Arizona, USA. Clinicians should be aware of this di
Externí odkaz:
https://doaj.org/article/b7c6d0586501427ab49aadab84764fe0
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Response resistance to the immune checkpoint blockade (ICB) immunotherapy remains a major clinical challenge that may be overcome through the rational combination of ICB and specific targeted therapeutics. One emerging combination strategy is based o
Externí odkaz:
https://doaj.org/article/6beeabc616a9462799decbd31aa4768c
Publikováno v:
3D Printing in Medicine, Vol 6, Iss 1, Pp 1-10 (2020)
Abstract Background Failure rates with cranioplasty procedures have driven efforts to improve graft material and reduce reoperation. One promising allograft source is a 3D-printed titanium mesh with calcium phosphate filler. This study evaluated fail
Externí odkaz:
https://doaj.org/article/166b8fd6815942d9b95a734dc6727b6a