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Nuclear PKM2 binds pre-mRNA at folded G-quadruplexes and reveals their gene regulatory role.

Autor: Anastasakis DG; RNA Molecular Biology Laboratory, NIAMS/NIH, Bethesda, MD, USA., Apostolidi M; Department of Cellular and Molecular Physiology, Yale University, New Haven, CT, USA; Systems Biology Institute, Yale University, West Haven, CT, USA., Garman KA; Dermatology Branch, NIAMS/NIH, Bethesda, MD, USA., Polash AH; RNA Molecular Biology Laboratory, NIAMS/NIH, Bethesda, MD, USA., Umar MI; RNA Molecular Biology Laboratory, NIAMS/NIH, Bethesda, MD, USA., Meng Q; Laboratory of Cellular and Molecular Biology, NIDDK/NIH, Bethesda, MD, USA., Scutenaire J; RNA Molecular Biology Laboratory, NIAMS/NIH, Bethesda, MD, USA., Jarvis JE; Dermatology Branch, NIAMS/NIH, Bethesda, MD, USA., Wang X; RNA Molecular Biology Laboratory, NIAMS/NIH, Bethesda, MD, USA., Haase AD; Laboratory of Cellular and Molecular Biology, NIDDK/NIH, Bethesda, MD, USA., Brownell I; Dermatology Branch, NIAMS/NIH, Bethesda, MD, USA., Rinehart J; Department of Cellular and Molecular Physiology, Yale University, New Haven, CT, USA; Systems Biology Institute, Yale University, West Haven, CT, USA. Electronic address: jesse.rinehart@yale.edu., Hafner M; RNA Molecular Biology Laboratory, NIAMS/NIH, Bethesda, MD, USA. Electronic address: markus.hafner@nih.gov.

Publikováno v: Molecular cell [Mol Cell] 2024 Oct 03; Vol. 84 (19), pp. 3775-3789.e6. Date of Electronic Publication: 2024 Aug 16.