Výsledky vyhledávání - "Scrace, Simon"

Dissertation/ Thesis

Novel regulation of SRC family kinase signalling by RASSF1 isoforms

Autor: Scrace, Simon Francis

RASSF1A is a tumour suppressor, the silencing of which occurs through promoter methylation in a variety of human cancers. Loss of RASSF1A is associated with decreased sensitivity to DNA damaging agents and worse prognosis in breast, colon and lung ca

Externí odkaz: http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.581258

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RASSF1C oncogene elicits amoeboid invasion, cancer stemness, and extracellular vesicle release via a SRC/Rho axis:prev. Amoeboid cells are stem-like and induce non-cell autonomous metastasis in vivo

Autor: Vlahov, Nikola, Steenbreek, Sander, Tognoli, Maria Laura, Pankova, Daniela, Eyres, Michael, Cano-Rodriguez, David, Scrace, Simon, von Kriegsheim, Alexander, Rots, Marianne, van Rheenen, Jacco, O'Neill, Eric

Publikováno v: Vlahov, N, Steenbreek, S, Tognoli, M L, Pankova, D, Eyres, M, Cano-Rodriguez, D, Scrace, S, von Kriegsheim, A, Rots, M, van Rheenen, J & O'Neill, E 2022, ' RASSF1C oncogene elicits amoeboid invasion, cancer stemness, and extracellular vesicle release via a SRC/Rho axis : prev. Amoeboid cells are stem-like and induce non-cell autonomous metastasis in vivo ', EMBO Journal . https://doi.org/10.15252/embj.2021107680

Activation of the GTPase RhoA increases actinomyosin contractility and a population of highly invasive amoeboid-like cells in tumours. Here we identified that the pro-metastatic oncogene RASSF1C is an activator of RhoA/ROCK signaling and amoeboid mot

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______3094::3f2773c9502572f104261d38b667a18a
https://hdl.handle.net/20.500.11820/349ea53c-7090-46b5-a6e8-139f325b25e9

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