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A structure-based designed small molecule depletes hRpn13 ^Pru and a select group of KEN box proteins.

Autor: Lu X; Protein Processing Section, Center for Structural Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, MD, USA., Chandravanshi M; Protein Processing Section, Center for Structural Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, MD, USA., Sabbasani VR; Chemistry and Synthesis Center, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA., Gaikwad S; Laboratory of Cancer Biology and Genetics, National Cancer Institute, Bethesda, MD, USA., Hughitt VK; Laboratory of Cancer Biology and Genetics, National Cancer Institute, Bethesda, MD, USA., Gyabaah-Kessie N; Laboratory of Cancer Biology and Genetics, National Cancer Institute, Bethesda, MD, USA., Scroggins BT; Radiation Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA., Das S; Protein Characterization Laboratory, Cancer Research Technology Program, Frederick National Laboratory for Cancer Research, Leidos Biomedical Research, Inc., Frederick, MD, USA., Myint W; Cancer Innovation Laboratory, Frederick National Laboratory for Cancer Research, Frederick, MD, USA., Clapp ME; Genome Modification Core, Frederick National Laboratory for Cancer Research, Frederick, MD, USA., Schwieters CD; Computational Biomolecular Magnetic Resonance Core, Laboratory of Chemical Physics, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, USA., Dyba MA; Biophysics Resource, Center for Structural Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, MD, USA., Bolhuis DL; Department of Biochemistry and Biophysics and Lineberger Comprehensive Cancer Center, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Koscielniak JW; Basic Science Program, Leidos Biomedical Research Inc., NMR Facility for Biological Research, Center for Structural Biology, National Cancer Institute, National Institutes of Health, Frederick, MD, USA., Andresson T; Protein Characterization Laboratory, Cancer Research Technology Program, Frederick National Laboratory for Cancer Research, Leidos Biomedical Research, Inc., Frederick, MD, USA., Emanuele MJ; Department of Pharmacology and Lineberger Comprehensive Cancer Center, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Brown NG; Department of Pharmacology and Lineberger Comprehensive Cancer Center, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Matsuo H; Cancer Innovation Laboratory, Frederick National Laboratory for Cancer Research, Frederick, MD, USA., Chari R; Genome Modification Core, Frederick National Laboratory for Cancer Research, Frederick, MD, USA., Citrin DE; Radiation Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA., Mock BA; Laboratory of Cancer Biology and Genetics, National Cancer Institute, Bethesda, MD, USA., Swenson RE; Chemistry and Synthesis Center, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA., Walters KJ; Protein Processing Section, Center for Structural Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, MD, USA. kylie.walters@nih.gov.

Publikováno v: Nature communications [Nat Commun] 2024 Mar 20; Vol. 15 (1), pp. 2485. Date of Electronic Publication: 2024 Mar 20.

Hyperpolarized [1- ¹³ C]-Pyruvate Magnetic Resonance Spectroscopic Imaging of Prostate Cancer In Vivo Predicts Efficacy of Targeting the Warburg Effect.

Autor: Scroggins BT; Radiation Oncology Branch, Center for Cancer Research, NCI, NIH, Bethesda, Maryland., Matsuo M; Radiation Biology Branch, Center for Cancer Research, NCI, NIH, Bethesda, Maryland., White AO; Radiation Oncology Branch, Center for Cancer Research, NCI, NIH, Bethesda, Maryland., Saito K; Radiation Biology Branch, Center for Cancer Research, NCI, NIH, Bethesda, Maryland., Munasinghe JP; National Institute of Neurological Disorder and Stroke, NIH, Bethesda, Maryland., Sourbier C; Urologic Oncology Branch, Center for Cancer Research, NIH, Bethesda, Maryland., Yamamoto K; Radiation Biology Branch, Center for Cancer Research, NCI, NIH, Bethesda, Maryland., Diaz V; National Institute of Neurological Disorder and Stroke, NIH, Bethesda, Maryland., Takakusagi Y; Department of Molecular Imaging and Theranostics, National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology, Chiba, Japan., Ichikawa K; Department of Pharmacy, Faculty of Pharmaceutical Sciences, Nagasaki International University, Nagasaki, Japan., Mitchell JB; Radiation Biology Branch, Center for Cancer Research, NCI, NIH, Bethesda, Maryland., Krishna MC; Radiation Biology Branch, Center for Cancer Research, NCI, NIH, Bethesda, Maryland., Citrin DE; Radiation Oncology Branch, Center for Cancer Research, NCI, NIH, Bethesda, Maryland. citrind@mail.nih.gov.

Publikováno v: Clinical cancer research : an official journal of the American Association for Cancer Research [Clin Cancer Res] 2018 Jul 01; Vol. 24 (13), pp. 3137-3148. Date of Electronic Publication: 2018 Mar 29.