Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Sean, Coakley"'
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Neurons are subjected to strains due to body movements and their locations within organs and tissues. Here the authors show that UNC-70/β-spectrin and TBC-10 dynamically maintain attachment of the axon within the epidermis non-cell-autonomously by s
Externí odkaz:
https://doaj.org/article/7988a664ddb54a37b81626780cf423c1
Publikováno v:
Cell Reports, Vol 38, Iss 10, Pp 110501- (2022)
Summary: Axons experience significant strain caused by organismal development and movement. A combination of intrinsic mechanical resistance and external shielding by surrounding tissues prevents axonal damage, although the precise mechanisms are unk
Externí odkaz:
https://doaj.org/article/c62e9d7097c64402b72cb04af87f48f3
Autor:
Sarah-Lena Offenburger, Xue Yan Ho, Theresa Tachie-Menson, Sean Coakley, Massimo A Hilliard, Anton Gartner
Publikováno v:
PLoS Genetics, Vol 14, Iss 1, p e1007125 (2018)
Oxidative stress is linked to many pathological conditions including the loss of dopaminergic neurons in Parkinson's disease. The vast majority of disease cases appear to be caused by a combination of genetic mutations and environmental factors. We s
Externí odkaz:
https://doaj.org/article/ba08b8cd90554533b7a794bca251dbaf
Spectrins are highly conserved molecules that form a distinct membrane associated periodic scaffold within axons thought to provide mechanical resilience. In C. elegans, UNC-70/ß-Spectrin also functions outside the nervous system, within the epiderm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f73e2909db8f77b467b0b744c6f4aada
https://doi.org/10.1101/2022.09.07.507048
https://doi.org/10.1101/2022.09.07.507048
Autor:
Daniel C. Williams, Rachid El Bejjani, Paula Mugno Ramirez, Sean Coakley, Shin Ae Kim, Hyewon Lee, Quan Wen, Aravi Samuel, Hang Lu, Massimo A. Hilliard, Marc Hammarlund
Publikováno v:
Cell Reports, Vol 5, Iss 2, Pp 553-563 (2013)
Inactivation of selected neurons in vivo can define their contribution to specific developmental outcomes, circuit functions, and behaviors. Here, we show that the optogenetic tool KillerRed selectively, rapidly, and permanently inactivates different
Externí odkaz:
https://doaj.org/article/f775bce7746240f584e4de4528b7ab6b
Autor:
Michele Bastiani, Harriet P. Lo, Jan Steyaert, Rachel S. Gormal, Els Pardon, Merja Joensuu, Srikanth Budnar, Adekunle T. Bademosi, James Rae, Ailisa Blum, Jean Giacomotto, Pranesh Padmanabhan, Frederic A. Meunier, Geoffrey J. Goodhill, Alpha S. Yap, Tristan P. Wallis, Massimo A. Hilliard, Walter G. Thomas, Ravikiran Kasula, Robert G. Parton, Charles Ferguson, Sean Coakley
Publikováno v:
Proc Natl Acad Sci U S A
None of the current superresolution microscopy techniques can reliably image the changes in endogenous protein nanoclustering dynamics associated with specific conformations in live cells. Single-domain nanobodies have been invaluable tools to isolat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d015bc888a680e98a149ee7b2bbde934
https://doi.org/10.1073/pnas.2007443117
https://doi.org/10.1073/pnas.2007443117
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Nature Communications
Nature Communications
Neurons are subjected to strain due to body movement and their location within organs and tissues. However, how they withstand these forces over the lifetime of an organism is still poorly understood. Here, focusing on touch receptor neuron-epidermis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fcec4c598363cdef988003736339c8ab
http://link.springer.com/article/10.1038/s41467-019-13795-x
http://link.springer.com/article/10.1038/s41467-019-13795-x
Publikováno v:
Science advances. 8(11)
Axonal fusion is an efficient means of repair following axonal transection, whereby the regenerating axon fuses with its own separated axonal fragment to restore neuronal function. Despite being described over 50 years ago, its molecular mechanisms r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3314a3439eee485af500e3ed9034bbd6
https://pubmed.ncbi.nlm.nih.gov/35294233
https://pubmed.ncbi.nlm.nih.gov/35294233
SummaryLigand-receptor interactions guide axon navigation and dendrite arborization. Mechanical forces also influence guidance choices. However, the nature of such mechanical stimulations, the mechanosensors identity and how they interact with guidan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::acc7ab242127714fd59a932d2fda1c00
https://doi.org/10.1101/2022.02.28.482179
https://doi.org/10.1101/2022.02.28.482179
Publikováno v:
Developmental Cell. 57:1615-1629.e3
Ligand-receptor interactions guide axon navigation and dendrite arborization. Mechanical forces also influence guidance choices. However, the nature of such mechanical stimulations, the mechanosensor identity, and how they interact with guidance rece
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c291b6d6d4923d7025207b7e90b24d75
https://doi.org/10.1016/j.devcel.2022.05.019
https://doi.org/10.1016/j.devcel.2022.05.019