Targeting rapid TKI-induced AXL upregulation overcomes adaptive ERK reactivation and exerts antileukemic effects in FLT3/ITD acute myeloid leukemia.

Autor: Seale TS; Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Li L; Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Bruner JK; Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Chou M; Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Nguyen B; Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Seo J; Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Zhu R; Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Levis MJ; Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Pratilas CA; Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.; Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Small D; Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.; Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

Publikováno v: Molecular oncology [Mol Oncol] 2024 Oct 12. Date of Electronic Publication: 2024 Oct 12.