Zobrazeno 1 - 10
of 39
pro vyhledávání: '"Scott. A. Lujan"'
Autor:
Jessica S. Williams, Scott. A. Lujan, Mercedes E. Arana, Adam B. Burkholder, Percy P. Tumbale, R. Scott Williams, Thomas A. Kunkel
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-12 (2024)
Abstract Finalization of eukaryotic nuclear DNA replication relies on DNA ligase 1 (LIG1) to seal DNA nicks generated during Okazaki Fragment Maturation (OFM). Using a mutational reporter in Saccharomyces cerevisiae, we previously showed that mutatio
Externí odkaz:
https://doaj.org/article/b31b217e5a9e48d9b498d08517dfc52e
Autor:
Scott A. Lujan, Matthew J. Longley, Margaret H. Humble, Christopher A. Lavender, Adam Burkholder, Emma L. Blakely, Charlotte L. Alston, Grainne S. Gorman, Doug M. Turnbull, Robert McFarland, Robert W. Taylor, Thomas A. Kunkel, William C. Copeland
Publikováno v:
Genome Biology, Vol 21, Iss 1, Pp 1-34 (2020)
Abstract Background Acquired human mitochondrial genome (mtDNA) deletions are symptoms and drivers of focal mitochondrial respiratory deficiency, a pathological hallmark of aging and late-onset mitochondrial disease. Results To decipher connections b
Externí odkaz:
https://doaj.org/article/15e2915608854379b2a6c820537c4ae2
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-10 (2019)
DNA polymerases epsilon and delta, respectively, perform the majority of leading and lagging strand replication of the eukaryotic nuclear genome. Here the authors map the ribonucleotide fingerprints of the polymerases to show the special roles of pol
Externí odkaz:
https://doaj.org/article/7b4b72b62f4042e1ae134de4b46a5866
Autor:
Adam B. Burkholder, Scott A. Lujan, Christopher A. Lavender, Sara A. Grimm, Thomas A. Kunkel, David C. Fargo
Publikováno v:
BMC Genomics, Vol 19, Iss 1, Pp 1-19 (2018)
Abstract Background Identification of mutations from next-generation sequencing data typically requires a balance between sensitivity and accuracy. This is particularly true of DNA insertions and deletions (indels), that can impart significant phenot
Externí odkaz:
https://doaj.org/article/b4ed54e91cb7433e914d1cbea74bcdfe
Autor:
Marta A. Garbacz, Scott A. Lujan, Adam B. Burkholder, Phillip B. Cox, Qiuqin Wu, Zhi-Xiong Zhou, James E. Haber, Thomas A. Kunkel
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
DNA polymerases δ and ε (Pols δ and ε) are thought to be responsible for lagging and leading strand synthesis, respectively. Here the authors present evidence that Pol δ contributes to the initiation of leading strand replication in budding yeas
Externí odkaz:
https://doaj.org/article/0ec48e9ef60b4225a524868988d1cef0
Publikováno v:
Cells, Vol 10, Iss 5, p 1224 (2021)
We describe the contribution of DNA mismatch repair (MMR) to the stability of the eukaryotic nuclear genome as determined by whole-genome sequencing. To date, wild-type nuclear genome mutation rates are known for over 40 eukaryotic species, while mea
Externí odkaz:
https://doaj.org/article/07126a2a4c6b412181bf58d5d0406685
Publikováno v:
Methods in Molecular Biology ISBN: 9781071629215
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d83083380d6a5cbeed141408b5015b31
https://doi.org/10.1007/978-1-0716-2922-2_28
https://doi.org/10.1007/978-1-0716-2922-2_28
Autor:
Zhi-Xiong Zhou, Scott A. Lujan, Adam B. Burkholder, Jordan St. Charles, Joseph Dahl, Corinne E. Farrell, Jessica S. Williams, Thomas A. Kunkel
Publikováno v:
Nat Struct Mol Biol
Accurate DNA replication of an undamaged template depends on polymerase selectivity for matched nucleotides, exonucleolytic proofreading of mismatches, and removal of remaining mismatches via DNA mismatch repair (MMR). DNA polymerases (Pols) δ and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea76473e3447cf0de6d060d9e2bcc527
https://doi.org/10.1038/s41594-021-00691-6
https://doi.org/10.1038/s41594-021-00691-6
Autor:
Elena I. Stepchenkova, Piotr A. Mieczkowski, Thomas A. Kunkel, Adam B. Burkholder, Thomas D. Petes, Denis A. Kiktev, Peter M. J. Burgers, Margaret Dominska, Joseph Dahl, Scott A. Lujan, Tony Zhang
Publikováno v:
Nucleic Acids Research
Iron-sulfur clusters (4Fe–4S) exist in many enzymes concerned with DNA replication and repair. The contribution of these clusters to enzymatic activity is not fully understood. We identified the MET18 (MMS19) gene of Saccharomyces cerevisiae as a s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e8d3cda85e55d05e987d2244cf4b037
http://europepmc.org/articles/PMC8191807
http://europepmc.org/articles/PMC8191807
Publikováno v:
Crit Rev Biochem Mol Biol
Ribonucleotides are the most abundant non-canonical nucleotides in the genome. Their vast presence and influence over genome biology is becoming increasingly appreciated. Here we review the recent progress made in understanding their genomic presence
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54484f61baaec847580d46115aee964e
https://doi.org/10.1080/10409238.2020.1869175
https://doi.org/10.1080/10409238.2020.1869175