Zobrazeno 1 - 10
of 104
pro vyhledávání: '"Scyllatoxin"'
Akademický článek
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Autor:
Vince, Matthew Joseph Kline
Apoptosis is a form of controlled cell death that occurs as a normal part of an organism’s growth and development. Apoptosis is often initiated as a result of external or internal stresses that the cell cannot overcome and thus becomes committed to
Akademický článek
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Molecules that inhibit discrete protein-protein (PPIs) interactions hold immense promise to be developed as therapeutics or chemical genetics agents. The B cell lymphoma 2 (BCL-2) proteins are a family of evolutionarily-related proteins that act as p
Publikováno v:
Journal of Peptide Science. 23:367-373
Anti-apoptotic Bcl-2 proteins are implicated in pathogenic cell survival and have attracted considerable interest as therapeutic targets. We recently developed a class of synthetic peptide based on scyllatoxin (ScTx) designed to mimic the helical BH3
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c3979d067c368dfedb99322129e98b76
https://doi.org/10.1002/psc.2999
https://doi.org/10.1002/psc.2999
Autor:
V. N. Novoseletsky, A.V. Illarionova, S.A. Yakimov, K.S. Kudryashova, E.A. Lyapina, Yu. V. Korolkova, Mikhail P. Kirpichnikov, A. D. Volyntseva, Oksana V. Nekrasova, Konstantin V. Shaitan, Alexey V. Feofanov
Publikováno v:
Journal of Neuroimmune Pharmacology. 12:260-276
Potassium voltage-gated Kv1.6 channel, which is distributed primarily in neurons of central and peripheral nervous systems, is of significant physiological importance. To date, several high-affinity Kv1.6-channel blockers are known, but the lack of s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48abba61c3db5e0e5484924f845aa2fa
https://doi.org/10.1007/s11481-016-9710-9
https://doi.org/10.1007/s11481-016-9710-9
Autor:
Danushka Arachchige, Justin M. Holub
Publikováno v:
The protein journal. 37(5)
The B cell lymphoma 2 (BCL2) proteins are a family of evolutionarily related proteins that act as positive or negative regulators of the intrinsic apoptosis pathway. Overexpression of anti-apoptotic BCL2 proteins in cells is associated with apoptotic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::539b1535f8a951b4caf8cc3ea71e02aa
https://pubmed.ncbi.nlm.nih.gov/30128635
https://pubmed.ncbi.nlm.nih.gov/30128635
Autor:
Toru Kawada, Mikiyasu Shirai, Tsuyoshi Akiyama, Masaru Sugimachi, Shuji Shimizu, Toji Yamazaki
Publikováno v:
Neurochemistry International. 56:263-269
To elucidate the role of Ca 2+ -activated K + (K Ca ) channels in the presynaptic acetylcholine (ACh) release from splanchnic nerve endings and the postsynaptic catecholamine release from chromaffin cells, we applied microdialysis technique to the le
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6f05b9a04f065fc2f5d73884bf5bab5
https://doi.org/10.1016/j.neuint.2009.10.010
https://doi.org/10.1016/j.neuint.2009.10.010
Autor:
Stephan Grissmer, Christian Proepper, Stefan Liebau, Tobias M. Boeckers, Alexander Storch, Bianca Vaida, Paul Dietl, Oliver H. Wittekindt
Publikováno v:
Journal of Neurochemistry. 101:1338-1350
Ion channels are potent modulators for developmental processes in progenitor cells. In a screening approach for different ion channels in neural progenitor cells (NPCs) we observed a 1-ethyl-2-benzimidazolinone (1-EBIO) activated inward current, whic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f07d37737d3f41170e973fa25fe4b25f
https://doi.org/10.1111/j.1471-4159.2006.04437.x
https://doi.org/10.1111/j.1471-4159.2006.04437.x
Publikováno v:
Current Drug Target -CNS & Neurological Disorders. 3:161-167
In most central neurons, small conductance Ca(2+)-activated K(+) channels (SK channels) contribute to afterhyperpolarizations (AHPs), which control neuronal excitability. The medium AHP has pharmacological properties similar to recombinant SK channel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b97d27cb55e8d8b8cb74b8099cf9010
https://doi.org/10.2174/1568007043337472
https://doi.org/10.2174/1568007043337472