Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Sean, Bickerton"'
Autor:
David A. Horwitz, Ju Hua Wang, Dongin Kim, Chang Kang, Katja Brion, Sean Bickerton, Antonio La Cava
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
We have previously reported that nanoparticles (NPs) loaded with IL-2 and TGF-β and targeted to T cells induced polyclonal T regulatory cells (Tregs) that protected mice from graft-versus-host disease (GvHD). Here, we evaluated whether administratio
Externí odkaz:
https://doaj.org/article/bf7e97bd85f64b0fbcc7aa4e6dd95d31
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Autoimmune diseases are disorders of immune regulation where the mechanisms responsible for self-tolerance break down and pathologic T cells overcome the protective effects of T regulatory cells (Tregs) that normally control them. The result can be t
Externí odkaz:
https://doaj.org/article/6a1d8257bc864a58b3c6a1d896a9b349
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Artificial antigen-presenting cells (aAPCs) are synthetic versions of naturally occurring antigen-presenting cells (APCs) that, similar to natural APCs, promote efficient T effector cell responses in vitro. This report describes a method to produce a
Externí odkaz:
https://doaj.org/article/0ad6ba1b3edd48918e35a0b2146603c8
Autor:
Raul de la Flor, Janette Robertson, Rostislav V. Shevchenko, Mo Alavijeh, Sean Bickerton, Tarek Fahmy, Su M. Metcalfe
Publikováno v:
Frontiers in Medical Technology, Vol 3 (2021)
Multiple sclerosis (MS) is a demyelinating autoimmune disease that attacks the brain, with year-on-year loss of brain volume, starting late teens and becoming manifest late twenties. There is no cure, and current therapies are immunosuppressive only.
Externí odkaz:
https://doaj.org/article/9f50990e73424ad8a542664ee3dc40ce
Autor:
David A. Horwitz, Aijing Liu, Sean Bickerton, Giuseppe Castaldo, Giuseppe Matarese, Tarek M. Fahmy, Antonio La Cava
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
We recently reported that the treatment with nanoparticles (NPs) loaded with tolerogenic cytokines suppressed the manifestations of lupus-like disease induced by the transfer of donor CD4+ T cells from DBA/2 mice into (C57BL/6 × DBA/2)F1 (BDF1) mice
Externí odkaz:
https://doaj.org/article/8c0395ecdfc14b81aad71aee7f2c88ad
Autor:
Michael D McHugh, Tarek M. Fahmy, Sean Bickerton, Jung Seok Lee, Ragy Ragheb, Rabib Chaudhury, David A. Horwitz, Shihan N. Khan, Alyssa Siefert, Robert M. Samstein, Karlo Perica, José M. Carballido, Gerald Rea, Dongin Kim, Hyun Bong Park, Jason M. Criscione, Patrick Han
Publikováno v:
Nature Biomedical Engineering. 5:983-997
Oral formulations of insulin are typically designed to improve its intestinal absorption and increase its blood bioavailability. Here we show that polymerized ursodeoxycholic acid, selected from a panel of bile-acid polymers and formulated into nanop
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d9a9924906a6b2c094f9e6b9f00d953a
https://doi.org/10.1038/s41551-021-00791-0
https://doi.org/10.1038/s41551-021-00791-0
Publikováno v:
Rheumatology and immunology research. 2(3)
We recently reported that poly lactic-co-glycolic acid (PLGA) nanoparticles (NPs) loaded with interleukin (IL)-2 and targeted to T cells inhibited the development of lupus-like disease in BDF1 mice by inducing functional T regulatory cells (Tregs). H
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7072116bedfb5e0441d69d7a2bc8c161
https://pubmed.ncbi.nlm.nih.gov/36465067
https://pubmed.ncbi.nlm.nih.gov/36465067
Publikováno v:
Arthritis & Rheumatology. 71:632-640
Objective To develop a nanoparticle (NP) platform that can expand both CD4+ and CD8+ Treg cells in vivo for the suppression of autoimmune responses in systemic lupus erythematosus (SLE). Methods Poly(lactic-co-glycolic acid) (PLGA) NPs encapsulating
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2c17c1281f6c6a7b112318def3be5199
https://doi.org/10.1002/art.40773
https://doi.org/10.1002/art.40773
Autor:
Rabib Chaudhury, Brenda M. Calderon, Jung Seok Lee, Sean Bickerton, Anjelica L. Gonzalez, Patrick Han, Amanda S. Pellowe, Shihan N. Khan, Tarek M. Fahmy
Publikováno v:
Molecular pharmaceutics. 18(3)
Targeting different cell surface receptors with nanoparticle (NP)-based platforms can result in differential particle binding properties that may impact their localization, bioavailability, and, ultimately, the therapeutic efficacy of an encapsulated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ecf252ea9576de180048b033ff0b577e
https://pubmed.ncbi.nlm.nih.gov/33428414
https://pubmed.ncbi.nlm.nih.gov/33428414
Autor:
Raul de la Flor, Janette Robertson, Mo Alavijeh, Tarek M. Fahmy, Sean Bickerton, Su M. Metcalfe, Rostislav V. Shevchenko
Publikováno v:
Frontiers in Medical Technology
Frontiers in Medical Technology, Vol 3 (2021)
Frontiers in Medical Technology, Vol 3 (2021)
Multiple sclerosis (MS) is a demyelinating autoimmune disease that attacks the brain, with year-on-year loss of brain volume, starting late teens and becoming manifest late twenties. There is no cure, and current therapies are immunosuppressive only.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::886435843d2b7ca9cd69c5ecf7127525
https://pubmed.ncbi.nlm.nih.gov/35047909
https://pubmed.ncbi.nlm.nih.gov/35047909