Zobrazeno 1 - 10
of 85
pro vyhledávání: '"Seán I. O'Donoghue"'
Publikováno v:
Frontiers in Bioinformatics, Vol 3 (2024)
Introduction: When visualizing complex data, the layout method chosen can greatly affect the ability to identify outliers, spot incorrect modeling assumptions, or recognize unexpected patterns. Additionally, visual layout can play a crucial role in c
Externí odkaz:
https://doaj.org/article/ab3a4d2031574962b8ecbc76a1ae2638
Autor:
Marcia A. Munoz, Oliver P. Skinner, Etienne Masle-Farquhar, Julie Jurczyluk, Ya Xiao, Emma K. Fletcher, Esther Kristianto, Mark P. Hodson, Seán I. O’Donoghue, Sandeep Kaur, Robert Brink, David G. Zahra, Elissa K. Deenick, Kristen A. Perry, Avril A.B. Robertson, Sam Mehr, Pravin Hissaria, Catharina M. Mulders-Manders, Anna Simon, Michael J. Rogers
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 19 (2022)
Mevalonate kinase deficiency (MKD) is characterized by recurrent fevers and flares of systemic inflammation, caused by biallelic loss-of-function mutations in MVK. The underlying disease mechanisms and triggers of inflammatory flares are poorly under
Externí odkaz:
https://doaj.org/article/21b5b88799f3482d9c5c720c2d6c2ea8
Autor:
Jenny Vuong, Sandeep Kaur, Julian Heinrich, Bosco K. Ho, Christopher J. Hammang, Benedetta F. Baldi, Seán I. O’Donoghue
Publikováno v:
Visual Informatics, Vol 2, Iss 4, Pp 225-234 (2018)
Novel visualization methods and strategies are necessary to cope with the deluge of datasets present in any scientific field to make discoveries and find answers to previously unanswered questions. These methods and strategies should not only present
Externí odkaz:
https://doaj.org/article/531c3d71169f436087256b26248e0efe
Publikováno v:
BioData Mining, Vol 10, Iss 1, Pp 1-11 (2017)
Abstract Background Recently we surveyed the dark-proteome, i.e., regions of proteins never observed by experimental structure determination and inaccessible to homology modelling. Surprisingly, we found that most of the dark proteome could not be ac
Externí odkaz:
https://doaj.org/article/3812817d3f9947359f0f0b4c59413dee
Autor:
Alberto Santos, Kalliopi Tsafou, Christian Stolte, Sune Pletscher-Frankild, Seán I. O’Donoghue, Lars Juhl Jensen
Publikováno v:
PeerJ, Vol 3, p e1054 (2015)
For tissues to carry out their functions, they rely on the right proteins to be present. Several high-throughput technologies have been used to map out which proteins are expressed in which tissues; however, the data have not previously been systemat
Externí odkaz:
https://doaj.org/article/223cf31830a04e14847fee6eb9cc4e6b
Autor:
James M. Hogan, Daniel Johnson, Seán I. O'Donoghue, Markus Rittenbruch, Margot Brereton, Julian Heinrich, Kellie Vella
Publikováno v:
IEEE Transactions on Visualization and Computer Graphics. 28:4477-4489
Genomic research emerges from collaborative work within and across different scientific disciplines. A diverse range of visualisation techniques has been employed to aid this research, yet relatively little is known as to how these techniques facilit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7f2fb6c16bf9b4a700226659fd3bce9
https://doi.org/10.1109/tvcg.2021.3090746
https://doi.org/10.1109/tvcg.2021.3090746
Autor:
Marcia A. Munoz, Oliver P. Skinner, Etienne Masle-Farquhar, Julie Jurczyluk, Ya Xiao, Emma Fletcher, Esther Kristianto, Mark P. Hodson, Seán I. O’Donoghue, Sandeep Kaur, Robert Brink, David Zahra, Elissa K. Deenick, Kristen Perry, Avril A.B. Robertson, Sam Mehr, Pravin Hissaria, Catharina M. Mulders-Manders, Anna Simon, Michael J. Rogers
SUMMARYMevalonate kinase deficiency (MKD) is caused by biallelic loss-of-function mutations in MVK, leading to recurrent fevers and systemic inflammation. We describe new mouse avatars of MKD bearing p.Val377Ile (the commonest variant) or deletions i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::57df67c4d6564e93318f45df8c27f3bf
https://doi.org/10.1101/2022.02.28.480959
https://doi.org/10.1101/2022.02.28.480959
Autor:
David Thomas, Nicola Bordin, Mark J. Cowley, Seán I. O'Donoghue, Andrea Schafferhans, Mandy L. Ballinger, Sandeep Kaur, Neblina Sikta
MotivationVariant analysis is a core task in bioinformatics that requires integrating data from many sources. This process can be helped by using 3D structures of proteins, which can provide a spatial context that can provide insight into how variant
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3e6ad73d077f566bcccddc5f91c35674
https://doi.org/10.1101/2021.09.10.459756
https://doi.org/10.1101/2021.09.10.459756
SARS‐CoV‐2 structural coverage map reveals viral protein assembly, mimicry, and hijacking mechanisms
Autor:
James B. Procter, Sandeep Kaur, Christian Stolte, Seán I. O'Donoghue, Neblina Sikta, Matt Adcock, Bosco K. Ho, Christian Dallago, Burkhard Rost, Andrea Schafferhans, Stuart Anderson, Nicola Bordin
Publikováno v:
Molecular Systems Biology
Molecular Systems Biology, Vol 17, Iss 9, Pp n/a-n/a (2021)
Molecular Systems Biology, Vol 17, Iss 9, Pp n/a-n/a (2021)
We modeled 3D structures of all SARS‐CoV‐2 proteins, generating 2,060 models that span 69% of the viral proteome and provide details not available elsewhere. We found that ˜6% of the proteome mimicked human proteins, while ˜7% was implicated in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62144547588df9e95af66fa1b9c96d58
http://europepmc.org/articles/PMC8438690
http://europepmc.org/articles/PMC8438690
Autor:
Christopher J. Hammang, Benedetta Frida Baldi, Julian Heinrich, Sandeep Kaur, Seán I. O'Donoghue, Jenny Vuong, Bosco K. Ho
Publikováno v:
Visual Informatics, Vol 2, Iss 4, Pp 225-234 (2018)
Novel visualization methods and strategies are necessary to cope with the deluge of datasets present in any scientific field to make discoveries and find answers to previously unanswered questions. These methods and strategies should not only present
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98992f125efe89a44f0f993fd22b5f48
http://www.sciencedirect.com/science/article/pii/S2468502X18300433
http://www.sciencedirect.com/science/article/pii/S2468502X18300433