A phase I and pharmacological study of topotecan infused over 30 minutes for five days in patients with refractory acute leukemia

Autor: Ek, Rowinsky, Scott Kaufmann, Sd, Baker, Cb, Miller, Se, Sartorius, Mk, Bowling, Tl, Chen, Rc, Donehower, Sd, Gore

Publikováno v: Europe PubMed Central

The principal objectives of this study were to determine the feasibility of escalating doses of the hydrophilic topoisomerase I (topo I) inhibitor topotecan (TPT) as a 30-min infusion daily for 5 days in adults with refractory or relapsed acute leuke

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::572c32de8076061ede5113a2df5e8323
http://europepmc.org/abstract/med/9816150

Absorption, metabolism, and excretion of 14C-temozolomide following oral administration to patients with advanced cancer.

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A phase I and pharmacological study of topotecan infused over 30 minutes for five days in patients with refractory acute leukemia.

Autor: Rowinsky EK; Divisions of Pharmacology and Experimental Therapeutics, Medical Oncology, and Hematological Malignancies, The Johns Hopkins Oncology Center, Baltimore, Maryland 21287, USA., Kaufmann SH, Baker SD, Miller CB, Sartorius SE, Bowling MK, Chen TL, Donehower RC, Gore SD

Publikováno v: Clinical cancer research : an official journal of the American Association for Cancer Research [Clin Cancer Res] 1996 Dec; Vol. 2 (12), pp. 1921-30.

Phase I and pharmacologic study of high doses of the topoisomerase I inhibitor topotecan with granulocyte colony-stimulating factor in patients with solid tumors.

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Publikováno v: Journal of clinical oncology : official journal of the American Society of Clinical Oncology [J Clin Oncol] 1996 Apr; Vol. 14 (4), pp. 1224-35.