Zobrazeno 1 - 10 of 523 pro vyhledávání: '"Sean, Ekins"'
2
Akademický článek
The Goldilocks paradigm: comparing classical machine learning, large language models, and few-shot learning for drug discovery applications
Autor: Scott H. Snyder, Patricia A. Vignaux, Mustafa Kemal Ozalp, Jacob Gerlach, Ana C. Puhl, Thomas R. Lane, John Corbett, Fabio Urbina, Sean Ekins
Publikováno v: Communications Chemistry, Vol 7, Iss 1, Pp 1-11 (2024)
Abstract Recent advances in machine learning (ML) have led to newer model architectures including transformers (large language models, LLMs) showing state of the art results in text generation and image analysis as well as few-shot learning (FSLC) mo
Externí odkaz: https://doaj.org/article/35dfdbecd04240859dca01d619069e05
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6
Akademický článek
The commoditization of AI for molecule design
Autor: Fabio Urbina, Sean Ekins
Publikováno v: Artificial Intelligence in the Life Sciences, Vol 2, Iss , Pp 100031- (2022)
Anyone involved in designing or finding molecules in the life sciences over the past few years has witnessed a dramatic change in how we now work due to the COVID-19 pandemic. Computational technologies like artificial intelligence (AI) seemed to bec
Externí odkaz: https://doaj.org/article/97f4cd6346954701902e9d0a985f80a8
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7
Akademický článek
Cross-species efficacy of enzyme replacement therapy for CLN1 disease in mice and sheep
Autor: Hemanth R. Nelvagal, Samantha L. Eaton, Sophie H. Wang, Elizabeth M. Eultgen, Keigo Takahashi, Steven Q. Le, Rachel Nesbitt, Joshua T. Dearborn, Nicholas Siano, Ana C. Puhl, Patricia I. Dickson, Gerard Thompson, Fraser Murdoch, Paul M. Brennan, Mark Gray, Stephen N. Greenhalgh, Peter Tennant, Rachael Gregson, Eddie Clutton, James Nixon, Chris Proudfoot, Stefano Guido, Simon G. Lillico, C. Bruce A. Whitelaw, Jui-Yun Lu, Sandra L. Hofmann, Sean Ekins, Mark S. Sands, Thomas M. Wishart, Jonathan D. Cooper
Publikováno v: The Journal of Clinical Investigation, Vol 132, Iss 20 (2022)
CLN1 disease, also called infantile neuronal ceroid lipofuscinosis (NCL) or infantile Batten disease, is a fatal neurodegenerative lysosomal storage disorder resulting from mutations in the CLN1 gene encoding the soluble lysosomal enzyme palmitoyl-pr
Externí odkaz: https://doaj.org/article/fb7adb2cd6174d5a9c38555ece25def7
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8
Akademický článek
Machine Learning for Discovery of New ADORA Modulators
Autor: Ana C. Puhl, Zhan-Guo Gao, Kenneth A. Jacobson, Sean Ekins
Publikováno v: Frontiers in Pharmacology, Vol 13 (2022)
Adenosine (ADO) is an extracellular signaling molecule generated locally under conditions that produce ischemia, hypoxia, or inflammation. It is involved in modulating a range of physiological functions throughout the brain and periphery through the
Externí odkaz: https://doaj.org/article/2ef52e64f0274162a77eb5e38d30693e
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10
Akademický článek
Targeted Metabolomics of Organophosphate Pesticides and Chemical Warfare Nerve Agent Simulants Using High- and Low-Dose Exposure in Human Liver Microsomes
Autor: Garima Agarwal, Hunter Tichenor, Sarah Roo, Thomas R. Lane, Sean Ekins, Craig A. McElroy
Publikováno v: Metabolites, Vol 13, Iss 4, p 495 (2023)
Our current understanding of organophosphorus agent (pesticides and chemical warfare nerve agents) metabolism in humans is limited to the general transformation by cytochrome P450 enzymes and, to some extent, by esterases and paraoxonases. The role o
Externí odkaz: https://doaj.org/article/51bac74715764d14bcff64f20e9d181e
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