Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Scott Yeudall"'
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
Heme degradation by the heme oxygenase (HMOX) family of enzymes is critical for maintaining homeostasis and limiting heme-induced tissue damage. Macrophages express HMOX1 and 2 and are critical sites of heme degradation in healthy and diseased states
Externí odkaz:
https://doaj.org/article/87d8bc2ff8f8423cbc165739e69ff514
Autor:
Brittany A Martínez, Rosalie G Hoyle, Scott Yeudall, Mitchell E Granade, Thurl E Harris, J David Castle, Norbert Leitinger, Michelle L Bland
Publikováno v:
PLoS Genetics, Vol 16, Iss 11, p e1009192 (2020)
During infection, cellular resources are allocated toward the metabolically-demanding processes of synthesizing and secreting effector proteins that neutralize and kill invading pathogens. In Drosophila, these effectors are antimicrobial peptides (AM
Externí odkaz:
https://doaj.org/article/68fbace5dc1f44709095beda0b986904
Autor:
Scott Yeudall, Clint M. Upchurch, Philip V. Seegren, Caitlin M. Pavelec, Jan Greulich, Michael C. Lemke, Thurl E. Harris, Bimal N. Desai, Kyle L. Hoehn, Norbert Leitinger
Publikováno v:
Science Advances. 8
Acetyl-CoA carboxylase (ACC) regulates lipid synthesis; however, its role in inflammatory regulation in macrophages remains unclear. We generated mice that are deficient in both ACC isoforms in myeloid cells. ACC deficiency altered the lipidomic, tra
Publikováno v:
Circulation Research. 131
Pannexin 1 (Panx1), a ubiquitously expressed ATP release membrane channel, has been shown to play a role in inflammation and blood pressure regulation. Panx1 channel function is inhibited by spironolactone, a frontline therapy for heart failure patie
Autor:
Clint M. Upchurch, Scott Yeudall, Caitlin M. Pavelec, Dennis Merk, Jan Greulich, Mohan Manjegowda, Shyam S. Raghavan, Irina M. Bochkis, Michael M. Scott, Edward Perez-Reyes, Norbert Leitinger
Publikováno v:
Science advances. 8(28)
Oxidized phosphatidylcholines (OxPCs) are implicated in chronic tissue damage. Hyperlipidemic LDL-R-–deficient mice transgenic for an OxPC-recognizing IgM fragment (scFv-E06) are protected against nonalcoholic fatty liver disease (NAFLD). To examin
Autor:
Clint M. Upchurch, Scott Yeudall, Caitlin M. Pavelec, Mohan Manjegowda, Irina M. Bochkis, Michael Scott, Edward Perez‐Reyes, Norbert Leitinger
Publikováno v:
The FASEB Journal. 36
Publikováno v:
The FASEB Journal. 36
Publikováno v:
Am J Transplant
The role of extracellular purine nucleotides, including adenosine triphosphate (ATP) and adenosine, as modulators of post-transplantation outcome and ischemia-reperfusion injury is becoming increasingly evident. Upon pathological release of ATP, bind
Autor:
Clint Upchurch, Scott Yeudall, Caitlin Pavelec, Dennis Merk, Jan Greulich, Mohan Manjegowda, Shyam Raghavan, Irina Bochkis, Michael Scott, Edward Perez-Reyes, Norbert Leitinger
Publikováno v:
Free Radical Biology and Medicine. 192:93
Autor:
Alex Shimozono, Matt Mahoney, Scott Yeudall, Elizabeth Jaekle, Micah Newton, Rene P.F. Kanters, James A. Sikorski, Kristen Elofson, Evan Crawford, Evan Clark, John T. Gupton, Veronica Moore-Stoll, Will Curry, Wen Juekun, Annie Lane
Publikováno v:
Tetrahedron. 74:7408-7420
Pyrroles and quinolones represent core structures, which are routinely found in both natural and synthetic bioactive substances. Consequently, the development of efficient and regiospecific methods for the preparation of such heterocycles with unique