Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Seónadh O'Leary"'
Autor:
Melissa Bedard, Sanne van der Niet, Elliott M. Bernard, Gregory Babunovic, Tan-Yun Cheng, Beren Aylan, Anita E. Grootemaat, Sahadevan Raman, Laure Botella, Eri Ishikawa, Mary P. O’Sullivan, Seónadh O’Leary, Jacob A. Mayfield, Jeffrey Buter, Adriaan J. Minnaard, Sarah M. Fortune, Leon O. Murphy, Daniel S. Ory, Joseph Keane, Sho Yamasaki, Maximiliano G. Gutierrez, Nicole van der Wel, D. Branch Moody
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 6 (2023)
Induction of lipid-laden foamy macrophages is a cellular hallmark of tuberculosis (TB) disease, which involves the transformation of infected phagolysosomes from a site of killing into a nutrient-rich replicative niche. Here, we show that a terpenyl
Externí odkaz:
https://doaj.org/article/66ad604010504fdab74173379c2c7ca6
Autor:
James Joseph Phelan, Kate McQuaid, Colin Kenny, Karl Michael Gogan, Dónal J. Cox, Sharee Ann Basdeo, Seónadh O’Leary, Simone Christa Tazoll, Cilian Ó Maoldomhnaigh, Mary P. O’Sullivan, Luke A. O’Neill, Maureen J. O’Sullivan, Joseph Keane
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Tuberculosis is the single biggest infectious killer in the world and presents a major global health challenge. Antimicrobial therapy requires many months of multiple drugs and incidences of drug resistant tuberculosis continues to rise. Consequently
Externí odkaz:
https://doaj.org/article/d064450510e04e1fadfdf5fe4ddbe2b6
Autor:
Éilis Dockry, Seónadh O'Leary, Laura E. Gleeson, Judith Lyons, Joseph Keane, Steven G. Gray, Derek G. Doherty
Publikováno v:
OncoImmunology, Vol 7, Iss 6 (2018)
Immunotherapies that target CD1d-restricted invariant NKT (iNKT) cells can prevent tumor growth in murine models but trials in humans have shown limited clinical efficacy. Here, we show that iNKT cells are depleted from blood and bronchial lavage sam
Externí odkaz:
https://doaj.org/article/1b6210d97c56454a9c0b0e1dda0867ba
Autor:
Hugo Charles-Messance, Anna Wedderburn, Emer E. Hackett, Ed C. Lavelle, Mireille Ouimet, Joseph Keane, Natalia Muñoz-Wolf, Laura E. Gleeson, Frederick J. Sheedy, Seónadh O'Leary, Kathryn J. Moore, Daniel G.W. Johnston, Michelle A. Williams, Sinéad C. Corr, Sarah Case, Stephen V. Gordon, Alicia Smyth
Publikováno v:
Cell Reports, Vol 30, Iss 1, Pp 124-136.e4 (2020)
Cell Rep
Cell Rep
Summary: Increased glycolytic metabolism recently emerged as an essential process driving host defense against Mycobacterium tuberculosis (Mtb), but little is known about how this process is regulated during infection. Here, we observe repression of
Autor:
Seónadh O'Leary, Kate McQuaid, Lorraine Thong, Joseph Keane, Stephen V. Gordon, Gina Leisching, Dearbhla M. Murphy, Morgane Mitermite, Cilian Ó Maoldomhnaigh, Karl M. Gogan, Sharee A. Basdeo, Donal J. Cox, James J. Phelan, Amy M. Coleman
Publikováno v:
Frontiers in Immunology
Frontiers in Immunology, Vol 12 (2021)
Frontiers in Immunology, Vol 12 (2021)
In order to mount an appropriate immune response to infection, the macrophage must alter its metabolism by increasing aerobic glycolysis and concomitantly decreasing oxidative phosphorylation; a process known as the Warburg effect. Consequently, lact
Autor:
Seónadh O'Leary, Gemma O'Connor, Joseph Keane, Sally-Ann Cryan, Mary P. O'Sullivan, Ahmad Z Bahlool
Publikováno v:
Journal of Visualized Experiments.
Mycobacterium tuberculosis (Mtb), the causative agent of tuberculosis (TB), was the most significant infectious disease killer globally until the advent of COVID-19. Mtb has evolved to persist in its intracellular environment, evade host defenses, an
Publikováno v:
J Clin Invest
Tuberculosis (TB) is a persistent global pandemic, and standard treatment for it has not changed for 30 years. Mycobacterium tuberculosis (Mtb) has undergone prolonged coevolution with humans, and patients can control Mtb even after extensive infecti
Autor:
Sharee A. Basdeo, Joseph Keane, Mary P. O'Sullivan, Simone Christa Tazoll, Karl M. Gogan, Cilian Ó Maoldomhnaigh, Kate McQuaid, Colin Kenny, Seónadh O'Leary, Donal J. Cox, Luke A. J. O'Neill, Maureen J. O'Sullivan, James J. Phelan
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Tuberculosis is the single biggest infectious killer in the world and presents a major global health challenge. Antimicrobial therapy requires many months of multiple drugs and incidences of drug resistant tuberculosis continues to rise. Consequently
Publikováno v:
Access Microbiology. 2
Mycobacterium tuberculosis (Mtb) is the causative agent for tuberculosis which remains a serious health concern globally. The emergence of multi-drug resistant strains and the failure of BCG vaccine to control the epidemic highlight the need to achie
Autor:
Sally-Ann Cryan, Joseph P. Cassidy, Joseph Keane, Gemma O'Connor, Aidan Fagan-Murphy, Brian D. Robertson, Mary P. O'Sullivan, Seónadh O'Leary, Nitya Krishnan
Ending the tuberculosis (TB) epidemic by 2030 was recently listed in the United Nations (UN) Sustainable Development Goals alongside HIV/AIDS and malaria as it continues to be a major cause of death worldwide. With a significant proportion of TB case
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31ddaab412e64ec20d223a2949363020
http://hdl.handle.net/10044/1/66808
http://hdl.handle.net/10044/1/66808