Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Seamus Morrone"'
Autor:
Ahmed Rattani, Magda Wolna, Mickael Ploquin, Wolfgang Helmhart, Seamus Morrone, Bernd Mayer, Jonathan Godwin, Wenqing Xu, Olaf Stemmann, Alberto Pendas, Kim Nasmyth
Publikováno v:
eLife, Vol 2 (2013)
Accurate chromosome segregation depends on coordination between cohesion resolution and kinetochore-microtubule interactions (K-fibers), a process regulated by the spindle assembly checkpoint (SAC). How these diverse processes are coordinated remains
Externí odkaz:
https://doaj.org/article/11dc95a63a414f9bb3691f0ebfc5f096
Publikováno v:
PLoS Biology, Vol 5, Iss 8, p e202 (2007)
The SV40 small t antigen (ST) is a potent oncoprotein that perturbs the function of protein phosphatase 2A (PP2A). ST directly interacts with the PP2A scaffolding A subunit and alters PP2A activity by displacing regulatory B subunits from the A subun
Externí odkaz:
https://doaj.org/article/2238af8dbb164c6bb2cc9c486ff7c6d9
Publikováno v:
Proceedings of the National Academy of Sciences. 115
The AIM2-ASC inflammasome is a filamentous signaling platform essential for mounting host defense against cytoplasmic dsDNA arising not only from invading pathogens but also from damaged organelles. Currently, the design principles of its underlying
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03cb8500ce83adeec22d0b07f1cbfbbe
https://doi.org/10.1073/pnas.1712860115
https://doi.org/10.1073/pnas.1712860115
Autor:
Seamus Morrone, Walter F. Mangel, Andrew Robinson, Antoine M. van Oijen, Aartje C. Schulte, Jungsan Sohn, Lisanne M. Spenkelink, William J. McGrath, Hylkje Geertsema
Publikováno v:
Biophysical Journal. 108(4):949-956
Single-molecule fluorescence microscopy is a powerful tool for observing biomolecular interactions with high spatial and temporal resolution. Detecting fluorescent signals from individual labeled proteins above high levels of background fluorescence
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6c58ed18b41738c0ffdaed09eee7f9f
Publikováno v:
eLife, Vol 4 (2015)
eLife
eLife, 4, 1-13. ELIFE SCIENCES PUBLICATIONS LTD
eLife
eLife, 4, 1-13. ELIFE SCIENCES PUBLICATIONS LTD
The ability to recognize foreign double-stranded (ds)DNA of pathogenic origin in the intracellular environment is an essential defense mechanism of the human innate immune system. However, the molecular mechanisms underlying distinction between forei
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca8fe13ea09d948b2d21b1d821cee4b7
https://doi.org/10.7554/elife.11721
https://doi.org/10.7554/elife.11721
Autor:
Ashok Kumar Patel, Jeffrey N. McKnight, Gregory D. Bowman, Srinivas Chakravarthy, Seamus Morrone, Ilana M. Nodelman
Publikováno v:
Nucleic Acids Research
Chromatin remodelers can either organize or disrupt nucleosomal arrays, yet the mechanisms specifying these opposing actions are not clear. Here, we show that the outcome of nucleosome sliding by Chd1 changes dramatically depending on how the chromat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76cc26ddbeb45a83cefb6d818a607d06
https://doi.org/10.1093/nar/gks1440
https://doi.org/10.1093/nar/gks1440
Autor:
Randall T. Moon, Liguo Wang, Zhihong Cheng, Travis L. Biechele, Wenqing Xu, Zhiyi Wei, Seamus Morrone
Publikováno v:
Nature Structural & Molecular Biology. 18:1204-1210
Low-density-lipoprotein (LDL) receptor-related proteins 5 and 6 (LRP5/6) are Wnt co-receptors essential for Wnt/β-catenin signaling. Dickkopf 1 (DKK1) inhibits Wnt signaling by interacting with the extracellular domains of LRP5/6 and is a drug targe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ecf0f778f0ccb24845e9d4fd86b282fb
https://doi.org/10.1038/nsmb.2139
https://doi.org/10.1038/nsmb.2139
Autor:
Xiong Yu, Michael Delannoy, Mariusz Matyszewski, Edward H. Egelman, Seamus Morrone, Jungsan Sohn
Publikováno v:
Nature Communications
AIM2 recognizes foreign dsDNA and assembles into the inflammasome, a filamentous supramolecular signalling platform required to launch innate immune responses. We show here that the pyrin domain of AIM2 (AIM2PYD) drives both filament formation and ds
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed122af4ea8bdf72f25aec467ba4fd87
https://doi.org/10.1038/ncomms8827
https://doi.org/10.1038/ncomms8827
Publikováno v:
Biophysical Journal. 108(2)
AIM2-Like Receptors (ALRs) are a class of innate immune receptors for foreign DNA, members of which exist in both the cytosol and nucleus. The eponymous member of this family, AIM2, is a cytosolic DNA sensor composed of an N-terminal pyrin domain (PY
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::993bccbb8d8d3a5d21c8df2934d5de86