Zobrazeno 1 - 10
of 727
pro vyhledávání: '"Seah H"'
Publikováno v:
Hematology, Vol 29, Iss 1 (2024)
ABSTRACTBackground Endari (L-glutamine) is a conditional amino acid that reduces the frequency of vaso-occlusive crisis (VOC) in sickle cell disease (SCD).Aim To investigate whether Endari could ameliorate intestinal barrier function and improve surv
Externí odkaz:
https://doaj.org/article/2079800808b44270b775cc4fb954444d
Publikováno v:
eJHaem, Vol 4, Iss 4, Pp 1132-1142 (2023)
Abstract Quality of life (QoL) is an important aspect of cancer survivorship. One of the most acute problems that impact survivors in many aspects of activities of daily living and compromise their QoL is the inability to return to employment followi
Externí odkaz:
https://doaj.org/article/86ec617e080946619356ba1a8cb3284c
Publikováno v:
Medicina, Vol 60, Iss 10, p 1581 (2024)
Background and Objectives: In sickle cell disease (SCD), hepatopathy is a cumulative consequence of ischemia/reperfusion (I/R) injury from a vaso-occlusive crisis, tissue inflammation, and iron overload due to blood transfusion. Hepatopathy is a majo
Externí odkaz:
https://doaj.org/article/a59c87cb820a4881a588451b7b22a0b5
Autor:
Elio Haroun, Prashanth Ashok Kumar, Ludovic Saba, Joseph Kassab, Krishna Ghimire, Dibyendu Dutta, Seah H. Lim
Publikováno v:
Journal of Translational Medicine, Vol 21, Iss 1, Pp 1-19 (2023)
Abstract The intestinal barrier is a complex structure that not only regulates the influx of luminal contents into the systemic circulation but is also involved in immune, microbial, and metabolic homeostasis. Evidence implicating disruption in intes
Externí odkaz:
https://doaj.org/article/81e4bea9821445ef9c6a82759fa14439
Autor:
Maroun Bou Zerdan, Prashanth Ashok Kumar, Dulce M. Barrios, Alanna Glidden, Dayana Nasr, Stephanie Niforatos, Ghanshyam Ghelani, Jennifer Leibovitch, Sandy Nasr, Binod KC, Mulham Ombada, Farzam Khokhar, Bhavya Poudyal, Jenish Bhandari, Myera Shahnawaz, Stephen Graziano, Seah H. Lim
Publikováno v:
Frontiers in Oncology, Vol 13 (2023)
BackgroundMany co-existing medical conditions may affect the outcome in patients treated with immune checkpoint inhibitors for advanced cancer. There is currently not any information on whether metabolic syndrome (MetS) impacts the clinical outcome i
Externí odkaz:
https://doaj.org/article/553e90450542467bb054b954b836a303
Publikováno v:
Molecular Therapy: Oncolytics, Vol 23, Iss , Pp 378-386 (2021)
Due to the vague symptomatology of the disease and a lack of effective screening methods, most patients with epithelial ovarian cancer (EOC) present late in their disease. Despite advances in chemotherapeutic agents, the prognosis of these patients h
Externí odkaz:
https://doaj.org/article/1de7433646694abab8d081d7b30f2008
Publikováno v:
Journal of Translational Medicine, Vol 19, Iss 1, Pp 1-11 (2021)
Abstract Painful vaso-occlusive crisis (VOC) remains the most common reason for presenting to the Emergency Department and hospitalization in patients with sickle cell disease (SCD). Although two new agents have been approved by the Food and Drug Adm
Externí odkaz:
https://doaj.org/article/bb03e3ec7b68407f8cc1d543f71e14cf
Autor:
Dibyendu Dutta, Seah H. Lim
Publikováno v:
Biomarker Research, Vol 8, Iss 1, Pp 1-15 (2020)
Abstract Gut microbiota composition influences the balance between human health and disease. Increasing evidence suggests the involvement of microbial factors in regulating cancer development, progression, and therapeutic response. Distinct microbial
Externí odkaz:
https://doaj.org/article/c51ea7da660c4f1ca58782ec5b1b1298
Autor:
Tim Jang, George Mo, Connor Stewart, Leen Khoury, Natalie Ferguson, Ogechukwu Egini, John Muthu, Dibyendu Dutta, Moro Salifu, Seah H Lim
Publikováno v:
Cell Transplantation, Vol 30 (2021)
Hematopoietic stem cell transplant (HSCT) is the only cure for patients with sickle cell disease (SCD). Although most SCD patients experience progressive end-organ damage and shortened lifespans, not all patients follow the same disease course, tempo
Externí odkaz:
https://doaj.org/article/1481e2dfc747401aa9e672bd12abcdda
Publikováno v:
Journal of Translational Medicine, Vol 17, Iss 1, Pp 1-4 (2019)
Abstract Background Due to recurrent hypoxia-reperfusion injury induced by vaso-occlusive crises (VOC), patients with sickle cell disease (SCD) may have intestinal injury and increased permeability. These may explain the qualitative and quantitative
Externí odkaz:
https://doaj.org/article/a233bd1bc1fd4f36b8d73cbe72bf67d4