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ALKBH5 is a 2-oxoglutarate (2OG) and ferrous iron-dependent nucleic acid oxygenase (NAOX) that catalyzes the demethylation of N(6)-methyladenine in RNA. ALKBH5 is upregulated under hypoxia and plays a role in spermatogenesis. We describe a crystal st
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::ee8354804cfca00fd3bda39268c0200b
https://doi.org/10.1093/nar/gku085
https://doi.org/10.1093/nar/gku085
Autor:
Gerber JS; Division of Nephrology, University Hospital Zurich, Zurich, Switzerland.; Division of Nephrology, Ente Ospedaliero Cantonale, Lugano, Switzerland., Arroyo EMP; Institute of Physiology, University of Zurich, Winterthurerstrasse 190, CH-8057, Zurich, Switzerland., Pastor J; Charles and Jane Pak Center for Mineral Metabolism and Clinical Research, University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA., Correia M; Division of Nephrology and Hypertension, University of Bern and University Hospital Bern, Bern, Switzerland., Rudloff S; Division of Nephrology and Hypertension, University of Bern and University Hospital Bern, Bern, Switzerland., Moe OW; Charles and Jane Pak Center for Mineral Metabolism and Clinical Research, University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA.; Department of Internal Medicine, Division of Nephrology, University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA.; Department of Physiology, University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA., Egli-Spichtig D; Institute of Physiology, University of Zurich, Winterthurerstrasse 190, CH-8057, Zurich, Switzerland.; National Center of Competence in Research, NCCR Kidney.CH, Zurich, Switzerland., Mohebbi N; Division of Nephrology, University Hospital Zurich, Zurich, Switzerland.; National Center of Competence in Research, NCCR Kidney.CH, Zurich, Switzerland., Wagner CA; Institute of Physiology, University of Zurich, Winterthurerstrasse 190, CH-8057, Zurich, Switzerland. Carsten.Wagner@physiol.uzh.ch.; National Center of Competence in Research, NCCR Kidney.CH, Zurich, Switzerland. Carsten.Wagner@physiol.uzh.ch.
Publikováno v:
Pflugers Archiv : European journal of physiology [Pflugers Arch] 2024 Nov 27. Date of Electronic Publication: 2024 Nov 27.
Autor:
Gerber JS; Division of Nephrology, Ente Ospedaliero Cantonale, Lugano, Switzerland.; Faculty of Biomedical Science, Università della Svizzera Italiana, Lugano, Switzerland., De Marchi S; Division of Nephrology, Ente Ospedaliero Cantonale, Lugano, Switzerland., Gaspert A; Department of Pathology and Molecular Pathology, University Hospital Zürich, Zürich, Switzerland., Fehr T; Department of Internal Medicine, Cantonal Hospital Graubünden, Chur, Switzerland.; University of Zürich (UZH), Zürich, Switzerland., Cippà PE; Division of Nephrology, Ente Ospedaliero Cantonale, Lugano, Switzerland.; Faculty of Biomedical Science, Università della Svizzera Italiana, Lugano, Switzerland.
Publikováno v:
Case reports in nephrology and dialysis [Case Rep Nephrol Dial] 2024 Aug 29; Vol. 14 (1), pp. 148-157. Date of Electronic Publication: 2024 Aug 29 (Print Publication: 2024).
Autor:
Choi H; Chemistry Research Laboratory, Department of Chemistry, University of Oxford, 12, Mansfield Road, Oxford, OX1 3TA, UK.; Department of Bioscience and Biotechnology, Sejong University, 209 Neungdong-ro, Kwangjin-gu, Seoul, 05006, Korea., Hardy AP; Chemistry Research Laboratory, Department of Chemistry, University of Oxford, 12, Mansfield Road, Oxford, OX1 3TA, UK., Leissing TM; Chemistry Research Laboratory, Department of Chemistry, University of Oxford, 12, Mansfield Road, Oxford, OX1 3TA, UK., Chowdhury R; Chemistry Research Laboratory, Department of Chemistry, University of Oxford, 12, Mansfield Road, Oxford, OX1 3TA, UK., Nakashima Y; Chemistry Research Laboratory, Department of Chemistry, University of Oxford, 12, Mansfield Road, Oxford, OX1 3TA, UK., Ge W; Chemistry Research Laboratory, Department of Chemistry, University of Oxford, 12, Mansfield Road, Oxford, OX1 3TA, UK., Markoulides M; Chemistry Research Laboratory, Department of Chemistry, University of Oxford, 12, Mansfield Road, Oxford, OX1 3TA, UK., Scotti JS; Chemistry Research Laboratory, Department of Chemistry, University of Oxford, 12, Mansfield Road, Oxford, OX1 3TA, UK., Gerken PA; Chemistry Research Laboratory, Department of Chemistry, University of Oxford, 12, Mansfield Road, Oxford, OX1 3TA, UK., Thorbjornsrud H; Chemistry Research Laboratory, Department of Chemistry, University of Oxford, 12, Mansfield Road, Oxford, OX1 3TA, UK., Kang D; Center for Catalytic Hydrocarbon Functionalizations, Institute for Basic Science (IBS), Daejeon, 34141, Korea.; Department of Chemistry, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, 34141, Korea., Hong S; Center for Catalytic Hydrocarbon Functionalizations, Institute for Basic Science (IBS), Daejeon, 34141, Korea.; Department of Chemistry, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, 34141, Korea., Lee J; Department of Chemical and Biological Engineering, Northwestern University, 2145 Sheridan Road, Evanston, IL, 60208, USA., McDonough MA; Chemistry Research Laboratory, Department of Chemistry, University of Oxford, 12, Mansfield Road, Oxford, OX1 3TA, UK., Park H; Department of Bioscience and Biotechnology, Sejong University, 209 Neungdong-ro, Kwangjin-gu, Seoul, 05006, Korea. hspark@sejong.ac.kr., Schofield CJ; Chemistry Research Laboratory, Department of Chemistry, University of Oxford, 12, Mansfield Road, Oxford, OX1 3TA, UK. christopher.schofield@chem.ox.ac.uk.
Publikováno v:
Communications chemistry [Commun Chem] 2020 May 01; Vol. 3 (1), pp. 52. Date of Electronic Publication: 2020 May 01.
Autor:
Gerber JS; Division of Nephrology, University Hospital Zurich, Switzerland Jennifer.ScottiGerber@eoc.ch.; Division of Nephrology and Dialysis, Ospedale Regionale di Lugano, Switzerland., Berney-Meyer L; Division of Nephrology, University Hospital Zurich, Switzerland., Segerer S; Division of Nephrology, University Hospital Zurich, Switzerland.; Division of Nephrology, Dialysis and Transplantation, Kantonsspital Aarau, Switzerland.
Publikováno v:
Peritoneal dialysis international : journal of the International Society for Peritoneal Dialysis [Perit Dial Int] 2018 May-Jun; Vol. 38 (3), pp. 231-232.
Autor:
Dickinson RS; MRC/University of Edinburgh Centre for Inflammation Research, The Queen's Medical Research Institute, University of Edinburgh, Edinburgh, EH16 4TJ, UK., Murphy F; MRC/University of Edinburgh Centre for Inflammation Research, The Queen's Medical Research Institute, University of Edinburgh, Edinburgh, EH16 4TJ, UK., Doherty C; MRC/University of Edinburgh Centre for Inflammation Research, The Queen's Medical Research Institute, University of Edinburgh, Edinburgh, EH16 4TJ, UK., Williams S; MRC/University of Edinburgh Centre for Inflammation Research, The Queen's Medical Research Institute, University of Edinburgh, Edinburgh, EH16 4TJ, UK., Mirchandani A; MRC/University of Edinburgh Centre for Inflammation Research, The Queen's Medical Research Institute, University of Edinburgh, Edinburgh, EH16 4TJ, UK., Willson J; MRC/University of Edinburgh Centre for Inflammation Research, The Queen's Medical Research Institute, University of Edinburgh, Edinburgh, EH16 4TJ, UK., Scotti JS; Chemistry Research Laboratory, Department of Chemistry, University of Oxford, Oxford, OX1 3TA, UK., Preston G; Department of Plant Sciences, University of Oxford, Oxford, OX1 3RB, UK., Schofield CJ; Chemistry Research Laboratory, Department of Chemistry, University of Oxford, Oxford, OX1 3TA, UK., Whyte MKB; MRC/University of Edinburgh Centre for Inflammation Research, The Queen's Medical Research Institute, University of Edinburgh, Edinburgh, EH16 4TJ, UK., Walmsley SR; MRC/University of Edinburgh Centre for Inflammation Research, The Queen's Medical Research Institute, University of Edinburgh, Edinburgh, EH16 4TJ, UK.
Publikováno v:
Wellcome open research [Wellcome Open Res] 2017 Oct 26; Vol. 2, pp. 104. Date of Electronic Publication: 2017 Oct 26 (Print Publication: 2017).
Autor:
Horita S; Chemistry Research Laboratory, Department of Chemistry, University of Oxford, 12 Mansfield Road, Oxford OX1 3TA, UK; Department of Physiology, Anatomy and Genetics, University of Oxford, Parks Road, Oxford OX1 3PT, UK., Scotti JS; Chemistry Research Laboratory, Department of Chemistry, University of Oxford, 12 Mansfield Road, Oxford OX1 3TA, UK., Thinnes C; Chemistry Research Laboratory, Department of Chemistry, University of Oxford, 12 Mansfield Road, Oxford OX1 3TA, UK., Mottaghi-Taromsari YS; Chemistry Research Laboratory, Department of Chemistry, University of Oxford, 12 Mansfield Road, Oxford OX1 3TA, UK., Thalhammer A; Chemistry Research Laboratory, Department of Chemistry, University of Oxford, 12 Mansfield Road, Oxford OX1 3TA, UK., Ge W; Chemistry Research Laboratory, Department of Chemistry, University of Oxford, 12 Mansfield Road, Oxford OX1 3TA, UK., Aik W; Chemistry Research Laboratory, Department of Chemistry, University of Oxford, 12 Mansfield Road, Oxford OX1 3TA, UK., Loenarz C; Chemistry Research Laboratory, Department of Chemistry, University of Oxford, 12 Mansfield Road, Oxford OX1 3TA, UK., Schofield CJ; Chemistry Research Laboratory, Department of Chemistry, University of Oxford, 12 Mansfield Road, Oxford OX1 3TA, UK. Electronic address: christopher.schofield@chem.ox.ac.uk., McDonough MA; Chemistry Research Laboratory, Department of Chemistry, University of Oxford, 12 Mansfield Road, Oxford OX1 3TA, UK. Electronic address: michael.mcdonough@chem.ox.ac.uk.
Publikováno v:
Structure (London, England : 1993) [Structure] 2015 Apr 07; Vol. 23 (4), pp. 639-52. Date of Electronic Publication: 2015 Feb 26.
Autor:
Scotti JS; Chemistry Research Laboratory, Department of Chemistry, University of Oxford, Oxford OX1 3TA, United Kingdom;, Leung IK; Chemistry Research Laboratory, Department of Chemistry, University of Oxford, Oxford OX1 3TA, United Kingdom;, Ge W; Chemistry Research Laboratory, Department of Chemistry, University of Oxford, Oxford OX1 3TA, United Kingdom; Chinese Academy of Medical Sciences, Beijing 100005, China;, Bentley MA; Department of Plant Sciences, University of Oxford, Oxford OX1 3RB, United Kingdom;, Paps J; Department of Zoology, University of Oxford, Oxford OX1 3PS, United Kingdom;, Kramer HB; Department of Physiology, Anatomy, and Genetics, University of Oxford, Oxford OX1 3QX, United Kingdom; and., Lee J; Chemistry Research Laboratory, Department of Chemistry, University of Oxford, Oxford OX1 3TA, United Kingdom;, Aik W; Chemistry Research Laboratory, Department of Chemistry, University of Oxford, Oxford OX1 3TA, United Kingdom;, Choi H; Chemistry Research Laboratory, Department of Chemistry, University of Oxford, Oxford OX1 3TA, United Kingdom;, Paulsen SM; Department of Plant Sciences, University of Oxford, Oxford OX1 3RB, United Kingdom;, Bowman LA; Department of Pathology, University of Oxford, Oxford OX1 3RE, United Kingdom., Loik ND; Chemistry Research Laboratory, Department of Chemistry, University of Oxford, Oxford OX1 3TA, United Kingdom;, Horita S; Chemistry Research Laboratory, Department of Chemistry, University of Oxford, Oxford OX1 3TA, United Kingdom; Department of Physiology, Anatomy, and Genetics, University of Oxford, Oxford OX1 3QX, United Kingdom; and., Ho CH; Chemistry Research Laboratory, Department of Chemistry, University of Oxford, Oxford OX1 3TA, United Kingdom;, Kershaw NJ; Chemistry Research Laboratory, Department of Chemistry, University of Oxford, Oxford OX1 3TA, United Kingdom;, Tang CM; Department of Pathology, University of Oxford, Oxford OX1 3RE, United Kingdom., Claridge TD; Chemistry Research Laboratory, Department of Chemistry, University of Oxford, Oxford OX1 3TA, United Kingdom;, Preston GM; Department of Plant Sciences, University of Oxford, Oxford OX1 3RB, United Kingdom;, McDonough MA; Chemistry Research Laboratory, Department of Chemistry, University of Oxford, Oxford OX1 3TA, United Kingdom;, Schofield CJ; Chemistry Research Laboratory, Department of Chemistry, University of Oxford, Oxford OX1 3TA, United Kingdom; christopher.schofield@chem.ox.ac.uk.
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2014 Sep 16; Vol. 111 (37), pp. 13331-6. Date of Electronic Publication: 2014 Sep 02.
Autor:
Aik W; Department of Chemistry, Chemistry Research Laboratory, University of Oxford, 12 Mansfield Road, Oxford, OX1 3TA, UK., Scotti JS, Choi H, Gong L, Demetriades M, Schofield CJ, McDonough MA
Publikováno v:
Nucleic acids research [Nucleic Acids Res] 2014 Apr; Vol. 42 (7), pp. 4741-54. Date of Electronic Publication: 2014 Jan 30.