Zobrazeno 1 - 10
of 67
pro vyhledávání: '"Se-Hyung Park"'
Autor:
Mikala M. Zelows, Corissa Cady, Nikitha Dharanipragada, Anna E. Mead, Zachary A. Kipp, Evelyn A. Bates, Venkateshwari Varadharajan, Rakhee Banerjee, Se-Hyung Park, Nathan R. Shelman, Harrison A. Clarke, Tara R. Hawkinson, Terrymar Medina, Ramon C. Sun, Todd A. Lydic, Terry D. Hinds, Jr., J. Mark Brown, Samir Softic, Gregory A. Graf, Robert N. Helsley
Publikováno v:
Molecular Metabolism, Vol 78, Iss , Pp 101815- (2023)
Background and aims: Genome and epigenome wide association studies identified variants in carnitine palmitoyltransferase 1a (CPT1a) that associate with lipid traits. The goal of this study was to determine the role of liver-specific CPT1a on hepatic
Externí odkaz:
https://doaj.org/article/2e4f326f6761408c9020ccde9aaab299
Autor:
Yipeng Sui, Zhaojie Meng, Se-Hyung Park, Weiwei Lu, Christopher Livelo, Qi Chen, Tong Zhou, Changcheng Zhou
Publikováno v:
Journal of Lipid Research, Vol 61, Iss 5, Pp 696-706 (2020)
The pregnane X receptor (PXR) is a nuclear receptor that can be activated by numerous drugs and xenobiotic chemicals. PXR thereby functions as a xenobiotic sensor to coordinately regulate host responses to xenobiotics by transcriptionally regulating
Externí odkaz:
https://doaj.org/article/e7fbd1d4f3a6416a96b68fab63e33abc
Autor:
Se-Hyung Park, Robert N. Helsley, Leila Noetzli, Ho-Chou Tu, Kristina Wallenius, Gavin O’Mahony, Jeremie Boucher, Jianming Liu, Samir Softic
Publikováno v:
STAR Protocols, Vol 2, Iss 3, Pp 100731- (2021)
Summary: Ketohexokinase (KHK) catalyzes the first step of fructose metabolism. Inhibitors of KHK enzymatic activity are being evaluated in clinical trials for the treatment of non-alcoholic fatty liver disease (NAFLD) and diabetes. Here, we present a
Externí odkaz:
https://doaj.org/article/8ad1dc90a7ee458c9814f80a26cdf195
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 8, Iss 12 (2019)
Background Obesity‐associated chronic inflammation has been known to contribute to atherosclerosis development, but the underlying mechanisms remain elusive. Recent studies have revealed novel functions of IKKβ (inhibitor of NF‐κB [nuclear fact
Externí odkaz:
https://doaj.org/article/67e23002330f4864bd6a88a9597b6a65
Autor:
Robert N. Helsley, Se-Hyung Park, Hemendra J. Vekaria, Patrick G. Sullivan, Lindsey R. Conroy, Ramon C. Sun, María del Mar Romero, Laura Herrero, Joanna Bons, Christina D. King, Jacob Rose, Jesse G. Meyer, Birgit Schilling, C. Ronald Kahn, Samir Softic
Publikováno v:
Journal of Hepatology.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6b34f86448851d5cc8c6409106e18cb3
https://doi.org/10.1016/j.jhep.2023.02.010
https://doi.org/10.1016/j.jhep.2023.02.010
Autor:
Se-Hyung Park, Robert N. Helsley, Taghreed Fadhul, Jennifer L.S. Willoughby, Leila Noetzli, Ho-Chou Tu, Marie H. Solheim, Shiho Fujisaka, Hui Pan, Jonathan M. Dreyfuss, Joanna Bons, Jacob Rose, Christina D. King, Birgit Schilling, Aldons J. Lusis, Calvin Pan, Manoj Gupta, Rohit N. Kulkarni, Kevin Fitzgerald, Philip A. Kern, Senad Divanovic, C. Ronald Kahn, Samir Softic
Publikováno v:
bioRxiv
Non-alcoholic fatty liver disease (NAFLD) is a liver manifestation of metabolic syndrome, and is estimated to affect one billion individuals worldwide. An increased intake of a high-fat diet (HFD) and sugar-sweetened beverages are risk-factors for NA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc902f08dc5e2274cf3e0c9c88090865
https://europepmc.org/articles/PMC9900898/
https://europepmc.org/articles/PMC9900898/
Autor:
Se-Hyung Park, Michelle S M A Damen, Samir Softic, Senad Divanovic, De’Broski R. Herbert, Sara Szabo, Calvin C. Chan, Traci E. Stankiewicz, Jessica R Doll, Robert N. Helsley, Maria E. Moreno-Fernandez
Publikováno v:
International Journal of Obesity (2005)
ObjectiveThe risks of excess sugar intake in addition to high-fat diet consumption on immunopathogenesis of obesity-associated metabolic diseases are poorly defined. Interleukin-4 (IL-4) and IL-13 signaling via IL-4Rα regulates adipose tissue lipoly
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b224bcba79e770fcc5d4a636a95b0bf9
https://doi.org/10.1038/s41366-021-00902-6
https://doi.org/10.1038/s41366-021-00902-6
Autor:
Fang Wang, Jingwei Liu, Rebecca Hernandez, Se-Hyung Park, Ying-Jing Lai, Shuxia Wang, Bruce Blumberg, Changcheng Zhou
Publikováno v:
Drug Metabolism and Disposition. :DMD-AR
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::91f14c8374ce1672895737c3b59cb633
https://doi.org/10.1124/dmd.123.001311
https://doi.org/10.1124/dmd.123.001311
Autor:
Se-Hyung Park, Robert N. Helsley, Taghreed Fadhul, Jennifer L.S. Willoughby, Leila Noetzli, Ho-Chou Tu, Marie H. Solheim, Shiho Fujisaka, Hui Pan, Jonathan M. Dreyfuss, Joanna Bons, Jacob Rose, Christina D. King, Birgit Schilling, Aldons J. Lusis, Calvin Pan, Manoj Gupta, Rohit N. Kulkarni, Kevin Fitzgerald, Philip A. Kern, Senad Divanovic, C. Ronald Kahn, Samir Softic
Publikováno v:
Metabolism. :155591
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::be0ae0a18282774e0fc0b5101516f6fd
https://doi.org/10.1016/j.metabol.2023.155591
https://doi.org/10.1016/j.metabol.2023.155591
Publikováno v:
The Journal of Nutritional Biochemistry. 114:109224
Increased fructose intake from sugar-sweetened beverages and highly processed sweets is a well-recognized risk factor for the development of obesity and its complications. Fructose strongly supports lipogenesis on a normal chow diet by providing both
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1531e963ba3834a85b4328bebbb92aa3
https://doi.org/10.1016/j.jnutbio.2022.109224
https://doi.org/10.1016/j.jnutbio.2022.109224