Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Sébastien Tardy"'
Autor:
Robin Huber, Laurence Marcourt, Fabien Félix, Sébastien Tardy, Emilie Michellod, Leonardo Scapozza, Jean-Luc Wolfender, Katia Gindro, Emerson Ferreira Queiroz
Publikováno v:
Frontiers in Chemistry, Vol 12 (2024)
Phenoxy radical coupling reactions are widely used in nature for the synthesis of complex molecules such as lignin. Their use in the laboratory has great potential for the production of high value compounds from the polyphenol family. While the enzym
Externí odkaz:
https://doaj.org/article/0b8be89b48c04291a4ebcc2873ad4a60
Publikováno v:
CHIMIA, Vol 76, Iss 4 (2022)
Proteolysis Targeting Chimeras (PROTACs) are heterobifunctional molecules that act as degraders. They selectively remove disease-associated proteins by hijacking the Ubiquitin-Proteasome System (UPS). Chemically, they consist of three parts: an E3 li
Externí odkaz:
https://doaj.org/article/43fb9b9592f04683ad43c694b360a691
Autor:
Carlotta Cecchini, Sébastien Tardy, Valentina Ceserani, Jean-Philippe Theurillat, Leonardo Scapozza
Publikováno v:
CHIMIA, Vol 74, Iss 4, Pp 274-277 (2020)
In the context of dysregulated ubiquitylation, the accumulation of oncogenic substrates can lead to tumorigenesis. In particular, mutations in Von Hippel-Lindau (VHL) E3 ubiquitin ligase are related to overexpression of hypoxia-inducible factors (HIF
Externí odkaz:
https://doaj.org/article/0d58a029bbd34270b5cab9e09f786811
Autor:
Luca Mologni, Sébastien Tardy, Alfonso Zambon, Alexandre Orsato, Cédric Schneider, William H. Bisson, Monica Ceccon, Michela Viltadi, David Goyard, Pierre Garcia, Joseph D’Attoma, Sara Pannilunghi, Vito Vece, Jerome Bertho, David Gueyrard, Peter Goekjian, Leonardo Scapozza, Carlo Gambacorti-Passerini
Publikováno v:
ACS Omega, Vol 7, Iss 25, Pp 22059-22060 (2022)
Externí odkaz:
https://doaj.org/article/06412c463a324452867b30b2e8ae1c45
Autor:
Olivier Preynat-Seauve, Evelyne Bao-Vi Nguyen, Yvonne Westermaier, Margaux Héritier, Sébastien Tardy, Yves Cambet, Maxime Feyeux, Aurélie Caillon, Leonardo Scapozza, Karl-Heinz Krause
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2021)
Phenazopyridine is a widely used drug against urinary tract pain. The compound has also been shown to enhance neural differentiation of pluripotent stem cells. However, its mechanism of action is not understood. Based on its chemical structure, we hy
Externí odkaz:
https://doaj.org/article/0b714db4ddf34294a62575c214553ec6
Autor:
Léonie Pellissier, Alexey Koval, Laurence Marcourt, Emerson Ferreira Queiroz, Nicole Lecoultre, Sara Leoni, Luis-Manuel Quiros-Guerrero, Morgane Barthélémy, Bastiaan L. Duivelshof, Davy Guillarme, Sébastien Tardy, Véronique Eparvier, Karl Perron, Jérôme Chave, Didier Stien, Katia Gindro, Vladimir Katanaev, Jean-Luc Wolfender
Publikováno v:
Frontiers in Chemistry, Vol 9 (2021)
The Wnt signaling pathway controls multiple events during embryonic development of multicellular animals and is carcinogenic when aberrantly activated in adults. Breast cancers are dependent on Wnt pathway overactivation mostly through dysregulation
Externí odkaz:
https://doaj.org/article/fee75f1120cc4437a578803c0ea1481a
Publikováno v:
Frontiers in Chemistry, Vol 9 (2021)
Proteolysis Targeting Chimeras (PROTACs) are heterobifunctional degraders that specifically eliminate targeted proteins by hijacking the ubiquitin-proteasome system (UPS). This modality has emerged as an orthogonal approach to the use of small-molecu
Externí odkaz:
https://doaj.org/article/93f3984621bf472994b3e3127e2323b8
Autor:
Luca Mologni, Sébastien Tardy, Alfonso Zambon, Alexandre Orsato, William H. Bisson, Monica Ceccon, Michela Viltadi, Joseph D’Attoma, Sara Pannilunghi, Vito Vece, Jerome Bertho, Peter Goekjian, Leonardo Scapozza, Carlo Gambacorti-Passerini
Publikováno v:
ACS omega. 7(20)
The anaplastic lymphoma kinase (ALK) is abnormally expressed and hyperactivated in a number of tumors and represents an ideal therapeutic target. Despite excellent clinical responses to ALK inhibition, drug resistance still represents an issue and no
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45a7b1e41703657ff1df592093720c15
https://pubmed.ncbi.nlm.nih.gov/35785321
https://pubmed.ncbi.nlm.nih.gov/35785321
Autor:
Luca Mologni, Alexandre Orsato, Alfonso Zambon, Sébastien Tardy, William H. Bisson, Cedric Schneider, Monica Ceccon, Michela Viltadi, Joseph D'Attoma, Sara Pannilunghi, Vito Vece, David Gueyrard, Jerome Bertho, Leonardo Scapozza, Peter Goekjian, Carlo Gambacorti-Passerini
The Anaplastic Lymphoma Kinase (ALK) is a therapeutic target for personalized medicine in selected cancers. Despite excellent clinical responses to ALK inhibitors, most patients develop drug resistance and relapse. New compounds with alternative bind
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf89bd1c05f951a54aeeb8be0996d559
https://hdl.handle.net/11380/1278237
https://hdl.handle.net/11380/1278237
Autor:
Sébastien Tardy, Margaux Héritier, Maxime Feyeux, Yvonne Westermaier, Aurélie Caillon, Evelyne Bao-Vi Nguyen, Leonardo Scapozza, Yves Cambet, Karl-Heinz Krause, Olivier Preynat-Seauve
Publikováno v:
Frontiers in Pharmacology
Frontiers in Pharmacology, Vol 12 (2021)
Frontiers in Pharmacology, Vol 12 (2021)
Phenazopyridine is a widely used drug against urinary tract pain. The compound has also been shown to enhance neural differentiation of pluripotent stem cells. However, its mechanism of action is not understood. Based on its chemical structure, we hy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc8d30b13888ec69bbc94950760ebbd1
http://europepmc.org/articles/PMC8371461
http://europepmc.org/articles/PMC8371461